• Sarwono At Department of Oral Biology, Faculty of Dentistry, Universitas Indonesia, Jakarta, Indonesia
  • Suniarti Df Department of Oral Biology, Faculty of Dentistry, Universitas Indonesia, Jakarta, Indonesia


Objective: This study aim to analyze the effect of the roselle calyx ethanol extract on oral mucosal wound healing.

Methods: Male Sprague Dawley rats (3 month, 150 g) were housed under standard temperature conditions (20–22°C). Punch biopsy wounds were inflicted on the inferior labial mucosal membrane of rats. All treatments (normal saline; 0.1% triamcinolone acetonide; and 3.75%, 7.5%, and 15% roselle calyx ethanol extract) were applied 2 times daily. Wounded areas were observed after 8 days of treatment. The specimen of the wounded area was prepared and microscopic slides were analyzed under a light microscope.

Results: The histological features of the groups treated with TA and 7.5% roselle calyx ethanol extract showed a similar formation of the epidermis layer and no lymphocytic infiltration of the lamina propria.

Conclusion: The application of 7.5% roselle calyx ethanol extract could stimulate oral mucosal wound healing.
Keywords: Roselle calyx, Ethanol extract, Triamcinolone acetonide, Wound healing activity, Anti-inflammatory, Oral mucous.


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How to Cite
At, S., & Df, S. (2018). ROSELLE CALYX ETHANOL EXTRACT STIMULATES ORAL MUCOSAL WOUND HEALING. International Journal of Applied Pharmaceutics, 9, 36-40.
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