PREPARATION AND CHARACTERIZATION OF POLY (VINYL ALCOHOL)–POLY (VINYL PYRROLIDONE) MUCOADHESIVE BUCCAL PATCHES FOR DELIVERY OF LIDOCAINE HCL


Napaphak Jaipakdee, Thaned Pongjanyakul, Ekapol Limpongsa

Abstract


Objective: The objectives of this study were to prepare and characterize a buccal mucoadhesive patch using poly (vinyl alcohol) (PVA), poly (vinyl pyrrolidone) (PVP) as a mucoadhesive matrix, Eudragit S100 as a backing layer, and lidocaine HCl as a model drug.

Methods: Lidocaine HCl buccal patches were prepared using double casting technique. Molecular interactions in the polymer matrices were studied using attenuated total reflectance-fourier transform infrared spectroscopy (ATR-FTIR), differential scanning calorimetry (DSC) and X-ray diffractometry. Mechanical and mucoadhesive properties were measured using texture analyzer. In vitro permeation of lidocaine HCl from the patch was conducted using Franz diffusion cell.

Results: Both of the free and lidocaine HCl patches were smooth and transparent, with good flexibility and strength. ATR-FTIR, DSC and X-ray diffractometry studies confirmed the interaction of PVA and PVP. Mechanical properties of matrices containing 60% PVP were significantly lower than those containing 20% PVP (*P<0.05). Mucoadhesive properties had a tendency to decrease with the concentration of PVP in the patch. The patch containing 60% PVP had significantly lower muco-adhesiveness than those containing 20% PVP (*P<0.05). In vitro permeation revealed that the pattern of lidocaine HCl permeation started with an initial fast permeation, followed by a slower permeation rate. The initial permeation fluxes follow the zero-order model of which rate was not affected by the PVP concentrations in the PVA/PVP matrix.

Conclusion: Mucoadhesive buccal patches fabricated with PVA/PVP were successfully prepared. Incorporation of PVP in PVA/PVP matrix affected the strength of polymeric matrix and mucoadhesive property of patches.


Keywords


Poly (vinyl pyrrolidone), Poly (vinyl alcohol), Lidocaine HCl, Permeation, Buccal patch, Buccal drug delivery

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References


Park DM, Song YK, Jee JP, Kim HT, Kim CK. Development of chitosan-based ondansetron buccal delivery system for the treatment of emesis. Drug Dev Ind Pharm 2012; 38:1077-83.

Ikeuchi-Takahashi Y, Sasatsu M, Onishi H. Evaluation of matrix type mucoadhesive tablets containing indomethacin for the buccal application. Int J Pharm 2013;453:454-61.

Preis M, Woertz C, Schneider K, Kukawka J, Broscheit J, Roewer N, et al. Design and evaluation of bilayered buccal film preparations for local administration of lidocaine hydrochloride. Eur J Pharm Biopharm 2014;86:552-61.

Adhikari SN, Nayak BS, Nayak AK, Mohanty B. Formulation and evaluation of buccal patches for delivery of atenolol. AAPS PharmSciTech 2010;11:1038-44.

Yehia SA, El-Gazayerly ON, Basalious EB. Design and in vitro/in vivo evaluation of novel mucoadhesive buccal discs of an antifungal drug: the relationship between swelling, erosion, and drug release. AAPS PharmSciTech 2008;9:1207-17.

Dixit RP, Puthil SP. Oral strip technology: overview and future potential. J Controlled Release 2009;139:94-107.

Patel VF, Liu F, Brown MB. Advances in oral transmucosal drug delivery. J Controlled Release 2011;153:106-16.

Bruschi ML, de Freitas O. Oral bioadhesive drug delivery systems. Drug Dev Ind Pharm 2005;31:293–310.

Guo JH, Cooklok KM. The effects of backing materials and multilayered systems on the characteristics of mucoadhesive buccal patches. J Pharm Pharmacol 1996;48:255-7.

Cui Z, Mumper RJ. Bilayer films for mucosal (genetic) immunization via the buccal route in rabbits. Pharm Res 2002;19:947-53.

Satishbabu B, Srinivasan B. Preparation and evaluation of buccoadhesive films of atenolol. Indian J Pharm Sci 2008;70:175–9.

Saxena A, Tewari G, Saraf SA. Formulation and evaluation of mucoadhesive buccal patch of acyclovir utilizing inclusion phenomenon. Braz J Pharm Sci 2011;47:887-97.

