RESEARCH AND DEVELOPMENT OF DIAZEPAM SOLID DISPERSION POWDER USING NATURAL POLYMERS


Uditi Handa, Kamal Saroha

Abstract


Objective:  The objective of this study was to enhanced the solubility and dissolution rate of a poorly water-soluble drug by a solid dispersion (SD) technique, in order to conduct an investigation of the effect of these natural hydrophilic polymers on release mechanism from SD.

Methods:  The SD of diazepam (DZM) were prepared by using modified sodium alginate (SA) and modified guar gum (GG) in different drug:polymer ratios (1:1 & 1:2) by using physical mixture method (PM) and fusion method (FM). Further, the formulations were characterized for calibration curve, Fourier transform infra-red spectroscopy (FTIR) studies, % age practical yield, drug content estimation, solubility studies, dissolution studies.

Results:  The pure drug and SD were characterized by pre & post-formulations studies. The %age practical yield ranged from 92.9±0.25 to 49±0.57% and the drug content estimation ranged from 99.34±0.40 to 65.25±0.25 %. The FTIR studies shown that the compatibility between pure drug and natural polymers was stable. All the SD showed improved solubility as compare to pure drug (PD). SD prepared with modified SA (1:2) by PM and FM shown the huge enhancement of solubility and dissolution rate of the DZM. This can be specific the improvement in wettability and dispersibility, as well as enhances the drug amorphous fraction.

Conclusion: On the basis of research study, the SD technique shows the enhancement in the solubility of poorly water-soluble drug using natural polymers. SD containing natural polymers prepared with PM and FM shown the remarkable improvement in the release outline compared with PD, DZM.


Keywords


Key Words: Diazepam, Solid dispersions, Natural polymers, FTIR, Methods.

References


. Chowdary K.P.R, Sankar Ravi .K. Recent Research on solid dispersions employing superdisintegrants & surfactants as carrier. International journal of chemical science and technology 2015; 378-86.

. Singh S, Yadav L. A review on solid dispersion. International Journal of Pharmacy & Life science 2011; 1078-95.

. Kapoor B, Kaur R. Solid dispersion: An evolutionary approach for solubility enhancement of poorly water soluble drugs. International Journal of Recent Advances in Pharmaceutical Research 2012; 1-6.

. Tripathi K.D. Essential of medical pharmacology. 7thed, Jaypee brothers medical publication; 2013.p. 372-11.

. Shah S N. Development and validation of simple uv-spectrophotometric Method for quantitation of diazepam in api and solid dosage Formulation. World Journal of Pharmaceutical and Medical Research 2015; 1-4.

. Ada K. Properties of Diazepam (valium) 2007; 1-2.

. Hadžiabdić J, Elezović A, Hadžović S, Vehabović M. The solubility - intrinsic dissolution rate of diazepam and inclusion complexes diazepam with 2 hydroxypropyl-β-cyclodextrin. International Journal of Science. Technology and Society 2013; 24-35.

. Patel S.A. Simultaneous spectrophotometric determination of diazepam and propranolol hydrochloride in tablets. Current research in pharmaceutical sciences 2011; 01: 25-30.

Daharwal S. J. Development and Validation of UV Spectrophotometric Method for Simultaneous Estimation of Diazepam and Propranolol in Bulk Drug and Its Formulations. Asian J. Pharm. Ana. Vol 2013; 20-23.

thefisheriesblog.com

. Josep E.R. Use of Micellar Mobile Phases for the Chromatographic Determination of Clorazepate, Diazepam, and Diltiazem in Pharmaceuticals. Journal of Chromatographic Science 2000; 30: 521-27.

. IP. Indian Pharmacopoeia commission. Ghaziabad 2007; 2: 1013-14.

. Nebojša D. Cekić, Sanela M. Đorđević, Saša R. Savić. A full factorial design in the formulation of diazepam parenteral nanoemulsions: physicochemical characterization and stability evaluation. Advanced technologies 2015; 69-77.

. Manogar P.G, Hari BNV, Devi D.R. Emerging Liquisolid Compact Technology for Solubility Enhancement of BCS Class-II sDrug. J. Pharm. Sci. & Res 2011; 1604-11.

. Sylaja.B and Srinivasan.S. Experimental and theoretical investigation of spectroscopic properties of diazepam. International Journal of ChemTech Research 2012; 361-76.

. Alway B, Sangchantra R, Stewart PJ. Modelling the dissolutionof diazepam in lactose interactive mixtures. Int JPharm 1996; 130: 213-24.

. Shanmugam. Natural polymers and their applications 2005; 478-81.

. Singh Anupama. Release Behavior of Drugs from Various Natural Gums and Polymers. Polimery w Medycynie,T. 2011;73-80.

. FMC biopolymer. Alginate. Nova Matrix Ultrapure Biopolymer Systems 2011;1-2.

. Howlader Md., Chakrabarty JK, Faisal KS. Enhancing dissolution profile of diazepam using hydrophilic polymers by solid dispersion technique. International Current Pharmaceutical Journal 2012;423-30.

. Kaza R., Kumar AG, Charan YR. A Study on the Dissolution enhancement of Gliclazide using natural polymers. International Journal of Innovative Pharmaceutical Research 2012;194-98.

. Gupta A and Verma D.K. Guar gum and their derivatives: a research profile. International Journal of Advanced Research 2014; 680-90.

. Prasad S.S, Rao K.M. Synthesis and Characterisation of Guar Gum-g-Poly(Acrylamidoglycolic acid) by Redox Initiator. Indian Journal of Advances in Chemical Science 2012; 1: 28-32.

. Tripathi S, Das M.K. Guar gum: Present status and applications. Journal of Pharmaceutical and Scientific Innovation 2013; 24-28.

. Shejul A, Deshmane S, Biyani K. Modified natural carrier in solid dispersion for enhancement of solubility of poorly water soluble drugs. Journal of Drug Delivery & Therapeutics 2014; 111-16.

. Kaza R., Raju YP. Dissolution enhancement of valsartan using natural polymers by solid dispersion technique. Scholars Research Library De Pharmacia Lettre 2013;126-34.




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