MESOPOROUS SILICA PARTICLES FOR DERMAL DRUG DELIVERY: A REVIEW


C H Sai Sanjay, Vivek Ghate, Shaila A. Lewis

Abstract


Mesoporous silica particles (MSP) have been reported to be applicable in diverse situations pertaining to the delivery of several drug molecules. MSP have established themselves in treating diseases with oral, dermal and parenteral modes of administration. Recently, dermal delivery using MSP have gained a considerable amount of interest owing to the increase in drug stability, permeation and ease of functionalization. MSP, in general, have a very high capability of delivering actives ranging from small molecules like drugs and amino acids to larger peptides, vaccines and antibodies. The applicability of MSP in achieving desired cosmetic and health-related outcomes depends on the careful tuning of their pore size, surface area, shape and overall physicochemical properties. This review provides comprehensive details of the recent developments in the fabrication of MSP, their characteristic features and, applications in dermal drug delivery. Studies on establishing the safety profile of MSP have also been summarized in the review.


Keywords


Mesoporous Silica, Dermal Delivery, Permeation, Pore Size, Functionalization

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References


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About this article

Title

MESOPOROUS SILICA PARTICLES FOR DERMAL DRUG DELIVERY: A REVIEW

Keywords

Mesoporous Silica, Dermal Delivery, Permeation, Pore Size, Functionalization

DOI

10.22159/ijap.2018v10i6.28633

Date

04-09-2018

Additional Links

Manuscript Submission

Journal

International Journal of Applied Pharmaceutics
Articles In Press [Scheduled in Nov-Dec 2018] Page: 23-26

Online ISSN

0975-7058

Authors & Affiliations

C H Sai Sanjay
Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal- 576104, India
India

Vivek Ghate
Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal- 576104, India

Shaila A. Lewis
Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal- 576104, India
India


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