C H Sai Sanjay, Vivek Ghate, Shaila A. Lewis


Mesoporous silica particles (MSP) have been reported to be applicable in diverse situations pertaining to the delivery of several drug molecules. MSP have established themselves in treating diseases with oral, dermal and parenteral modes of administration. Recently, dermal delivery using MSP have gained a considerable amount of interest owing to the increase in drug stability, permeation and ease of functionalization. MSP, in general, have a very high capability of delivering actives ranging from small molecules like drugs and amino acids to larger peptides, vaccines and antibodies. The applicability of MSP in achieving desired cosmetic and health-related outcomes depends on the careful tuning of their pore size, surface area, shape and overall physicochemical properties. This review provides comprehensive details of the recent developments in the fabrication of MSP, their characteristic features and, applications in dermal drug delivery. Studies on establishing the safety profile of MSP have also been summarized in the review.


Mesoporous Silica, Dermal Delivery, Permeation, Pore Size, Functionalization

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Soboleva T, Zhao X, Malek K, Xie Z, Navessin T, Holdcroft S. On the micro-, meso-, and macroporous structures of polymer electrolyte membrane fuel cell catalyst layers. ACS Appl Mater Interfaces 2010;2:375–84.

Keshavarz M, Ahmad N. Characterization and modification of mesoporous silica nanoparticles prepared by sol-gel. J Nanopart 2013;2013:1–4. 102823.

Lin YC, Lin LY, Gao MY, Fang YP. Mesoporous silica nanoparticles synthesized from liquid crystal display manufacturing extracts as a potential candidate for a drug delivery carrier: evaluation of their safety and biocompatibility. Int J Nanomed 2013;8:3833–42.

Suzuki T, Kuroda K. Deposition of single-crystalline mesoporous silica particles and the in-plane arrangement of mesocages over particles on a cleaved mica surface. J Mater Chem 2007;17:4762-7.

Natarajan SK, Selvaraj S. Mesoporous silica nanoparticles: importance of surface modifications and its role in drug delivery. RSC Adv 2014;4:14328-34.

Liberman A, Mendez N, Trogler WC, Kummel AC. Synthesis and surface functionalization of silica nanoparticles for nanomedicine. Surf Sci Rep 2014;69:132–58.

Wu S, Mou C, Lin H. Synthesis of mesoporous silica nanoparticles. Chem Soc Rev 2013;42:3862-75.

Watermann A, Brieger J. Silica nanoparticles as drug delivery vehicles in cancer. Nanomaterials (Basel, Switzerland) 2017; 7:1-17.

Arap W, Pasqualini R, Montalti M, Petrizza L, Prodi L, Rampazzo E, et al. Luminescent silica nanoparticles for cancer diagnosis. Curr Med Chem 2013;20:2195–211.

Bouamrani A, Hu Y, Tasciotti E, Li L, Chiappini C, Liu X, et al. Mesoporous silica chips for selective enrichment and stabilization of low molecular weight proteome. Proteomics 2010;10:496–505.

Yu M, Niu Y, Zhang J, Zhang H, Yang Y, Taran E, et al. Size-dependent gene delivery of amine-modified silica nanoparticles. Nano Res 2016;9:291–305.

Gimenez C, Torre L, Gorbe M, Aznar E, Sancenon F, Murguia JR, et al. Gated mesoporous silica nanoparticles for the controlled delivery of drugs in cancer cells. Langmuir 2015;31:3753–62.

Song Y, Li Y, Xu Q, Liu Z. Mesoporous silica nanoparticles for stimuli-responsive controlled drug delivery: advances, challenges, and outlook. Int J Nanomed 2017;12:87–110.

Teng Z, Su X, Zheng Y, Sun J, Chen G, Tian C, et al. Mesoporous silica hollow spheres with ordered radial mesochannels by a spontaneous self-transformation approach. Chem Mater 2013;25:98–105.

Bharti C, Nagaich U, Pal AK, Gulati N. Mesoporous silica nanoparticles in target drug delivery system: a review. Int J Pharm Invest 2015;5:124–33.

Chiu HY, Leonhardt H, Bein T. Synthesis and functionalization of ordered large-pore mesoporous silica nanoparticles for biomedical applications. Chem Ing Tech 2017;89:876–86.

Limnell T, Santos HA, Makila E, Heikkila T, Salonen J, Murzin DY, et al. Drug delivery formulations of ordered and nonordered mesoporous silica: comparison of three drug loading methods. J Pharm Sci 2011;100:3294–306.

