Yogesh Pore, Madhuri Mane, Vaishnavi Mangrule, Atul Chopade, Pankaj Gajare


Objective: The objective of this study was to prepare and characterize etoricoxib (ECB) loaded Soluplus® nanocomposites to improve its physicochemical properties. The effect of polymer and surfactant concentration on particle size, in vitro percentage dissolution efficiency and the anti- inflammatory activity of nanocomposites were also investigated.

Methods: The nanocomposites were prepared by using a freeze drying technique. The analytical evidences for formulation of lyophilized nanocomposites in solid state were generated and confirmed by differential scanning calorimetry (DSC), fourier transformation infrared spectroscopy (FTIR), x-ray powder diffractometry (XPRD) and scanning electron microscopy (SEM). The in vitro drug release profile of nanocomposites was compared with pure ECB powder.

Results: The nanocomposites of ECB were ontained in a nano range with particle size and zeta potential of 63.5 nm and 46.5 mv, respectively. The solubility and dissolution of the nanocomposites were significantly (p < 0.001) improved as compared to ECB alone, evidenced by decreased log P values (1.90 ± 0.002) of the nanocomposites. The characterization studies revealed formation of amorphous nanocomposites of ECB with existence of physical interactions between drug and polymer. The anti- inflammatory activity of nanocomposites evaluated by carrageenan induced rat paw edema model demonstrated non significant (p > 0.05) increase in anti- inflammatory activity as compared to pure ECB.

Conclusion: From the results, it could be concluded that the formation of ECB nanocomposites with Soluplus® could be an effective and alternative approach to modify physicochemical properties of ECB.   


Etoricoxib; Soluplus®; nanocomposites; physicochemical properties; anti- inflammatory activity


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