PREPARATION AND CHARACTERIZATION OF EDIBLE OIL NANOEMULSIONS FOR ENHANCED STABILITY AND ORAL DELIVERY OF CURCUMIN

  • Jonathan Sampath Franklyne Centre for Nanobiotechnology, Vellore Institute of Technology, Vellore-632014, India.
  • Abinaya Nadarajan Centre for Nanobiotechnology, Vellore Institute of Technology, Vellore-632014, India.
  • Andrew Ebenazer Centre for Nanobiotechnology, Vellore Institute of Technology, Vellore-632014, India.
  • Nisha Tiwari Centre for Nanobiotechnology, Vellore Institute of Technology, Vellore-632014, India.
  • Amitava Mukherjee Centre for Nanobiotechnology, Vellore Institute of Technology, Vellore-632014, India.
  • Natrajan Chandrasekaran Senior Professor & Director Centre for Nanobiotechnology, Vellore Institute of Technology, Vellore-632014, India.

Abstract

Objective: This work aims to improve the oral bioavailability and long-term aqueous stability of curcumin using various edible oil nanoemulsions (NEs).

Methods: NEs were optimized using the water titration method. Curcumin was loaded into optimized emulsions, and the physicochemical characteristics were determined. Long-term stability of curcumin in the edible oil NEs was analyzed by determining the droplet size, PDI and curcumin concentrations over 4 mo. Release of curcumin from the NEs was determined using a Franz diffusion apparatus and analysed using 5 mathematical models.

Results: The absorbance of curcumin was linear over the concentration range of 1 to 10 μg. ml-1. The LOD and LOQ ranged from 0.57 to 1.26μg. ml-1 and 1.89 to 4.19μg. ml-1 respectively. All the NEs were monodisperse and had a droplet size less than 150 nm. Long-term emulsion stability shows no change in droplet size and PI (Dunnett's multiple comparisons test with a confidence interval of 95%). Olive oil NE showed significantly low release in gastric fluid (9.28%) with a good release (92.99%) in intestinal fluid and 48% in a body fluid by 8 h.

Conclusion: The work highlights the use of olive oil NEs as a delivery vehicle for curcumin with excellent release characteristics and the ability to protect curcumin in an aqueous environment.

Keywords: Edible oil nanoemulsions, Nanoemulsion, Olive oil emulsions, Curcumin delivery system, Oral bioavailability, Release kinetics

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Franklyne, J. S., Nadarajan, A., Ebenazer, A., Tiwari, N., Mukherjee, A., & Chandrasekaran, N. (2018). PREPARATION AND CHARACTERIZATION OF EDIBLE OIL NANOEMULSIONS FOR ENHANCED STABILITY AND ORAL DELIVERY OF CURCUMIN. International Journal of Applied Pharmaceutics, 10(6), 139-146. https://doi.org/10.22159/ijap.2018v10i6.28726
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