• Yogesh Pore Department of Pharmaceutical Chemistry, Government College of Pharmacy, Ratnagiri, Maharashtra, 415 612, India
  • Madhuri Mane Department of Biopharmaceutics, Government College of Pharmacy, Karad, Maharashtra, 415 124, India.
  • Vaishnavi Mangrule Department of Pharmaceutical Chemistry, Government College of Pharmacy, Karad, Maharashtra, 415 124, India
  • Atul Chopade Department of Pharmacology, Rajarambapu College of Pharmacy, Kasegaon, Maharashtra, 415 404, India
  • Pankaj Gajare Department of Pharmaceutics, Rajaram and Tarabai Bandekar College of Pharmacy, Farmagudi, Ponda, Goa, 403 401, India


Objective: The objective of this study was to prepare and characterize etoricoxib (ECB) loaded Soluplus® nanocomposites to improve its physicochemical properties. The effect of polymer and surfactant concentration on particle size, in vitro percentage dissolution efficiency and the anti-inflammatory activity of nanocomposites were also investigated.

Methods: The nanocomposites were prepared by using a freeze-drying technique. The analytical evidence for the formulation of lyophilized nanocomposites in solid state were generated and confirmed by differential scanning calorimetry (DSC), fourier transformation infrared spectroscopy (FTIR), x-ray powder diffractometry (XPRD) and scanning electron microscopy (SEM). The in vitro drug release profile of nanocomposites was compared with pure ECB powder.

Results: The nanocomposites of ECB were contained in a nano range with particle size and zeta potential of 63.5 nm and 46.5 mv, respectively. The solubility and dissolution of the nanocomposites were significantly (p<0.001) improved as compared to ECB alone, evidenced by decreased log P values (1.90±0.002) of the nanocomposites. The characterization studies revealed the formation of amorphous nanocomposites of ECB with existence of physical interactions between drug and polymer. The anti-inflammatory activity of nanocomposites evaluated by carrageenan-induced rat paw edema model demonstrated nonsignificant (p>0.05) increase in anti-inflammatory activity as compared to pure ECB.

Conclusion: From the results, it could be concluded that the formation of ECB nanocomposites with Soluplus® could be an effective and alternative approach to modify the physicochemical properties of ECB.

Keywords: Etoricoxib, Soluplus®, Nanocomposites, Physicochemical properties, Anti-inflammatory activity


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How to Cite
Pore, Y., Mane, M., Mangrule, V., Chopade, A., & Gajare, P. (2018). PREPARATION, CHARACTERIZATION, AND EVALUATION OF ANTI-INFLAMMATORY ACTIVITY OF ETORICOXIB LOADED SOLUPLUS® NANOCOMPOSITES. International Journal of Applied Pharmaceutics, 10(6), 268-274.
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