PREPARATION OF FERROUS SULFATE MICROCAPSULES AS A SUSTAINED RELEASE DOSAGE FORMS
Objective: The main purpose of this study was to optimize the different methods for the preparation for the preparation sustained release microencapsulated ferrous sulfate as a solid dosage form.Methods: Ferrous sulfate was prepared as microcapsules using three microencapsulation methods. Complex coacervation, aqueous colloidal polymer dispersions, and solvent removal methods were used to prepare various formulas with different coating agents (acacia, gelatin, sodium alginate and ethylcellulose). The formation and texture characteristics, entrapment efficiency, release profiles, particle size and storage stability of ferrous microcapsules were evaluated in this study.Results: The encapsulation efficiency and hardening varied considerably among these three preparation methods. Encapsulation of ferrous sulfate by complex coacervation with a coating agent (gelatin and acacia) showed problems in hardening and poor encapsulation efficiency. However, ferrous sulfate when coated by sodium alginate at 1:1 (coat: core) ratio using aqueous colloidal polymer dispersion method showed acceptable encapsulation efficiency (67%Â±0.1). Moreover, ferrous sulfate/sodium alginate microcapsules hardened successively when dropping into CaCl2 solution (2% w/v). A same hardening features and values of encapsulation efficiency (68 %Â±0. 6) Were obtained by solvent removal methods. Especially, after tween 80 and carboxyl methyl cellulose were added to the aqueous phase in the process of coating with ethylcellulose. However, sustained release microcapsules were produced by aqueous colloidal polymer dispersion method. The sustained-release sodium alginate/ferrous sulfate was stable for 30 d in both refrigeration and room temperature.
Conclusion: The aqueous polymer dispersion gave sustain release microcapsules which were uniform, hard and stable during storage at both room temperature and refrigeration.
Keywords: Ferrous sulfate, Microcapsules, Complex coacervation, Aqueous colloidal, Polymer dispersion, Solvent removal
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