SWELLING BEHAVIOR OF POLY (AAM_MA) HYDROGEL MATRIX AND STUDY EFFECTS PH AND IONIC STRENGTH, ENFORCEMENT IN CONTROLLED RELEASE SYSTEM


Faiq F. Karam, Asawer A. Mhammed Alzayd

Abstract


Objective: The objective of this study was to estimate the performance of Acrylamide-malice acid (AAM_MA) hydrogel preparatory by free radical polymerization to loading/release Atenolol and Ciprofloxacin drugs from aqueous solution to be used in a controlled release system.

Methods: Free radical polymerization method has been used to prepare (AAM-MA) hydrogel. The prepared hydrogel was characterized by Fourier transform infrared (FTIR), Thermal Gravimetric Analysis/Derivative Thermal Gravimetric (TGA/DTG) and Field Emission Scanning Electron Microscopy (FE-SEM) techniques. The pH-dependent swelling behavior was investigated in addition to the effective ionic strength on adsorption and release system of the drug in vitro.

Results: Results showed that the highest swelling ration in pH=7.4 and the same value of pH for the release of the drug. Thermal analysis test for prepared hydrogel showed good thermal stability. The hydrogel showed a negative effect with an increase saline contact Calcium carbonate appeared to have highly effect on releasing drugs from the polymeric network.

Conclusion: Higher ability of poly (AAM-MA) hydrogel to act as a carrier for the Ciprofloxacin and Atenolol with highest swelling and releasing under following conditions: at pH 7.4, at temperature 37 °C and the effect of ionic strength (charge/ratio) which indicate that the smaller radius have less effect on release and the largest charge have negative effect on release ratio that attributed to cation formation inter and intra complex surface hydrogel.

 


Keywords


Ciprofloxacin, Atenolol, Swelling ratio, Drug carriers, Polymeric network, Controlled release system, Biological half-life

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References


Feldman D. Polymer history. Des Monomers Polym 2008;11:1-15.

Hamid AMS, Rehman K, Chen S. Natural and synthetic polymers as drug carriers for delivery of therapeutic proteins. Polym Rev 2015;55:371-406.

Kaur R, Kaur S. Role of polymers in drug delivery. J Drug Delivery Ther 2014;4:32-6.

Srivastava A, Yadav T, Sharma S, Nayak A, Kumari AA, Mishra N. Polymers in drug delivery. J Br Med 2015;4:69.

Zhang Y, Sun T, Jiang C. Biomacromolecules as carriers in drug delivery and tissue engineering. Acta Pharm Sin B 2017;8:34–50.

Larraneta E, Stewart S, Ervine M, Al-Kasasbeh R, Donnelly RF. Hydrogels for hydrophobic drug delivery classification, synthesis and applications. J Funct Biomater 2018;9:1-20.

Sivapriya V, Ponnarmadha S, Abdul Azeezand N, Sudarshanadeepa V. Novel nanocarriers for ethnopharmacological formulations. Int J Appl Pharm 2018;10:26-30.

Caccavo D, Cascone S, Lamberti G, Barba AA. Hydrogels: experimental characterization and mathematical modeling of their mechanical and diffusive behavior. Chem Soc Rev 2018;47:2357-73.

Leon O, Munoz-Bonilla A, Soto D, Ramirez J, Marquez Y, Colina M, et al. Preparation of oxidized and grafted chitosan superabsorbents for urea delivery. J Polym Environ 2018;26:728-39.

Yahia L, Chirani N, Gritsch L, Motta FL, Fare S. History and applications of hydrogels. J Biomedical Sci 2015;4:1-23.

Mohy Eldin MS, Omer AM, Wassel MA, Tamer TM, Abd Elmonem MS, Ibrahim SA. Novel smart pH sensitive chitosan grafted alginate hydrogel microcapsules for oral protein delivery: i. preparation and characterizationoriginal. Int J Pharm Pharm Sci 2015;7:320-6.

Lal S, Datta M. In vitro prolonged gastric residence and sustained release of atenolol using novel clay-polymer nanocomposite. Appl Clay Sci 2015;114:412-21.

Marques SC, Mestre AS, Machuqueiro M, Gotvajn AZ, Marinsek M, Carvalho AP. Apple tree branches derived activated carbons for the removal of β-blocker atenolol. Chem Eng J 2018;345:669-78.

Dehdashti B, Amin MM, Pourzamani H, Rafati L, Mokhtari M. Removal of atenolol from aqueous solutions by multiwalled carbon nanotubes modified with ozone: kinetic and equilibrium study. Wat Sci Tech 2018;3:1-14.

Ahmed MB, Zhou JL, Ngo HH, Guo W. Adsorptive removal of antibiotics from water and wastewater: progress and challenges. Sci Total Environ 2015;532:112-26.

Wang L, Chen G, Ling C, Zhang J, Szerlag K. Adsorption of ciprofloxacin on to bamboo charcoal: effects of pH, salinity, cations, and phosphate. Environ Prog Sustain Energy 2017;36:1108-15.

Vidyavathi M, Srividya G. A review on ciprofloxacin. Int J Appl Pharm 2018;10:6-10.

