PHARMACOKINETIC STUDIES OF A CHRONOTHERAPEUTIC DRUG DELIVERY SYSTEM OF LORNOXICAM BY LC-MS/MS METHOD


Sindhu Abraham, Rajamanickam Deveswaran, Jayaraman Anbu, Sharon Furtado, Bharath Srinivasan

Abstract


Objective: The objective of this study was to investigate differences in pharmacokinetic patterns of immediate release tablet (IR) and compression coated tablet (CCT) of lornoxicam, proposed for the chronotherapeutic treatment of rheumatoid arthritis.

Methods: The dosage forms were administered to two groups of white New Zealand rabbits (n=3), and the plasma drug levels were measured by liquid chromatography-tandem mass spectrometry (LC-MS/MS). Pharmacokinetic parameters like maximum concentration (Cmax), time is taken to reach maximum concentration (Tmax), area under the curve (AUC), elimination half-life (t1/2) and Mean Residence Time (MRT) were determined.

Results: In the case of IR tablets, the drug was detected within 15 min after oral administration and a Cmax of 1269.57±4.04 ng/ml were attained at 2±0.15 h. With CCT, the drug was detected only after 5 h and a Cmax of 1279.24±12.76 ng/ml were attained at 8±0.10 h. The CCT showed maximum drug release at the eighth hour in comparison to IR tablet which showed maximum release at the second hour of study.

Conclusion: The predominant lag time prior to drug release from CCT is an indication that it is consistent with the requirements of chronopharmaceutical drug delivery. The results suggest that the compression coated tablet is a promising approach for chronotherapeutic management of rheumatoid arthritis.


Keywords


lornoxicam, Chronotherapeutic, LC-MS/MS, Pharmacokinetic studies, New zealand rabbits

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About this article

Title

PHARMACOKINETIC STUDIES OF A CHRONOTHERAPEUTIC DRUG DELIVERY SYSTEM OF LORNOXICAM BY LC-MS/MS METHOD

Keywords

lornoxicam, Chronotherapeutic, LC-MS/MS, Pharmacokinetic studies, New zealand rabbits

DOI

10.22159/ijap.2018v10i6.27453

Date

04-09-2018

Additional Links

Manuscript Submission

Journal

International Journal of Applied Pharmaceutics
Articles In Press [Scheduled in Nov-Dec 2018] Page: 88-93

Online ISSN

0975-7058

Authors & Affiliations

Sindhu Abraham
Department of Pharmaceutics, Faculty of Pharmacy, M.S. Ramaiah University of Applied Sciences, MSR Nagar, MSRIT Post, Bengaluru-560054
India

Rajamanickam Deveswaran
Department of Pharmaceutics, Faculty of Pharmacy, M.S. Ramaiah University of Applied Sciences, MSR Nagar, MSRIT Post, Bengaluru-560054
India

Jayaraman Anbu
Department of Pharmacology, Faculty of Pharmacy, M.S. Ramaiah University of Applied Sciences, MSR Nagar, MSRIT Post, Bengaluru-560054
India

Sharon Furtado
Department of Pharmaceutics, Faculty of Pharmacy, M.S. Ramaiah University of Applied Sciences, MSR Nagar, MSRIT Post, Bengaluru-560054
India

Bharath Srinivasan
Department of Pharmaceutics, Faculty of Pharmacy, M.S. Ramaiah University of Applied Sciences, MSR Nagar, MSRIT Post, Bengaluru-560054
India


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