PREPARATION AND EVALUATION OF ATENOLOL-β-CYCLODEXTRIN ORALLY DISINTEGRATING TABLETS USING CO-PROCESS CROSPOVIDONE-SODIUM STARCH GLYCOLATE


Nani Parfati, Karina Citra Rani, Nathanael Charles, Valencia Geovany

Abstract


Objective: The aim of this current research was to formulate and analyze the characteristics of atenolol-β-cyclodextrin which using co-process crospovidone-sodium starch glycolate as the disintegrants. Evaluation which has been conducted on orally disintegrating tablets consist of wetting time, water absorption ratio, in vitro dispersion time, and dissolution.

Methods: Inclusion complex of atenolol-β-cyclodextrin which were prepared using solvent evaporation method, then formulated using co-processed crospovidone-sodium starch glycolate 1:1 (formula 1) and 1:2 (formula 2) into orally disintegrating tablets by direct compression technique. Orally disintegrating tablets of atenolol-β-cyclodextrin using a physical mixture of crospovidone-sodium starch glycolate 1:1 (formula 3), 1:2 (formula 4) was also prepared as a control. The prepared formulations (F1-F4) were evaluated by several parameters such as wetting time, water absorption ratio, in vitro dispersion time, and dissolution.

Results: Orally disintegrating tablets of atenolol-β-cyclodextrin using co-processed crospovidone-sodium starch glycolate 1:1 (formula 1) showed shorter wetting time (53.53±2.26 seconds) and in vitro dispersion time (47.44±2.49 seconds) compare to the other formulas. Formula 1 also exhibited the highest dissolution efficiency compare to the formula which was used in the physical mixture. The results of this study also revealed that there was a high correlation between in vitro dispersion time and dissolution efficiency of atenolol-β-cyclodextrin orally disintegrating tablets.

Conclusion: Orally disintegrating tablets of atenolol-β-cyclodextrin showed enhanced dissolution efficiency due to the presence of inclusion complex and co-processed crospovidone-sodium starch glycolate. Formula 1 was found to be the best formula in this study. This formula effectively reduces in vitro dispersion time, hence the dissolution efficiency became higher.


Keywords


Atenolol, orally disintegrating tablets, Inclusion complex, Co-processed, crospovidone, sodium starch glycolate

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About this article

Title

PREPARATION AND EVALUATION OF ATENOLOL-β-CYCLODEXTRIN ORALLY DISINTEGRATING TABLETS USING CO-PROCESS CROSPOVIDONE-SODIUM STARCH GLYCOLATE

Keywords

Atenolol, orally disintegrating tablets, Inclusion complex, Co-processed, crospovidone, sodium starch glycolate

DOI

10.22159/ijap.2018v10i5.27982

Date

08-09-2018

Additional Links

Manuscript Submission

Journal

International Journal of Applied Pharmaceutics
Vol 10, Issue 5 (Sep-Oct), 2018 Page: 190-194

Online ISSN

0975-7058

Authors & Affiliations

Nani Parfati
Department of Pharmaceutics, Faculty of Pharmacy, University of Surabaya, Kalirungkut, Surabaya-60293, East Java, Indonesia
Indonesia

Karina Citra Rani
Department of Pharmaceutics, Faculty of Pharmacy, University of Surabaya, Kalirungkut, Surabaya-60293, East Java, Indonesia
Indonesia

Nathanael Charles
Department of Pharmaceutics, Faculty of Pharmacy, University of Surabaya, Kalirungkut, Surabaya-60293, East Java, Indonesia
Indonesia

Valencia Geovany
Department of Pharmaceutics, Faculty of Pharmacy, University of Surabaya, Kalirungkut, Surabaya-60293, East Java, Indonesia
Indonesia


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