NANOTECHNOLOGY-BASED COSMECEUTICALS: A REVIEW
Nanotechnology signifies the evolving area of research and development, concerned in delivering innovative solutions to increase the efficacy of a product. In recent times, application of nanotechnology is rising in the arena of cosmeceuticals and seems to be promising in overcoming certain drawbacks associated with the traditional products. The nanotechnology-based delivery techniques have proved to offer advantages of greater stability, higher efficacy and have also been reported to show prolonged effects. Nanoparticles are also proficient in modifying the flux, targeting the drug to the location, tailoring the size of drug and in making the stratum corneum permeable in a selective manner. The rapid evolution of nanotechnology has given rise to great aspirations; however there are certain concerns still, regarding the possible hazards of nanoparticles to the human health, which could be neglected because of their less significant toxicity. This review gives a brief overview of the various novel nano-carriers for cosmeceuticals like nanoemulsions, liposomes, solid lipid nanoparticles(SLNs), dendrimers, inorganic nanoparticles, nanocrystals, etc. Safety of nanoparticles use and also the different routes of exposure to the nanoparticles have been discussed here.
Keywords: Cosmeceutical, Nanotechnology, Stratum corneum, Nano-carrier, Hazard.
2. U.S. Food and Drug Administration. Is it a cosmetic, a drug, or both? (Or is it soap?). Available from: http://www.fda.gov/cosmetics/guidancecomplianceregulatoryinformation/ucm074201.htm. [Last accessed on 01 Aug 2015].
3. Fulekar MH. Nanotechnology: importance and application. India: IK International Publishing House; 2010.
4. Mukta S, Adam F. Cosmeceuticals in day-to-day clinical practice. J Drugs Dermatol 2010;9:s62â€“6.
5. Brandt FS, Cazzaniga A, Hann M. Cosmeceuticals: current trends and market analysis. Semin Cutaneous Med Surg 2011;30:141â€“3.
6. Mu L, Sprando RL. Application of nanotechnology in cosmetics. Pharm Res 2010;27:1746â€“9.
7. Padamwar MN, Pokharkar VB. Development of vitamin loaded topical liposomal formulation using factorial design approach: drug deposition and stability. Int J Pharm 2006;320:37â€“44.
8. Buzea C, Blandino IIP, Robbie K. Nanomaterials and nanoparticles: sources and toxicity. Biointerphases 2007;4:MR171â€“72.
9. BBC Research. Nanostructured materials for the biomedical. Pharmaceutical, and Cosmetic Markets; 2007.
10. Papakostas D, Rancan F, Sterry W, Blume-Peytavi U, Vogt A. Nanoparticles in dermatology. Arch Dermatol Res 2011;303:533-50.
11. Patidar A, Thakur DS, Kumar P, Verma J. A review on novel lipid-based nanocarriers. Int J Pharm Pharm Sci 2010;2:30-5.
12. Maali, Hamed, Mosavian MT. Preparation and application of nanoemulsions in the last decade (2000â€“2010). J Dispersion Sci Technol 2013;34:92-105.
13. Van den Bergh BAI, Vroom J, Gerritsen H, Junginger HE, Bouwstra JA. Interactions of elastic and rigid vesicles with human skin in vitro: Electron microscopy and two-photon excitation microscopy. Biochim Biophys Acta 1999;1461:155â€“73.
14. Yamazaki K, Tanaka M. Development of a new w/o emulsion-type nail-enamel. Congress Preprints 1990;1:464-95.
15. Patravale VB, Mandawgade SD. Novel cosmetic delivery systems: an application update. Int J Cosmet Sci 2008;30:19â€“33.
16. Kaur IP, Agrawal R. Nanotechnology: a new paradigm in cosmeceuticals. Recent Pat Drug Delivery Formulation 2007;1:171â€“82.
17. Muller-Goymann CC. Physicochemical characterization of colloidal drug delivery systems such as reverse micelles, vesicles, liquid crystals and nanoparticles for topical administration. Eur J Pharm Biopharm 2004;58:343â€“56.
