DEVELOPMENT AND EVALUATION OF TIOCONAZOLE LOADED EMULGEL


Shailendra Kumar Sah, Ashutosh Badola, Sayantan Mukhopadhyay

Abstract


Objective: The objective of the present work was to develop, characterize and evaluate the tioconazole loaded emulgel and to prove that emulgel can be the best alternative for delivery of hydrophobic drug topically.

Methods: for the preparation of stable Emulgel, firstly gels were prepared using different polymers as carbopol 934 and xanthan gum, followed by preparation of emulsions and finally mixed together (table 1). Emulgel was evaluated for physical appearance, pH, spreadability, extrudability, viscosity, swelling index, dilution test, centrifuge test, drug content, in vitro release study, kinetic analysis of release data, antifungal activity and stability study for 3 mo. A comparative study was also performed between prepared emulgels with available marketed antifungal cream.

Results: All evaluation parameters were in acceptable range with good physical appearance and the pH in the range of 5.5 to 6.8. The results show that the extrudability was in the range 15.63 to 35.27 g/cm2; with spreadability in range of 6.6 to 8.833 cm. swelling index of F3 was seen a maximum in 3 h of about 75.13%. The viscosity was in the range of 15240 to 56340 cps at 10 RPM. During in vitro release of all formulations, F1 and F5 showed a maximum in vitro drug release of 59.11% and 55.11% respectively in 8 h. The kinetic analysis of fitting the data in different model shows that the best formulation of F1 fits in the Higuchi model with regression coefficient (R2) of 0.998 and show non-fickian diffusion. The formulations were found stable. F1 and F5 provide a similar zone of inhibition like to market cream.

Conclusion: Tioconazole emulgel provide the better platform for delivery of hydrophobic drug for topical route and so able to produce better patient compliance. 


Keywords


Emulgel, Tioconazole, Hydrophobic drug, Topical drug delivery

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About this article

Title

DEVELOPMENT AND EVALUATION OF TIOCONAZOLE LOADED EMULGEL

Keywords

Emulgel, Tioconazole, Hydrophobic drug, Topical drug delivery

DOI

10.22159/ijap.2017v9i5.20046

Date

15-09-2017

Additional Links

Manuscript Submission

Journal

International Journal of Applied Pharmaceutics
Vol 9, Issue 5 (Aug-Sep), 2017 Page: 83-90

Online ISSN

0975-7058

Statistics

52 Views | 74 Downloads

Authors & Affiliations

Shailendra Kumar Sah
Department of Pharmaceutics, Division of Pharmaceutical Sciences, Shri Guru Ram Rai Institute of Technology and Science, Uttarakhand Technical University, Dehradun, 248001, Uttarakhand, India
India

Ashutosh Badola
Department of Pharmaceutics, Division of Pharmaceutical Sciences, Shri Guru Ram Rai Institute of Technology and Science, Uttarakhand Technical University, Dehradun, 248001, Uttarakhand, India
India

Sayantan Mukhopadhyay
Department of Pharmaceutics, Division of Pharmaceutical Sciences, Shri Guru Ram Rai Institute of Technology and Science, Uttarakhand Technical University, Dehradun, 248001, Uttarakhand, India
India


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