Lin YS, Abadeer N, Haynes CL. Stability of small mesoporous silicananoparticles in biological media. Chem Commun 2011; 47:532–4.

Choi Y, Lee JE, Lee JH, Jeong JH, Kim J. A biodegradation study of SBA-15 microparticles in simulated body fluid and in vivo. Langmuir 2015;31:6457–62.

Richardson M. Understanding the structure and function of the skin. Nurs Times 2003;99:46–8.

Otberg N, Patzelt A, Rasulev U, Hagemeister T, Linscheid M, Sinkgraven R, et al. The role of hair follicles in the percutaneous absorption of caffeine. Br J Clin Pharmacol 2008;65:488–92.

Konradsdottir F, Ogmundsdottir H, Sigurdsson V, Loftsson T. Drug targeting to the hair follicles: a cyclodextrin-based drug delivery. AAPS PharmSciTech 2009;10:266–9.

Watkinson AC, Kearney MC, Quinn HL, Courtenay AJ, Donnelly RF. Future of the transdermal drug delivery market–have we barely touched the surface? Expert Opinion Drug Delivery 2016;13:523–32.

Ernawati L, Balgis R, Ogi T, Okuyama K. Tunable synthesis of mesoporous silica particles with unique radially oriented pore structures from tetramethyl orthosilicate via oil–water emulsion process. Langmuir 2017;33:783–90.

Yamada H, Urata C, Aoyama Y, Osada S, Yamauchi Y, Kuroda K. Preparation of colloidal mesoporous silica nanoparticles with different diameters and their unique degradation behavior in static aqueous systems. Chem Mater 2012;24:1462–71.

Lodha A, Lodha M, Patel A, Chaudhuri J, Dalal J, Edwards M, et al. Synthesis of mesoporous silica nanoparticles and drug loading of poorly water soluble drug cyclosporin A. J Pharm BioAllied Sci 2012;4(Suppl 1):S92-4.

Kaasalainen M, Aseyev V, Haartman E, Karaman DS, Makila E, Tenhu H, et al. Size, stability, and porosity of mesoporous nanoparticles characterized with light scattering. Nanoscale Res Lett 2017;12:74.

Abd-elbary, Nabarawi MAE, Hassen DH, Taha AA. Inclusion and characterization of ketoprofen into different mesoporous silica nanoparticles using three loading methods. Int J Pharm Pharm Sci 2014;6:189-91.

Bagwe RP, Lisa R, Hilliard LR, Tan W. Surface modification of silica nanoparticles to reduce aggregation and nonspecific binding. Langmuir 2006;22:4357-62.

Warther D, Jimenez CM, Raehm L, Gerardin C, Durand J, Morere A, et al. Small sized mesoporous silica nanoparticles functionalized with mannose for retinoblastoma cell imaging. RSC Adv 2014;4:37171-9.

Rancan F, Gao Q, Graf C, Troppens S, Hadam S, Hackbart S, et al. Skin penetration and cellular uptake of amorphous silica nanoparticles with variable size, surface functionalization, and colloidal stability. ACS Nano 2012;6:6829–42.

Dianzani C, Zara GP, Maina G, Pettazzoni P, Pizzimenti S, Rossi F, et al. Drug delivery nanoparticles in skin cancers. BioMed Res Int 2014;2014:1-13.

Lademann J, Patzelt A, Richter H, Antoniou C, Sterry W, Knorr F. Determination of the cuticula thickness of human and porcine hairs and their potential influence on the penetration of nanoparticles into the hair follicles. J Biomed Opt 2009;14:210-4.

Yu T, Malugin A, Ghandehari H. Impact of silica nanoparticle design on cellular toxicity and hemolytic activity. ACS Nanol 2011;5:5717–28.

Sharmiladevi S, Priya AS, Sujitha MV. Synthesis of mesoporous silica nanoparticles and drug loading for gram positive and gram negative bacteria. Int J Pharm Pharm Sci 2016;8:196-201.

Braun K, Pochert A, Linden M, Davoudi M, Schmidtchen A, Nordstrom R, et al. Membrane interactions of mesoporous silica nanoparticles as carriers of antimicrobial peptides. J Colloid Interface Sci 2016;475:161–70.

Morry J, Ngamcherdtrakul W, Gu S, Goodyear SM, Castro DJ, Reda MM, et al. Dermal delivery of HSP47 siRNA with NOX4-modulating mesoporous silica-based nanoparticles for treating fibrosis. Biomaterials 2015;66:41–52.

Ahmadi E, Dehghannejad N, Hashemikia S, Ghasemnejad M, Tabebordbar H. Synthesis and surface modification of mesoporous silica nanoparticles and its application as carriers for sustained drug delivery. Drug Delivery 2014;21:164–72.

