TY - JOUR AU - Hafid, Achmad Fuad AU - Febrianty, Niniet AU - Septiani, Ria Putri AU - Ranggaditya, Dimas AU - Fabriana, Lintang Hudha AU - Widyawaruyanti, Aty PY - 2016/01/01 Y2 - 2024/03/28 TI - ANTIMALARIAL ACTIVITY OF CRUDE EXTRACTS OF ARTOCARPUS HETEROPHYLLUS, ARTOCARPUS ALTILIS, AND ARTOCARPUS CAMANSI JF - Asian Journal of Pharmaceutical and Clinical Research JA - Asian J Pharm Clin Res VL - 9 IS - 1 SE - Original Article(s) DO - UR - https://journals.innovareacademics.in/index.php/ajpcr/article/view/9248 SP - 279-281 AB - <p>Objective: This research investigated in vitro and in vivo antimalarial activity of leaves and stem bark crude extract of Artocarpus species, focusing on<br />Artocarpus heterophyllus, Artocarpus altilis, and Artocarpus camansi against Plasmodium falciparum and Plasmodium berghei.<br />Methods: Leaves and stem bark extracts of three Artocarpus species were tested for their antimalarial activities. The antimalarial in vitro test was<br />conducted using P. falciparum (3D7 strain) culture in RPMI-1640 medium, while the antimalarial in vivo test was performed based on Peter's test (The<br />4 days suppressive test) that using P. berghei (strain ANKA) infected mice.<br />Results: From total 6 extracts of Artocarpus leaves and stembark, 2 extracts showed good antimalarial activities against P. falciparum and P. berghei.<br />A. heterophyllus leaves extract (AHL) and A. altilis leaves extract (AAL) were classified as good to moderately active against P. falciparum with inhibition<br />concentration (IC<br />) value of 9.35 µg/ml and 1.32 µg/ml, respectively. In vivo antimalarial activity showed that AHL and AAL were very active against<br />P. berghei with effective dose (ED<br />50<br />50<br />) value of 8.33 mg/kg body weight and 0.82 mg/kg body weight, respectively.<br />Conclusion: AAL has shown as the most active antimalarial activity with IC<br />50<br /> value of 1.32 µg/ml and ED<br /> value of 0.82 mg/kg body weight. AAL may<br />become a potential candidate of the antimalarial drug from Artocarpus species.<br />Keywords: Artocarpus heterophyllus, Artocarpus altilis, Artocarpus camansi, Antimalarial activity.<br />50</p> ER -