18. Aparajita V. Liposomes as carriers in skin ageing. Int J Curr Pharm Res 2014;6:1-7.
19. Lasic DD. Novel applications of liposomes. Trends Biotechnol 1998;16:307â€“21.
20. Kazi KM. Niosome: a future of targeted drug delivery systems. J Adv Pharm Technol Res 2010;1:374â€“80.
21. Sankhyan A, Pawar P. Recent trends in noisome as vesicular drug delivery system. J Appl Pharm Sci 2012;2:20â€“32.
22. Lâ€™OrÃ©al. Cosmetic and Pharmaceutical Compositions Containing Niosomes and a Water-Soluble polyamide, And a Process for Preparing These Compositions; 1989.
23. Poletto FS, Beck RCR, Guterres SS, Pohlmann AR. Polymeric nanocapsule: concepts and applications. In: Beck R, Guterres S, Pohlmann A. editors. Nanocosmetics and Nanomedicines: New Approaches for Skin Care. Germany: Springer; 2011. p. 47â€“51.
24. Kothamasu P, Kanumur H, Ravur N. Nanocapsules: the weapons for novel drug delivery systems. BioImpacts 2012;2:71â€“81.
25. Puri D, Bhandari A, Sharma P, Choudhary D. Lipid nanoparticles (SLN, NLC): a novel approach for cosmetic and dermal pharmaceutical. J Global Pharma Technol 2010;2:1-15.
26. Ekambaram P, Sathali AAH, Priyanka H. Solid lipid nanoparticles: a review. Sci Rev Chem Commun 2012;2:80â€“102.
27. PardeikeJ, Hommoss A, Muller RH. Lipid nanoparticles (SLN, NLC) in cosmetic and pharmaceutical dermal products. Int J Pharm 2009;366:170â€“84.
28. Wissing SA, Mader K, Muller RH. Solid lipid nanoparticles (SLN) as a novel carrier system offering the prolonged release of the perfume Allure (Chanel). Proc Int Symp Controlled Release Bioact Mater 2000;27:311â€“2.
29. Muller RH, Petersen RD, Hommoss A, Pardeike J. Nanostructured lipid carriers (NLC) in cosmetic dermal products. Adv Drug Delivery Rev 2007;59:522â€“30.
30. Mei Z, Wu Q, Hu S, Li X, Yang X. Triptolide loaded solid lipid nanoparticle-hydrogel for topical application. Drug Dev Ind Pharm 2005;31:161â€“8.
31. Souto EB, Muller RH. Cosmetic features and applications of lipid nanoparticles (SLN, NLC). Int J Cosmet Sci 2008;30:157â€“65.
32. Muller RH, Mader K, Gohla S. Lipid nanoparticles (SLN, NLC) in cosmetic and pharmaceutical dermal products. Int J Pharm 2009;366:170â€“84.
33. Keck CM, Muller RH. Drug nanocrystals of poorly soluble drugs produced by high-pressure homogenization. Eur J Pharm Biopharm 2006;62:3â€“16.
34. Sakamoto J, Annapragada A, Decuzzi P, Ferrari M. Antibiological barrier nano vector technology for cancer applications. Expert Opin Drug Delivery 2007;4:359â€“69.
35. Petersen. Nanocrystals for use in topical cosmetic formulations and method of production thereof. US Patent US 20100047297A1; 2010.
36. Petersen R. Nanocrystals for use in topical cosmetic formulations and method of production thereof. Abbott GmbH and Co. US Patent 60/866233; 2008.