Qi X, Wei W, Su T, Zhang J, Dong W. Fabrication of a new polysaccharide-based adsorbent for water purification. Carbohydr Polym 2018;195:368-77.

Murali Mohan Y, Sudhakar K, Keshava Murthy PS, Mohan Raju K. Swelling properties of chemically crosslinked poly (acrylamide-co-maleic acid) hydrogels. Int J Polym Mater 2006;55:513-36.

Ngeno EC, Orata F, Lilechi DB, Shikuku VO, Kimosop S. Adsorption of caffeine and ciprofloxacin onto pyrolytically derived water hyacinth biochar: isothermal, kinetic and thermodynamic studies. J Chem Chem Eng 2016;10:185-94.

Ali DJ, Al-Bayati RA, Alani RR. Adsorption-desorption and theoretical study of propranolol hydrochloride drug on chitosan and cellulose acetate surfaces. Br J Pharm Res 2016;10:1-8.

Abdel Bary EM, Harmal AN, Saeed A, Gouda MA. Design, synthesis, characterization, swelling and in vitro drug release behavior of composite hydrogel beads based on methotrexate and chitosan incorporating antipyrine moiety. Polym Plast Technol Eng 2018;57:1-9.

Kim B, Lim SH, Ryoo W. Preparation and characterization of pH-sensitive anionic hydrogel microparticles for oral protein-delivery applications. J Biomater Sci Polym Ed 2009;20:427-36.

Eid M. Gamma radiation preparation of poly (Acrylamide/Maleic Acid/Gelatin) hydrogels for adsorption of chromium ions from wastewater. Asian J Pharm Sci Biotechnol 2015;1:9-14.

Abdel-Aziz HM, Hanafi HA, Abozahra SF, Siyam T. Preparation of poly (acrylamide-maleic Acid) resin by template polymerization and its use for adsorption of Co (II) and Ni (II). Int J Polym Mater 2010;60:89-101.

Rao DK, Damodharam T, Yadav JS, Suresh Babu P. Removal of atenolol (β-blocker) from the aqueous phase by sorption onto activated charcoal. Int J Pharm Chem Sci 2013:2:26-32.‏

Jalil MER, Baschini M, Sapag K. Influence of pH and antibiotic solubility on the removal of ciprofloxacin from aqueous media using montmorillonite. Appl Clay Sci 2015;114:69-76.

Bazhan Z, Ghodsi FE, Mazloom J. The surface wettability and improved electrochemical performance of the nanostructured CoxFe3− xO4 thin film. Surf Coat Technol 2017;309:554-62.

Zheng Y, Cosgrove DJ, Ning G. High-resolution field emission scanning electron microscopy (FESEM) imaging of cellulose microfibril organization in plant primary cell walls. Microsc Microanal 2017;23:1048-54.

Ferriol M, Gentilhomme A, Cochez M, Oget N, Mieloszynski JL. Thermal degradation of poly (methyl methacrylate)(PMMA): modelling of DTG and TG curves. Polym Degrad Stab 2003;79:271-81.

Tang Y, Wang X, Zhu L. Removal of methyl orange from aqueous solutions with poly (acrylic acid-co-acrylamide) superabsorbent resin. Polym Bull 2013;70:905-18.

Khan A, Othman MBH, Razak KA, Akil HM. Synthesis and physicochemical investigation of chitosan-PMAA-based dual-responsive hydrogels. J Polym Res 2013;20:273-82.

Bajpai SK, Johnson S. Poly (acrylamide‐co‐maleic acid) hydrogels for removal of Cr (VI) from aqueous solutions, part 1: synthesis and swelling characterization. J Appl Polym Sci 2006;100:2759-69.

Ramana Reddy KV, Nagabhushanam MV. Process and parameters are affecting drug release performance of prepared cross-linked alginate hydrogel beads for ezetimibe. Int J Pharm Pharm Sci 2017;9:254-62.

Che Y, Li D, Liu Y, Ma Q, Tan Y, Yue Q, et al. Physically cross-linked pH-responsive chitosan-based hydrogels with an enhanced mechanical performance for controlled drug delivery. RSC Adv 2016;6:106035-45.

Qi X, Li J, Wei W, Zuo G, Su T, Pan X, et al. Cationic salecan-based hydrogels for release of 5-fluorouracil. RSC Adv 2017;7:14337-47.




About this article

Title

SWELLING BEHAVIOR OF POLY (AAM_MA) HYDROGEL MATRIX AND STUDY EFFECTS PH AND IONIC STRENGTH, ENFORCEMENT IN CONTROLLED RELEASE SYSTEM

Keywords

Ciprofloxacin, Atenolol, Swelling ratio, Drug carriers, Polymeric network, Controlled release system, Biological half-life

DOI

10.22159/ijap.2018v10i6.28724

Date

29-10-2018

Additional Links

Manuscript Submission

Journal

International Journal of Applied Pharmaceutics
Articles In Press [Scheduled in Nov-Dec 2018] Page: 318-325

Online ISSN

0975-7058

Authors & Affiliations

Faiq F. Karam
Department of Chemistry, College of Science, University of Al-Qadisiyah, Iraq
Iraq

Asawer A. Mhammed Alzayd
College of Veterinary Medicine, University of Kerbala


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