Nafee NA, Ismail FA, Boraie NA, Mortada LM. Mucoadhesive buccal patches of miconazole nitrate: in vitro/in vivo performance and effect of ageing. Int J Pharm 2003;264:1-14.

Nappinnai M, Chandanbala R, Balaijirajan R. Formulation and evaluation of nitrendipine buccal films. Indian J Pharm Sci 2008;70:631–5.

Sadeq ZA, Rajab NA. Study the effect of different variables on the formulation of mucoadhesive buccal patches of captopril. Int J Appl Pharm 2017;9:16-21.

Peddapalli H, Chinnala KM, Banala N. Design and in vitro characterization of mucoadhesive buccal patches of duloxetine hydrochloride. Int J Pharm Pharm Sci 2017;9:52-9.

Abouhussein DMN, El-bary AA, Shalaby SH, El-nabarawi MA. Chitosan mucoadhesive buccal films: effect of different casting solvents on their physicochemical properties. Int J Pharm Pharm Sci 2017;8:206-13.

Abou Taleb MH. Thermal and spectroscopic studies of poly (N-vinyl pyrrolidone)/poly (vinyl alcohol) blend films. J Appl Polym Sci 2009;114:1202-7.

Jug M, Becirevic Lacan M, Bengez S. Novel cyclodextrin-based film formulation intended for buccal delivery of atenolol. Drug Dev Ind Pharm 2009;35:796-807.

Seabra AB, de Oliveira MG. Poly(vinyl alcohol) and poly(vinyl pyrrolidone) blended films for local nitric oxide release. Biomaterials 2004;25:3773-82.

Padula C, Nicoli S, Colombo P, Santi P. Single-layer transdermal film containing lidocaine: modulation of drug release. Eur J Pharm Biopharm 2007;66:422-8.

Malipeddi VR, Awasthi R, Ghisleni DD, de Souza Braga M, Kikuchi IS, de Jesus Andreoli Pinto T, et al. Preparation and characterization of metoprolol tartrate containing matrix-type transdermal drug delivery system. Drug Delivery Transl Res 2017;7:66-76.

Sawant PD, Luu D, Ye R, Buchta R. Drug release from hydroethanolic gels: Effect of drug's lipophilicity (Log P), polymer-drug interactions and solvent lipophilicity. Int J Pharm 2010;396:45-52.

Hu L, Silva SMC, Damaj BB, Martin R, Michniak-Kohn BB. Transdermal and transbuccal drug delivery systems: enhancement using iontophoretic and chemical approaches. Int J Pharm 2011;421:53-62.

Abu-Huwaij R, Assaf S, Salem M, Sallam A. Potential mucoadhesive dosage form of lidocaine hydrochloride: II. In vitro and in vivo evaluation. Drug Dev Ind Pharm 2007;33:437-48.

Ghosh S, Roy G, Mukherjee B. Dental mold: a novel formulation to treat common dental disorders. AAPS PharmSciTech 2009;10:692-702.

Kohda Y, Kobayashia H, Babaa Y, Yuasab H, Ozekib T, Kanayab Y, et al. Controlled release of lidocaine hydrochloride from buccal mucosa-adhesive films with solid dispersion. Int J Pharm 1997;158:147-55.

Varshosaz J, Karimzadeh S. Development of cross-linked chitosan films for oral mucosal delivery of lidocaine. Res Pharm Sci 2007;2:43-52.

Abu-Huwaij R, Assaf S, Salem M, Sallam A. Mucoadhesive dosage form of lidocaine hydrochloride: I. Mucoadhesive and physicochemical characterization. Drug Dev Ind Pharm 2007;33:855-64.

Okhamafe AO, York P. Studies of interaction phenomena in aqueous-based film coatings containing soluble additives using thermal analysis techniques. J Pharm Sci 1988;77:438-43.

Diaz-del Consuelo I, Jacques Y, Pizzolato G, Guy RH, Falson F. Comparison of the lipid composition of porcine buccal and esophageal permeability barriers. Arch Oral Biol 2005;50:981–7.

Diaz-del Consuelo I, Falson F, Guy RH, Jacques Y. Ex vivo evaluation of bioadhesive films for buccal delivery of fentanyl. J Controlled Release 2007;122:135–40.

Costa P, Lobo JMS. Modeling and comparison of dissolution profiles. Eur J Pharm Sci 2001;13:123–33.