Musso GE, Bottinelli E, Celi L, Magnacca G, Berlier G. Influence of surface functionalization on the hydrophilic character of mesoporous silica nanoparticles. Physical Chem Chem Phys 2015;17:13882–94.

Ngo MA, O’Malley M, Maibach HI. Perspectives on percutaneous penetration of nanomaterials. In Nanotechnology in Dermatology. New York, NY: Springer New York; 2013. p. 63–86.

Boonen J, Baert B, Lambert J, De Spiegeleer B. Skin penetration of silica microparticles. Die Pharmazie 2011;66:463–4.

Nohynek GJ, Lademann J, Ribaud C, Roberts MS. Grey goo on the skin? nanotechnology, cosmetic and sunscreen safety. Crit Rev Toxicol 2007;37:251–77.

Eskandar NG, Simovic S, Prestidge CA. Chemical stability and phase distribution of all-trans-retinol in nanoparticle-coated emulsions. Int J Pharm 2009;376:186–94.

Khan MA, Wallace WT, Islam SZ, Nagpure S, Strzalka J, Littleton JM, et al. Adsorption and recovery of polyphenolic flavonoids using TiO 2-functionalized mesoporous silica nanoparticles. ACS Appl MaterInterfaces 2017;9:32114–25.

Scalia S, Franceschinis E, Bertelli D, Iannuccelli V. Comparative evaluation of the effect of permeation enhancers, lipid nanoparticles and colloidal silica on in vivo human skin penetration of quercetin. Skin Pharmacol Physiol 2013;26:57–67.

Ngo MA, O'Malley M, Maibach HI. Percutaneous absorption and exposure assessment of pesticides. J Appl Toxicol 2010;30:91-114.

Götz C, Pfeiffer R, Tigges J, Ruwiedel K, Hubenthal U, Merk HF, et al. Xenobiotic metabolism capacities of human skin in comparison with a 3D epidermis model and keratinocyte-based cell culture as in vitro alternatives for chemical testing: activating enzymes (Phase I). Exp Dermatol 2012;21:358–63.

Jadhav SA, Cabanas MV, Manzano M, Vallet-Regi M. Controlled post-synthesis grafting of thermoresponsive poly(N-isopropylacrylamide) on mesoporous silica nanoparticles. Pol Adv Technol 2015;26:1070–5.

Paris JL, Cabanas MV, Manzano M, Vallet-Regi M. Polymer-grafted mesoporous silica nanoparticles as ultrasound-responsive drug carriers. ACS Nanol 2015;9:11023–33.

Soto RJ, Yang L, Schoenfisch MH. Functionalized mesoporous silica via an aminosilane surfactant ion exchange reaction: controlled scaffold design and nitric oxide release. ACS Appl Mater Interfaces 2016;8:2220–31.

Feinle A, Leichtfried F, Straber S, Husing N. Carboxylic acid-functionalized porous silica particles by a co-condensation approach. J Sol Gel Sci Technol 2017;81:138–46.

Croissant JG, Cattoen X, Man MWC, Durand J, Khasab NM. Syntheses and applications of periodic mesoporous organosilica nanoparticles. Nanoscale 2015;7:20318–34.

Croissant JG, Fatieiev Y, Khashab NM. Degradability and clearance of silicon, organosilica, silsesquioxane, silica mixed oxide, and mesoporous silica nanoparticles. Adv Mater 2017;29:1604634.

Zhang Y, Hu L, Yu D, Gao C. Influence of silica particle internalization on adhesion and migration of human dermal fibroblasts. Biomaterials 2010;31:8465–74.

Crosera M, Bovenzi M, Mania G, Adami G, Zanette C, Florio C, et al. Nanoparticle dermal absorption and toxicity: a review of the literature. Int Arch Occup Environ Health 2009;82:1043–55.

Hudson SP, Padera RF, Langer R, Kohane DS. The biocompatibility of mesoporous silicates. Biomaterials 2008;29:4045–55.

Pandey P, Dahiya M. A brief review on inorganic nanoparticles. J Cri Rev 2016;3:18-26.

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Mesoporous Silica, Dermal Delivery, Permeation, Pore Size, Functionalization





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International Journal of Applied Pharmaceutics
Articles In Press [Scheduled in Nov-Dec 2018] Page: 23-26

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Authors & Affiliations

C H Sai Sanjay
Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal- 576104, India

Vivek Ghate
Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal- 576104, India

Shaila A. Lewis
Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal- 576104, India


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