IN VITRO PENETRATION TESTS OF TRANSETHOSOME GEL PREPARATIONS CONTAINING CAPSAICIN


Nuraini Azizah, Erny Sagita, Iskandarsyah Iskandarsyah

Abstract


Objective: Capsaicin is an active compound found in chili pepper and has been shown to have analgesic, antioxidant, anticancer, and anti-obesity
properties. To improve its penetration into the skin, capsaicin was prepared in a transethosome vesicle. Importantly, transethosomes are vesicles that
consist of phosphatidylcholine, surfactant, and ethanol. In this study, capsaicin was prepared in a transethosome vesicle using two different methods:
Direct transethosome formation and thin layer hydration. The aims of this study were to determine the effects of various methods of transethosome
formation on capsaicin characteristics and to evaluate the penetration capabilities of transethosome capsaicin gel.
Methods: Ultimately, transethosome formation via the thin layer method yielded more favorable characteristics; these formations had particle sizes
of 174.9±2.02 nm and an entrapment efficiency of 84.85±1.15%. The transethosome suspension was then developed into a gel formulation using 1%
carbomer. An in vitro penetration test was performed using a Franz diffusion cell of mice abdomen skin, and the performance of the transethosome
capsaicin gel was compared to that of the standard capsaicin gel.
Results: Penetration rate of capsaicin from either the transethosome gel preparation and the standard gel substance was 1549.68±49.6 and
846.05±10.1 μg/cm2, respectively.
Conclusions: According to these results, it can be concluded that gel preparations containing transethosome increase capsaicin penetration into the
skin.


Keywords


Capsaicin, Franz diffusion cell, Gel, Penetration, Transethosome.

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About this article

Title

IN VITRO PENETRATION TESTS OF TRANSETHOSOME GEL PREPARATIONS CONTAINING CAPSAICIN

Keywords

Capsaicin, Franz diffusion cell, Gel, Penetration, Transethosome.

DOI

10.22159/ijap.2017.v9s1.68_75

Date

30-10-2017

Additional Links

Manuscript Submission

Journal

International Journal of Applied Pharmaceutics
Vol. 9, Special Issue (Oct.), 2017 [PTMDS 2017] Page: 116-119

Online ISSN

0975-7058

Statistics

23 Views | 33 Downloads

Authors & Affiliations

Nuraini Azizah
Department of Pharmacy, Faculty of Pharmacy, Universitas Indonesia, Jakarta, Indonesia.
Indonesia

Erny Sagita
Department of Pharmacy, Faculty of Pharmacy, Universitas Indonesia, Jakarta, Indonesia.
Indonesia

Iskandarsyah Iskandarsyah
Department of Pharmacy, Faculty of Pharmacy, Universitas Indonesia, Jakarta, Indonesia.
Indonesia


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