37. Bansal S, Bansal M, Kumria R. Nanocrystals: current strategies and trends. Int J Res Pharm Biomed Sci 2012;3:406-19.
38. Drug-Dev Newsletter. Dendrimers and dendrons: facets of pharmaceutical nanotechnology. Available from: http://www.kellerfoundation.com/ME2/dirmod.asp?sid=4306B1E9C3CC4E07A4D64E23FBDB232C&nm=Back+Issues&type=Publishing&mod=Publications%3A%3AArticle&mid=8F3A7027421841978F18BE895F87F791&tier=4&id=9B9BA1DAA5BE455A85A81D97382FE885. [Last accessed on 05 Aug 2015]
39. Furukawa H, Limura T. Copolymer having carbosiloxanedendrimer structure, and composition and cosmetic containing the same. U. S. Patent 20120263662A1; 2012.
40. Svenson S, Tomalia DA. Dendrimers in biomedical applications-reflections on the field. Adv Drug Delivery Rev 2005;57:2106â€“29.
41. Tournihac F, Simon P. Cosmetic or dermatological topical compositions comprising dendritic polyesters. U. S. Patent 6,287,552; 2001.
42. Lin Y, Yan L. Broad spectrum anti-bactericidal ointmentnano. CN Patent. CN 1480045 A; 2004.
43. Haveli SD, Walter P. Hair fibre as a nanoreactor in controlled synthesis of fluorescent gold nanoparticles. Nano Lett 2012;12:6212â€“7.
44. Hyde S, Andersson A, Larsson K. The Language of Shape. 1sted. New York: Elsevier; 1997.
45. Kimmes SC, Feltin C. Cosmetic composition comprising an oil and a polymer both bearing a hydrogen-bond-generating joining group, and cosmetic treatment process. Eur Patent 2575751A1; 2013.
46. Albrecht H, Schreiber J. Hair care products with dispersed liquid crystals exhibiting the cubic phases. W. O. Patent 2002041850A1; 2002.
47. Ribier A, Biatry B. Cosmetic or dermatologic oil/water dispersion stabilized with cubic gel particles and method of preparation. Eur Patent 0711540B1; 2000.
48. Simonnet JT, Sonneville O, Legret S. Nanoemulsion based on phosphoric acid fatty acid esters and its uses in the cosmetics, dermatological, pharmaceutical, and/or ophthalmological fields. U. S. Patent 6274150 B1; 2001.
49. Kroto HW, Heath JR, Oâ€™Brien SC, Curl RF, Smalley RE. C60: Buckminsterfullerene. Nature 1985;318:162â€“3.
50. Lens M. Use of fullerenes in cosmetics. Recent Pat Biotechnol 2009;3:118â€“23.
51. Cusan C, Da Ros T, Spalluto S. A new multi-charged C60 derivative: synthesis and biological properties. Eur J Org Chem 2002;17:2928â€“34.
52. Inui S, Aoshima H, Nishiyama A, Itami S. Improvement of acne vulgaris by topical fullerene application: unique impact on skin care. Nanomedicine 2011;7:238â€“41.
53. Biagini G, Zizzi A, Giantomassi F. Cutaneous absorption of nanostructured chitin associated with natural synergistic molecules (lutein). J Appl Cosmetol 2008;26:69â€“80.
54. Morganti P, Fabrizi G, Bruno C. Protective effects of oral antioxidantson skin and eye function. Skinmed 2004;3:310â€“6.
55. Morganti P, Fabrizi G, Palombo P. Chitin-nanofibrils: a new active cosmetic carrier. J Appl Cosmetol 2008;26:105â€“20.
56. Morganti P, Fabrizi G, Ruocco E. Chitin nanofibrils improved photo protection. Cosmet Toiletries 2009;124:66â€“73.
57. Fabrizi G, Morganti P, Morganti G. A new sun to rejuvenate the skin. J Appl Cosmetol 2008;26:159â€“66.
58. Biagini G, Zizzi A, Tucci G. Chitin nanofibrils linked to chitosan glycolate as spray, gel and gauze preparations for wound repair. J Bioact Compat Polym 2007;22:525â€“38.
59. Mezzana P. Clinical efficacy of a new chitin-nanofibrils based gel in wound healing. Acta Chirurgiae Plasticae 2008;50:81â€“4.