Xiao S, Huang RYM, Feng X. Preparation and properties of trimesoyl chloride crosslinked poly(vinyl alcohol) membranes for pervaporation dehydration of isopropanol. J Membr Sci 2006;286:245–54.

Rajeswali N, Selvasekarapandian S, Karthikeyan S, Prabu M, Hirankumar G, Nithya H, et al. Conductivity and dielectric properties of polyvinyl alcohol–polyvinylpyrrolidone poly blend film using non-aqueous medium. ‎J Non-Cryst Solids 2011;357:3751-6.

Cassu SN, Felisberti MI. Poly(vinyl alcohol) and poly(vinyl pyrrolidone) blends: miscibility, microheterogeneity and free volume change. Polymer 1997;38:3907-11.

Powell MF. Lidocaine and lidocaine hydrochloride. In: American Pharmaceutical Association, editor. Analytical profiles of drug substances. Vol. 15. New York: Academic Press; 1986. p. 761-9.

Penido CA, Pacheco MT, Zangaro RA, Silveira LJr. Identification of different forms of cocaine and substances used in adulteration using near-infrared Raman spectroscopy and infrared absorption spectroscopy. J Forensic Sci 2015;60:171-8.

Aitken-Nichol C, Zhang F, McGinity JW. Hot melt extrusion of acrylic films. Pharm Res 1996;13:804-8.

Strawhecker KE, Manias E. Structure and properties of poly(vinyl alcohol)/Na+ montmorillonite nanocomposites. Chem Mater 2000;12:2943-9.

Badr Y, Mahmoud MA. Effect of PVA surrounding medium on ZnSe nanoparticles: Size, optical, and electrical properties. Spectrochimica Acta Part A 2006;65:584–90.

Eisa WH, Abdel-Moneam YK, Shabaka AA, Hosam AEM. In situ approach induced growth of highly monodispersed Ag nanoparticles within free-standing PVA/PVP films. Spectrochim Acta Part A 2012;95:341-6.

Mutalik S, Udupa N. Glibenclamide transdermal patches: physicochemical, pharmacodynamic, and pharmacokinetic evaluations. J Pharm Sci 2004;93:1577–94.

Rowe RC, Sheskey PJ, Quinn ME. Handbook of pharmaceutical excipients. 6th ed. Gurnee (IL): Pharmaceutical Press; 2009.

Karki S, Kim H, Na SJ, Shin D, Jo K, Lee J. Thin films as an emerging platform for drug delivery. Asian J Pharm Sci 2016;11:559–74.

Salamat-Miller N, Chittchang C, Johnston TP. The use of mucoadhesive polymers in buccal drug delivery. Adv Drug Delivery Rev 2005;57:1666-91.

Sudhakar Y, Kuotsu K, Bandyopadhyay AK. Buccal bioadhesive drug delivery–a promising option for orally less efficient drugs. J Controlled Release 2006;114:15–40.

Morales JO, McConville JT. Manufacture and characterization of mucoadhesive buccal films. Eur J Pharm Biopharm 2011;77:187-99.




About this article

Title

PREPARATION AND CHARACTERIZATION OF POLY (VINYL ALCOHOL)–POLY (VINYL PYRROLIDONE) MUCOADHESIVE BUCCAL PATCHES FOR DELIVERY OF LIDOCAINE HCL

Keywords

Poly (vinyl pyrrolidone), Poly (vinyl alcohol), Lidocaine HCl, Permeation, Buccal patch, Buccal drug delivery

DOI

10.22159/ijap.2018v10i1.23208

Date

06-01-2018

Additional Links

Manuscript Submission

Journal

International Journal of Applied Pharmaceutics
Vol 10, Issue 1 (Jan-Feb), 2018 Page: 115-123

Online ISSN

0975-7058

Statistics

71 Views | 19 Downloads

Authors & Affiliations

Napaphak Jaipakdee
Division of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Khon Kaen University, Khon Kaen, 40002, Thailand, Center for Research and Development of Herbal Health Products, Khon Kaen University, Khon Kaen, 40002, Thailand
Thailand

Thaned Pongjanyakul
Division of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Khon Kaen University, Khon Kaen, 40002, Thailand
Thailand

Ekapol Limpongsa
Division of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Khon Kaen University, Khon Kaen, 40002, Thailand, Center for Research and Development of Herbal Health Products, Khon Kaen University, Khon Kaen, 40002, Thailand
Thailand


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