EFFECT OF WATER CONTENT IN KNEADING METHOD OF SOLID DISPERSION TECHNIQUE FOR SOLUBILITY ENHANCEMENT


Shankarguru P., Ramya Devi D., Vedha Hari Bn

Abstract


Objective: The main objective of the research work was to optimize the water requirement/content used in kneading method for solid dispersion/inclusion complex formation between water insoluble drug and polymer.

Methods: Nimesulide (model drug) and β-cyclodextrin were taken in a different ratio such as 1:1, 1:3 and 1:5 and, the mixture was triturated well for half hour. Water was incorporated to the mixture in different levels like 75%, 50%, 25% w/v in divided proportions and 0% (no water addition, but the mixture was triturated continuously). After each part of water addition, the mixture was triturated well for 10 min and dried using hot air over for 30 min at 50 °C and sieved using sieve no: 44. The complexes formed were subjected for various analytical characterization studies including solubility, particle size, the angle of repose, tapped density, Carr’s index, fourier transform infrared spectrometry (FTIR), thermo gravimetric-differential thermal analysis (TG-TDA), x-ray diffraction (XRD) studies and in vitro dissolution studies.

Results: The dissolution studies showed improvement in the release of nimesulide, which depended on the percentage level of water. The solubility of the sample was increased with increasing the concentration of the inclusion complex formed. Kneading method was proved to be a successful technique for formation of stable inclusion complex of nimesulide with β-cyclodextrin. All the formulations exhibited acceptable particle size and solubility in the range of 22.6±2 to 29±5 and 45±5 to 133±3.5 respectively.

Conclusion: Nimesulide and β-cyclodextrin complex was successfully prepared and characterized for the drug-polymer stability and interactions. The result confirmed that the liquid content in the solid dispersion prepared by the kneading method played an important role in the dissolution of the poorly soluble drug. 


Keywords


Nimesulide, β-cyclodextrin, Solid dispersion, Kneading method

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About this article

Title

EFFECT OF WATER CONTENT IN KNEADING METHOD OF SOLID DISPERSION TECHNIQUE FOR SOLUBILITY ENHANCEMENT

Keywords

Nimesulide, β-cyclodextrin, Solid dispersion, Kneading method

DOI

10.22159/ijap.2017v9i5.17765

Date

15-09-2017

Additional Links

Manuscript Submission

Journal

International Journal of Applied Pharmaceutics
Vol 9, Issue 5 (Aug-Sep), 2017 Page: 14-21

Online ISSN

0975-7058

Statistics

47 Views | 28 Downloads

Authors & Affiliations

Shankarguru P.
Department of Pharmaceutical Technology, School of chemical and Biotechnology, SASTRA University, Thanjavur 613401, Tamil Nadu, India
India

Ramya Devi D.
Department of Pharmaceutical Technology, School of chemical and Biotechnology, SASTRA University, Thanjavur 613401, Tamil Nadu, India

Vedha Hari Bn
Department of Pharmaceutical Technology, School of chemical and Biotechnology, SASTRA University, Thanjavur 613401, Tamil Nadu, India


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