• Sumit Durgapal Department of Pharmaceutical Sciences, Bhimtal Campus, Kumaun University Nainital, Uttrakhand India
  • Sayantan Mukhopadhyay Department of Pharmaceutical Sciences, SGRRITS, Patel Nagar, Dehradun, Uttrakhand, India
  • Laxmi Goswami Government Polytechnic Mallital, Nainital Uttrakhand India



Floating Microparticles, Ciprofloxacin, Ethylcellulose and HPMC


Objective: The main purpose of this study is to prepare a floating micro articulated drug delivery system of ciprofloxacin by using non-aqueous solvent evaporation technique to increase the bioavailability and therapeutic effectiveness of the drug by prolonging its gastric residence time.

Methods: Floating microparticles were prepared by using different low-density polymers such as ethyl cellulose and hydroxypropyl methylcellulose either alone or in combination with the aid of non-aqueous solvent evaporation technique. All the formulated microparticles were subjected to various evaluation parameters such as percentage yield, drug content, drug entrapment, rheological studies, floating characteristics and in vitro drug release studies.

Results: Drug-excipient compatibility studies performed with the help of FTIR instrument indicated that there were no interactions. Results revealed that non-aqueous solvent evaporation technique is a suitable technique for the preparation of floating microspheres as most of the formulations were discrete and spherical in shape with a good yield of 65% to 85% and 15 to 22 h of floating duration with 90% of maximum percentage floating capacity shown by formulation FM9. Though, different drug-polymer ratios, as well as a combination of polymers, play a significant role in the variation of overall characteristics of formulations. Based on the data of various evaluation parameters such as particle size analysis, drug content, drug entrapment, rheological studies and in vitro drug release characteristics formulation FM9 was found to fulfil the criteria of ideal floating drug delivery system.

Conclusion: Floating microparticles were successfully prepared, and from this study, it can be concluded that the developed floating microspheres of ciprofloxacin can be used for prolonged drug release in the stomach to improve the bioavailability and patient compliance.


Download data is not yet available.


Klausner EA, Lavy E, Friedman M, Hoffman A. Expandable gastro-retentive dosage forms. J Controlled Release 2003;90:143-62.

Gutierrez-Rocca J, Omidian H, Shah K. Progresses in gastro retentive drug delivery systems. PharmaTech; 2003. p. 152-6.

Desai KG, Park HJ. Study of gamma-irradiation effects on chitosan microparticles. Drug Delivery 2006;13:39-50.

Patel A, Ray S, Thakur RS. In vitro evaluation and optimisation of controlled release floating drug delivery system of metformin hydrochloride. Daru 2006;14:57-64.

Shabaraya AR, Narayanacharyulu R. Design and evaluation of chitosan microspheres of metoprolol tartrate for sustained release. Indian J Pharm Sci 2003;65:250-2.

Jain SK, Agrawal GP, Jain NK. Evaluation of porous carrier-based is floating orlistat microspheres for gastric delivery. AAPS Pharm Sci Tech 2006;7:E1-E9.

Rahman Z, Ali M, Khar RK. Design and evaluation of bilayer floating tablets of captopril. Acta Pharm 2006;56:49-57.

Levis SR, Deasy P. Pharmaceutical applications of size reduced grades of surfactant co-processed microcrystalline cellulose. Int J Pharm 2001;230:25-33.

Chowdary KPR, Rao YS. Mucoadhesive microcapsules of glipizide: characterization, in vitro and in vivo evaluation. Indian J Pharm Sci 2003;65:279-84.

Sinko PJ, Singh Y, Martin AN. Micromeritics Martin’s physical pharmacy and pharmaceutical sciences: physical chemical and biopharmaceutical principles in the pharmaceutical sciences. Philadelphia: Lippincott Williams Wilkins 2006;6:442-68.

Kulkarni GT, Gowthamarajan K, Suresh B. Stability testing of pharmaceutical products: an overview. Indian J Pharm Educ 2004;38:194-202.

Shovarani KN, Goundalkar AG. Preparation and evaluation of microsphere of diclofenac sodium. Indian J Pharm Sci 1994;56:45-50.

Bhumkar DR, Maheshwari M, Patil VB, Pokharkar VB. Studies on the effect of variabilities by response surface methodology for naproxane microspheres. Indian Drugs 2003;40:455-61.

Velivela S, Abbulu K, Vinyas M, Pati NB. Formulation and in vitro evaluation of ritonavir floating tablets by melt granulation technique. Int J Appl Pharm 2016;8:12-5.

Sakhare SS, Yadav AV, Jadhav PD. Design, development and characterization of mucoadhesive gastro spheres of carvedilol. Int J Appl Pharm 2016;8:37-42.

Peppas NA. Analysis of fickian and non-fickian drug release from polymers. Pharm Acta Helv 1985;60:110–1.



How to Cite

Durgapal, S., Mukhopadhyay, S., & Goswami, L. (2016). PREPARATION, CHARACTERIZATION AND EVALUATION OF FLOATING MICROPARTICLES OF CIPROFLOXACIN. International Journal of Applied Pharmaceutics, 9(1), 1–8.



Original Article(s)

Most read articles by the same author(s)