FORMULATION AND EVALUATION OF POLYHERBAL FLOATING EFFERVESCENCE TABLET CONTAINING PEDALIUM MUREX AND TRIBULUS TERRESTRIS FRUIT EXTRACTS


Chitra Devi Venkatachalam, Mothil Sengottian, Tamizharasi Sengodan

Abstract


Objective: The present investigation was based on the design and evaluation of floating tablets of Pedalium murex and Tribulus terrestris fruit extracts as the medicinal source and the excipients that can enhance the bioactivity and prolong the gastric retention time.

Methods: The fruit extracts were prepared from the powdered dry fruits of Pedalium murex and Tribulus terrestris using Soxhelt apparatus for 8 h. Direct compression technique was used for the formulation of polyherbal floating effervescence tablets which consists of different compositions of Hydroxy Propyl Methyl Cellulose (HPMC K4M, HPMC K15M), Micro Crystalline Cellulose (MCC) and Sodium bicarbonate (NaHCO3). The formulations were evaluated for thickness, hardness, friability, average weight variation, drug content, floating lag time, duration of floating and in vitro drug release. The data obtained from the in vitro dissolution studies were fitted in different models.

Results: All the tablets were satisfactory during the preformulation studies while F11 polyherbal formulation showed the maximum floating time of 15 h, minimum floatation lag time of 35 s and drug release of 100.12%. The dissolution kinetic studies for the optimum formulation was found to follow Korsemeyer and Peppas model with R2 value, rate constant KK and n as 0.9819, 1.0492 and 1.7385 respectively with a significance of P<0.05 and showed better results compared to that of film coated herbal tablets.

Conclusion: Thus this polyherbal floating effervescence tablets can be used not only as an effective drug release method for herbal drugs to enhance their bioactivity but also as a replacement for film coated herbal tablets.


Keywords


Pedalium murex, Tribulus terrestris, Gastric retention time, Polyherbal floating effervescence tablet, Hydroxypropyl methyl cellulose

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About this article

Title

FORMULATION AND EVALUATION OF POLYHERBAL FLOATING EFFERVESCENCE TABLET CONTAINING PEDALIUM MUREX AND TRIBULUS TERRESTRIS FRUIT EXTRACTS

Keywords

Pedalium murex, Tribulus terrestris, Gastric retention time, Polyherbal floating effervescence tablet, Hydroxypropyl methyl cellulose

DOI

10.22159/ijap.2017v9i2.16319

Date

01-03-2017

Additional Links

Manuscript Submission

Journal

International Journal of Applied Pharmaceutics
Vol 9, Issue 2, 2017 Page: 10-15

Online ISSN

0975-7058

Statistics

239 Views | 48 Downloads

Authors & Affiliations

Chitra Devi Venkatachalam
Department of Chemical Engineering, Kongu Engineering College, Erode, Tamil Nadu, India

Mothil Sengottian
Department of Chemical Engineering, Kongu Engineering College, Erode, Tamil Nadu, India

Tamizharasi Sengodan
Department of Pharmaceutics, Nandha College of Pharmacy, Erode, Tamil Nadu, India


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