PREPARATION AND CHARACTERIZATION OF EDIBLE OIL NANOEMULSIONS FOR ENHANCED STABILITY AND ORAL DELIVERY OF CURCUMIN


Jonathan Sampath Franklyne, Abinaya Nadarajan, Andrew Ebenazer, Nisha Tiwari, Amitava Mukherjee, Natrajan Chandrasekaran

Abstract


Objective: This work aims to improve the oral bioavailability and long-term aqueous stability of curcumin using various edible oil nanoemulsions (NEs).

Methods: NEs were optimized using the water titration method. Curcumin was loaded into optimized emulsions, and the physicochemical characteristics were determined. Long-term stability of curcumin in the edible oil NEs was analyzed by determining the droplet size, PDI and curcumin concentrations over 4 mo. Release of curcumin from the NEs was determined using a Franz diffusion apparatus and analysed using 5 mathematical models.

Results: The absorbance of curcumin was linear over the concentration range of 1 to 10 μg. ml-1. The LOD and LOQ ranged from 0.57 to 1.26μg. ml-1 and 1.89 to 4.19μg. ml-1 respectively. All the NEs were monodisperse and had a droplet size less than 150 nm. Long-term emulsion stability shows no change in droplet size and PI (Dunnett's multiple comparisons test with a confidence interval of 95%). Olive oil NE showed significantly low release in gastric fluid (9.28%) with a good release (92.99%) in intestinal fluid and 48% in a body fluid by 8 h.

Conclusion: The work highlights the use of olive oil NEs as a delivery vehicle for curcumin with excellent release characteristics and the ability to protect curcumin in an aqueous environment.


Keywords


Edible oil nanoemulsions, Nanoemulsion, Olive oil emulsions, Curcumin delivery system, Oral bioavailability, Release kinetics

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About this article

Title

PREPARATION AND CHARACTERIZATION OF EDIBLE OIL NANOEMULSIONS FOR ENHANCED STABILITY AND ORAL DELIVERY OF CURCUMIN

Keywords

Edible oil nanoemulsions, Nanoemulsion, Olive oil emulsions, Curcumin delivery system, Oral bioavailability, Release kinetics

DOI

10.22159/ijap.2018v10i6.28726

Date

04-09-2018

Additional Links

Manuscript Submission

Journal

International Journal of Applied Pharmaceutics
Articles In Press [Scheduled in Nov-Dec 2018] Page: 139-146

Online ISSN

0975-7058

Authors & Affiliations

Jonathan Sampath Franklyne
Centre for Nanobiotechnology, Vellore Institute of Technology, Vellore-632014, India.
India

Abinaya Nadarajan
Centre for Nanobiotechnology, Vellore Institute of Technology, Vellore-632014, India.
India

Andrew Ebenazer
Centre for Nanobiotechnology, Vellore Institute of Technology, Vellore-632014, India.
India

Nisha Tiwari
Centre for Nanobiotechnology, Vellore Institute of Technology, Vellore-632014, India.
India

Amitava Mukherjee
Centre for Nanobiotechnology, Vellore Institute of Technology, Vellore-632014, India.
India

Natrajan Chandrasekaran
Senior Professor & Director Centre for Nanobiotechnology, Vellore Institute of Technology, Vellore-632014, India.
India


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