PORPHYSOMES-A PARADIGM SHIFT IN TARGETED DRUG DELIVERY


Revathy B. Menon, Lakshmi V. S., Aiswarya M. U., Keerthana Raju, Sreeja C. Nair

Abstract


A novel drug delivery system is the one that ensures optimum dose at the right time, at the right location. Porphysomes are among those drug delivery systems. Porphysomes are a means of vesicular drug delivery systems. They are liposome-like structures composed completely of porphyrin lipid. The porphysomes encapsulates the active medicament in vesicular structure. They are having an aqueous core which can be loaded with the medicament. They have the capacity to destroy the disease tissues. They absorb the heat in the near infrared region and release this heat to destroy the diseased tissues. Porphysomes are having immense applications in the field of positron-electron therapy (PET), photoacoustic imaging, photothermal therapy etc. This review article discusses regarding the Porphysome-the drug delivery system, its advantages and disadvantages, composition, method of preparation, applications and various aspects related to the porphysomal drug delivery.


Keywords


Porphyrin, Phospholipid bilayer, Vesicular drug delivery, Imaging, Biophotonic property

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About this article

Title

PORPHYSOMES-A PARADIGM SHIFT IN TARGETED DRUG DELIVERY

Keywords

Porphyrin, Phospholipid bilayer, Vesicular drug delivery, Imaging, Biophotonic property

DOI

10.22159/ijap.2018v10i2.23493

Date

07-03-2018

Additional Links

Manuscript Submission

Journal

International Journal of Applied Pharmaceutics
Vol 10, Issue 2 (Mar-Apr), 2018 Page: 1-6

Online ISSN

0975-7058

Statistics

255 Views | 49 Downloads

Authors & Affiliations

Revathy B. Menon
Department of Pharmaceutics, Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, AIMS Health Science Campus, Kochi, India
India

Lakshmi V. S.
Department of Pharmaceutics, Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, AIMS Health Science Campus, Kochi, India
India

Aiswarya M. U.
Department of Pharmaceutics, Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, AIMS Health Science Campus, Kochi, India
India

Keerthana Raju
Department of Pharmaceutics, Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, AIMS Health Science Campus, Kochi, India
India

Sreeja C. Nair
Department of Pharmaceutics, Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, AIMS Health Science Campus, Kochi, India
India


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