DESIGN, OPTIMISATION AND EVALUATION OF PIROXICAM FAST DISSOLVING TABLETS EMPLOYING STARCH TARTRATE-A NEW SUPERDISINTEGRANT
Keywords:Fast dissolving, Superdisintegrant, Starch Tartrate, Dissolution efficiency
Objective: To enhance the solubility of poorly soluble drugs by evaluating starch tartrate as a superdisintegrant in the formulation of fast dissolving tablets by employing 23 factorial design.
Methods: Starch tartrate was synthesized by gelatinization process. The physical and micromeritic properties were performed to evaluate the synthesized starch tartrate. The fast dissolving tablets of piroxicam were prepared by using starch tartrate as a superdisintegrant in different proportions by direct compression technique using 23 factorial design. The drug content, hardness, friability, disintegration time and other dissolution characteristics like percent dissolved in 5 min (PD5), dissolution efficiency in 5 min (DE5%) and first-order rate constant (K1) were used in the evaluation of prepared fast dissolving tablets.
Results: The superdisintegrant starch tartrate prepared was found to be fine, free-flowing slightly crystalline powder. Starch tartrate exhibited good swelling in water. The study between piroxicam and starch tartrate was shown the absence of interaction by fourier transform infrared spectra (FTIR) and differential scanning calorimetry (DSC). The drug content (99.83±0.56 %), hardness (3.7–3.9 kg/sq. Cm), and friability (0.12-0.15%) have been effective with regard to all the formulated fast dissolving tablets employing starch tartrate. The disintegration time of all the formulated fast dissolving tablets (FDTs) was found to be in the range of 12±0. 01 to 4500±0.02s. The optimized formulation F6 has the least disintegration time i.e., 12±0. 01s. The In vitro wetting time of the formulated tablets was found to be in the range of 35±0.09 to 1624±0.02s. The In–Vitro wetting time was less (i.e., 90s) in optimized formulation F6. The water absorption ratio of the formulated tablets was found to be in the range of 60±0.12 to 65±0.15%. The cumulative drug dissolved in the optimized formulation F6 was found to be 99.32±0.09% in 10 min.
Conclusion: The dissolution efficiency of piroxicam was enhanced when starch tartrate was found to be a superdisintegrant when combined with crospovidone and, hence it could be used in the formulation of fast dissolving tablets to provide immediate release of the contained drug within 10 min.
Anupam Roy. Orodispersible tablets: a review. Asian J Pharm 2016;9:19-26.
Nazia Khanam, Md Irshad Alam, Quazi Md Aamer Iqbal Md Yusuf Ali, Aquil-Ur-Rahman Siddiqui. A review on the optimization of drug delivery system with experimental designs. Int J Appl Pharm 2018;10:7-12.
Ashish Masih, Amar Kumar, Shivam Singh, Ajay Kumar Tiwari. Fast dissolving tablets: a review. Int J Curr Pharm Res 2017;9:8-18.
Aher Smita S, Saudagar RB, Shinde Mayuri S. Review: fast dissolving tablet. Int J Curr Pharm Res 2018;10:5-12.
Lachman L, Libermann HA, Kanig JL. The theory and practice of industrial pharmacy. 3rdedition; 1991. p. 233-5.
Prashant Bhide, Reeshwa Nachinolkar. Formulation of fast-dissolving tablets of doxazosin mesylate drug by direct compression method. Int J Appl Pharm 2017;9:22-8.
Syam Prasad Borra, M Chenna Eswaraiah, G Kamalakar Reddy. Formulation development and characterization of meclizine hydrochloride fast dissolving tablets using solid dispersion technique. Int J Appl Pharm 2018;10:141-6.
The United States Pharmacopoeia 29, National Formulary 24, Asian Edition. Rockville, MD: United States Pharmacopoeia Convention, Inc; 2006. p. 1890.
Ng Raghavendra Rao, Durga Bhavani P. Formulation and evaluation of valsartan fast disintegrating tablets by vacuum drying technique. Asian J Pharm Clin Res 2016;9:73-9.
Pratik Swarup Das, Sushma Verma, Puja Saha. Formulation development and evaluation of fast disintegrating tablets of cinitapride hydrogen tartrate by using direct compression technique. Int J Curr Pharm Res 2017;9:93-103.
Piyush Jain, RN Gupta, Sandeep Shrivastava. Formulation and evaluation of mouth dissolving tablets of omeprazole. Int J Curr Pharm Res 2016;8:48-51.
Rama Rao Tadikonda, Bhaskar Daravath. Formulation and evaluation of meclizine hydrochloride fast dissolving tablets using solid dispersion method. Asian J Pharm Clin Res 2014;7:98-102.
Shireen Begum, Syed Abdul, Azeez Basha, Shazia Fatima. Formulation and in vitro evaluation of mouth dissolving tablets of amlodipine and rosuvastatin. Int J Curr Pharm Res 2015;7:43-8.
Babji Movva, D Laxman Kumar, K Mohan Ravi Kumar. Formulation and evaluation of fast dissolving tablets of ranitidine hydrochloride by hole technology. Asian J Pharm Clin Res 2013;6:143-7.
Sachan Anupam K, Tripathi K, Visnoi G, Rasheed A, Sharma R, Gangwar SS. Formulation development and characterization of piroxicam fast dissolving tablets approved for the treatment of arthritis. Int J Drug Dev Res 2015;5:187-91.