OPTIMISATION OF IBUPROFEN FAST DISSOLVING TABLETS EMPLOYING STARCH XANTHATE USING 23 FACTORIAL DESIGN


R. Santosh Kumar, T. Naga Satya Yagnesh, V. Goutham Kumar

Abstract


Objective: To evaluate starch xanthate as a super disintegrant in the formulation of fast dissolving tablets of poorly soluble drugs employing 23 factorial design.

Methods: Starch xanthate was synthesized by gelatinization process. The synthesized starch xanthate was subjected to physical and micromeritic evaluation. To establish as starch xanthate as a super disintegrant, fast dissolving tablet of ibuprofen was prepared employing starch xanthate in different proportions in each case by direct compression method employing 23 factorial design. All fast dissolving tablets prepared were evaluated for drug content, hardness, friability, disintegration time and other dissolution characteristics like percent dissolved in 5 min (PD5), Dissolution efficiency in 5 Min (DE5%) and first order rate constant(K1).

Results: The starch xanthate prepared was found to be fine, free flowing slightly crystalline powder. Starch xanthate exhibited good swelling in water. Fourier transform infrared spectra (FTIR) and Differential scanning calorimetry (DSC) study indicated the absence of interaction between Ibuprofen and starch xanthate. All the fast dissolving tablets formulated employing starch xanthate were of good quality with regard to drug content(100±5%), hardness (3.6–4 kg/sq. cm), and friability (0.12-0.15%). The disintegration time of all the formulated tablets was found to be in the range of 13±0. 02 to 108±0.02s. The optimised formulation FL7 has the least disintegration time i.e., 13±0. 02s. The In vitro wetting time of the formulated tablets was found to be in the range of 90±0.15 to 369±0.17s. The In–Vitro wetting time was less (i.e., 90s) in optimized formulation FL7. The water absorption ratio of the formulated tablets was found to be in the range of 94±0.16 to 192±0.15%. The cumulative drug dissolved in the optimized formulation FL7 was found to be 99.63±0.24% in 5 min.

Conclusion: Starch xanthate was found to be a super disintegrant which enhanced the dissolution efficiency when combined with sodium starch glycolate, croscarmellose sodium, with the ibuprofen and hence it could be used in the formulation of fast dissolving tablets to provide immediate release of the contained drug within 5 min.


Keywords


Fast dissolving, Superdisintegrant, Starch xanthate, Dissolution efficiency.

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References


Amrita Soni, Vaibhav Rajoriya, Varsha Kashaw. Formulation development and evaluation of fast dissolving tablet of ramipril. Int J Pharm Pharm Sci 2015;7:127-31.

Paramita Dey, Arnabi Ghosh. Wafers: an innovative advancement of orodispersible films. Int J Appl Pharm 2016;8:1-7.

Abdelbary G, Prinderre P, Couani C, Taochim J, Reynier JP, Riccerelle P. The preparation of orally disintegrating tablets using a hydrophilic waxy binder. Int J Pharm 2004;278:423-33.

Anupam Roy. Orodispersible tablets: a review. Asian J Pharma Clin Res 2016;9:19-26.

Ashish Masih, Amar Kumar, Shivam Singh, Ajay Kumar Tiwari. Fast dissolving tablets: a review. Int J Cur Pharm Res 2017;9:8-18.

Biradar S, Bhagavati S, Kuppasad I. Fast dissolving drug delivery system: a brief overview. Int J Pharmacol 2005;4:2, 233-5.

Indurwade NH, Rajyaguru TH, Nakhat PD. Noval approach-fast dissolving tablets. Ind Drug 2002;38:405-9.

The United States Pharmacopoeia 29, National Formulary 24, Asian Edition. Rockville, MD: USPC, Inc; 2006. p. 1890.

Jacob S, Shirwaikar A, Joseph A, Srinivasan KK. Novel co-processed excipient of mannitol and microcrystalline callous for preparing fast dissolving tablet of Glipizide. Ind J Pharm Sci 2007:69:633-9.

Hiremath JG, Shastry CS, Srinath MS. Pharmaceutical approaches of taste masking in oral dorage forms. Ind Drug 2004;41:253-7.

Abdelbary A, Elshafeey AH, Zidan G. Comparative effects of different cellulosic-based directly compressed orodispersible tablets on oral bioavailability of famotidine. Car Poly 2009;77:799-806.

Battu SK, Michael AR, Soumyajit M, Madhusudan Y. Formulation and evaluation of rapidly disintegrating fenoverine tablets: effect of super disintegrants. Drug Dev Ind Pharm 2007;33:1225-32.

Goel H, Vora N, Rana V. A novel approach to optimize and formulate fast disintegrating tablets for nausea and vomiting. AAPS PharmSciTech 2008;9:774–8.

Satheesh Jogala, Laxman Ankathi, Ramesh Naik Jarupula. Glimepiride fast disintegrating tablets: formulation, evaluation and in vivo disintegration and dynamic studies. Int J Pharm Pharm Sci 2016;8:271-8.

Indian Pharmacopoeia 2010. p. 218-20.

V Sai Kishore, D Gowtham Kumar, B Sudheer, M Sandeep. Design and development of fast dissolving tablets of ibuprofen. Res Rev Pharm Pharm Sci 2013;2:65-71.




About this article

Title

OPTIMISATION OF IBUPROFEN FAST DISSOLVING TABLETS EMPLOYING STARCH XANTHATE USING 23 FACTORIAL DESIGN

Keywords

Fast dissolving, Superdisintegrant, Starch xanthate, Dissolution efficiency.

DOI

10.22159/ijap.2017v9i5.19707

Date

15-09-2017

Additional Links

Manuscript Submission

Journal

International Journal of Applied Pharmaceutics
Vol 9, Issue 5 (Aug-Sep), 2017 Page: 51-59

Online ISSN

0975-7058

Statistics

72 Views | 78 Downloads

Authors & Affiliations

R. Santosh Kumar
GITAM Institute of Pharmacy, GITAM University, Rushikonda, Visakhapatnam, A.P 530045, India
India

T. Naga Satya Yagnesh
GITAM Institute of Pharmacy, GITAM University, Rushikonda, Visakhapatnam, A.P 530045, India
India

V. Goutham Kumar
GITAM Institute of Pharmacy, GITAM University, Rushikonda, Visakhapatnam, A.P 530045, India
India


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