FORMULATION OF FAST-DISSOLVING TABLETS OF DOXAZOSIN MESYLATE DRUG BY DIRECT COMPRESSION METHOD


G. B. Preethi, Sayan Banerjee, H. N. Shivakumar, M Ravi Kumar

Abstract


Objective: The rationale of the current research work was to formulate and evaluate fast-dissolving tablets of doxazosin mesylate with minimum disintegration time and improved dissolution efficiency using solid dispersion method.

Methods: Solid dispersions of doxazosin mesylate and polyethylene glycol 8000 in different ratios were prepared using the kneading method. The prepared solid dispersions were subjected to drug interaction and dissolution studies to select the effective solid dispersion for the formulation of fast-dissolving tablets. Fast dissolving tablets containing drug-polyethylene glycol 8000 solid dispersion (1:3) were prepared using various super-disintegrants such as crospovidone, croscarmellose sodium, mixture and coprocessed crospovidone and croscarmellose sodium in concentration range of 2% and 5% by direct compression technique. The prepared formulations (F1–F16) were evaluated for post compression parameters; hardness, thickness, friability, wetting time, disintegration time, and in–vitro drug release.

Results: Drug doxazosin mesylate showed enhanced aqueous solubility of 13.3µg/ml in the presence of polyethylene glycol 8000. Differential scanning calorimetery and Fourier transform infrared spectroscopy studies confirmed no interaction between drug and polyethylene glycol 8000and, drug-polyethylene glycol 8000 solid dispersion showed cumulative drug release of 44.48% in 60 min. Formulated FDT of drug-polyethylene glycol 8000 solid dispersion, containing coprocessed mixture of crospovidone and croscarmellose sodium (5%) exhibited disintegration time of 14.5s with percentage cumulative release of 92.46% in 60 min.

Conclusion: The work reasonably concludes that for the formulated doxazosin mesylate-fast dissolving tablets, disintegration time was effectively reduced by the presence of coprocessed mixture of crospovidone and croscarmellose sodium and dissolution efficiency was improved by preparation of solid dispersion with polyethylene glycol 8000.


Keywords


Coprocessed superdisintegrants, Doxazosin mesylate, Fast-dissolving tablets, Crospovidone, Croscarmellose sodium

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About this article

Title

FORMULATION OF FAST-DISSOLVING TABLETS OF DOXAZOSIN MESYLATE DRUG BY DIRECT COMPRESSION METHOD

Keywords

Coprocessed superdisintegrants, Doxazosin mesylate, Fast-dissolving tablets, Crospovidone, Croscarmellose sodium

DOI

10.22159/ijap.2017v9i5.18168

Date

15-09-2017

Additional Links

Manuscript Submission

Journal

International Journal of Applied Pharmaceutics
Vol 9, Issue 5 (Aug-Sep), 2017 Page: 22-28

Online ISSN

0975-7058

Statistics

69 Views | 36 Downloads

Authors & Affiliations

G. B. Preethi
Department of Pharmaceutics, KLEU College of Pharmacy, Bangalore
India

Sayan Banerjee
Department of Pharmaceutics, KLEU College of Pharmacy, Bangalore
India

H. N. Shivakumar
Department of Pharmaceutics, KLEU College of Pharmacy, Bangalore
India

M Ravi Kumar
Geethanjali College of Pharmacy, Cheeryal (V), Keesara(M), RR District, Telangana State 521132
India


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