60. Popov AP, Lademann J, Priezzhev AV, Myllyla R. Effect of size of TiO2 nanoparticles embedded into stratum corneum on ultraviolet-A and ultraviolet-B sun-blocking properties of the skin. J Biomed Optics 2005;10:1â€“9.
61. Cross SE, Innes B, Roberts MS, Tsuzuki T, Robertson TA, McCormick P. Human skin penetration of sunscreen nanoparticles: In vitro assessment of a novel micronized zinc oxide formulation. Skin Pharmacol Physiol 2007;20:148-54.
62. Dransfield GP. Inorganic sunscreens. Radiat Prot Dosimetry 2000;91:271â€“3.
63. Murphy GM. Sunblocks: mechanisms of action. Photodermatol Photoimmunol Photomed 1999;15:34â€“6.
64. Clarence S. The toxicity of gold nanoparticles in relation to their physiochemical properties. Biomed Res 2013;24:400-13.
65. Service RF. Nanomaterials show signs of toxicity. Science 2003;300:243.
66. Kelly KL. Nanotechnology grows up. Science 2004;304:1732-4.
67. Zhao YL, Xing GM, Chai ZF. Nanotoxicology: are carbon nanotubes safe? Nat Nanotechnol 2008;3:191-2.
68. Brumfiel GA. A little knowledge. Nature 2003;424:246-8.
69. The Royal Society and the Royal Academy of Engineering, UK. Nanoscience and nanotechnologies. Section 8.3.3, paragraphs 24, 23, and 25; 2004.
70. Oberdorster G, Oberdorster E, Oberdorster J. Nanotoxicology: an emerging discipline evolving from studies of ultrafine particles. Environ Health Perspect 2005;113:823â€“39.
71. Yah CS, Simate G, Iyuke SE. Nanoparticles toxicity and their routes of exposures. Pak J Pharm Sci 2012;25:477â€“91.
72. Kreyling WG, Semmler-Behnke M, Moller W. Ultrafine particle-lung interactions: does size matter? J Aerosol Med 2006;19:74-83.
73. Zhu MT, Feng WY, Wang Y, Wang B, Wang M, Ouyang H, et al. Particokinetics and extrapulmonary translocation of intratracheally instilled ferric oxide nanoparticles in rats and the potential health risk assessment. Toxicol Sci 2009;107:342-51.
74. Wang B, Feng WY, Wang M, Wang TC, Gu YQ, Zhu MT. Acute toxicological impact of nano-and submicro-scaled zinc oxide powder on healthy adult mice. J Nanopart Res 2008;10:263-76.
75. Paul JAB, Roel PFS. Toxicological characterization of engineered nanoparticles. In: Gupta RB, Kompella UB. editors. Nanoparticle technology for Drug Delivery. New York: Taylor and Francis; 2006. p. 161â€“70.
76. Raj S, Jose U, Sumod S, Sabitha M. Nanotechnology in cosmetics: opportunities and challenges. J Pharm BioAllied Sci 2012;4:186â€“93.
77. Buzea C, Pacheco II, Robble K. Nanomaterial and nanoparticles: sources and toxicity. Biointerphases 2007;2:MR17-71.
78. Cevc G, Vierl U. Nanotechnology and the transdermal route. A state of the art review and critical appraisal. J Controlled Release 2010;141:277â€“99.
79. Toll R, Jacobi U, Richter H, Lademann J, Schaefer H, Blume-Peytavi U. Penetration profile of microspheres in follicular targeting of terminal hair follicles. J Invest Dermatol 2004;123:168â€“76.
80. Gulson B, Mccall M, Korsch M. Small amounts of zinc from zinc oxide particles in sunscreens applied outdoors is absorbed through human skin. Toxicol Sci 2010;118:140â€“9.
81. Gulson B, Mccall M, Korsch M, Gomez L. Dermal absorption of ZnO particles from sunscreens applied to humans at the beach. In: International Conference on Nanoscience and Nanotechnology, Sydney; 2010.