FORMULATION OF SUSPENDING VEHICLES FOR EXTEMPORANEOUS ORAL LIQUID COMPOUNDING WITH DILTIAZEM HYDROCHLORIDE AS A DRUG MODEL

Authors

  • Sutriyo Department of Pharmacy, Universitas Indonesia, Depok, 16424, Indonesia
  • Zahra Meilia Nisa Department of Pharmacy, Universitas Indonesia, Depok, 16424, Indonesia

DOI:

https://doi.org/10.22159/ijap.2018.v10s1.51

Keywords:

Diltiazem hydrochloride, Suspending vehicle, Extemporaneous oral liquid formulation, Stability

Abstract

Objective: This study aimed to determine the optimum concentrations of a suspending vehicle and develop a physically and chemically stable
formulation containing diltiazem hydrochloride (DTZ).
Methods: Stability testing was performed for 30 days in selected suspending vehicle formulas (Formulas A and E). Physical stability tests were
performed at room temperature, and physical properties (odor and color) and pH values of suspensions were evaluated.
Results: The oral suspensions of DTZ were white and had a drug-like odor, and the pH had significantly decreased during storage. Chemical stability
tests of suspensions were performed at room temperature and 4°C±2°C using ultraviolet-visible spectrophotometry.
Conclusion: The concentrations of DTZ in oral suspensions fluctuated during the storage period, suggesting that the oral suspensions of DTZ are
physically stable but not chemically stable during storage.

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References

Garg A, Garg S, She RW. Development of an extemporaneous oral

liquid formulation of oxandrolone and its stability evaluation. Burns

;37:1150-3.

Patel VP, Desai TR, Chavda BG, Katira RM. Extemporaneous dosage

form for oral liquids. Pharmacophore 2011;2:86-103.

Wiedyaningsih C, Hakimi M, Soenarto Y, Suryawat S. The use of the

theory of planned behavior to predict factors influencing physician’s

decision to prescribe extemporaneous compounding dosage form for

pediatric outpatients. Asian J Pharma Clin Res 2016;9:288-91.

Masareddy RS, Aloknath G, Kurien D. Development and

characterization of diltiazem hydrochloride pulsatile drug delivery

system for chronomodulated therapy. Asian J Pharma Clin Res

;4:168-73.

Benzi JR, Mastroianni PD. Analysis of extemporaneous oral liquid

from commercially available drugs in hospital. Braz J Pharm Sci

;52:517-25.

Muśko M, Sznitowska M. Stability of extemporaneous pediatric

oral liquids compounded from tablets and drug substance: Case of

propranolol and theophylline. Acta Pol Pharm 2013;70:137-45.

Khrisna A, Mohanan S. Formulation and evaluation of oral liquid

suspension of paracetamol using newly isolated and characterized

Hygrophila spinosa seed mucilage as suspending agent. Asian J Pharm

Clin Res 2018;11:437-41.

Junyaprasert VB, Manwiwattanakul G. Release profile comparison

and stability of diltiazem-resin microcapsules in sustained release

suspensions. Int J Pharm 2008;352:81-91.

Nadaf SJ, Mali SS, Salunkhe SS, Kamble PM. Formulation and

evaluation of ciprofloxacin suspension using natural suspending agent.

Int J Pharm Sci Res 2014;5:63-70.

Senthil V, Sripreethi D. Formulation and evaluation of paracetamol

suspension from Trigonella foenum graecum mucilage. J Adv Pharm

Educ Res 2011;1:225-33.

Indonesian Ministry of Health. Indonesian Pharmacopeia. 4th ed.

Jakarta: Indonesian Ministry of Health; 1995.

Kuntawar RD, Mulgund SV. UV spectrophotometric estimation of

diltiazem hydrochloride in bulk and tablet dosage form. World J Pharm

Pharm Sci 2014;3:634-41.

Rahman N, Hejaz-Azmi SN. Spectrophotometric determination of

diltiazem hydrochloride with sodium metavanadate. Microchem J

;65:39-43.

Indonesian Ministry of Health. Indonesian Pharmacopeia. 5th ed.

Jakarta: Indonesian Ministry of Health; 2014.

Published

20-12-2018

How to Cite

Sutriyo, & Nisa, Z. M. (2018). FORMULATION OF SUSPENDING VEHICLES FOR EXTEMPORANEOUS ORAL LIQUID COMPOUNDING WITH DILTIAZEM HYDROCHLORIDE AS A DRUG MODEL. International Journal of Applied Pharmaceutics, 10(1), 223–234. https://doi.org/10.22159/ijap.2018.v10s1.51

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Original Article(s)