ENERGY SAVINGS ON CURCUMINE DERIVATIVE GAMAVUTON-0 SYNTHESIS USING MICROWAVE IRRADIATION

  • Sabtanti Harimurti School of Pharmacy, Faculty of Medicine and Health Sciences, Universitas Muhammadiyah Yogyakarta Jalan Brawijaya, Tamantirto, Kasihan, Bantul, Yogyakarta, Indonesia, 55183
  • Winny Setyo Nugroho Medical Education, Faculty of Medicine and Health Sciences, Universitas Muhammadiyah Yogyakarta Jalan Brawijaya, Tamantirto, Kasihan, Bantul, Yogyakarta, Indonesia, 55183
  • Ardi Pramono Medical Education, Faculty of Medicine and Health Sciences, Universitas Muhammadiyah Yogyakarta Jalan Brawijaya, Tamantirto, Kasihan, Bantul, Yogyakarta, Indonesia, 55183

Abstract

Objective: The aim of this study was to develop a more effective and environmentally friendly synthesis method for anti-cancer curcumine derivatives, namely 1,5-bis (4’-hydroxy-3’-metoxyfenyl)-1,4-pentadiene-3-one or gamavuton-0.


Methods: The experiment was conducted using two different energy sources, i.e. conventional heating and microwave irradiation. Vanillin and acetone were used as starting materials, and hydrochloric acid as the catalyst. During synthesis, variations in the synthesis period were carried out to study the effect of time on the gamavuton-0 produced. Based on experimental data, energy consumption between conventional method and microwave were evaluated.


Results: Evaluation of energy consumption was calculated based on experimental data. It was found that energy consumption for production using microwave irradiation was reduced to 0.0014 kWh/gram of crude gamavuton-0 products from 0.19 KWh/gram of crude gamavuton-0 product using conventional heating.


Conclusion: Based on calculations from experimental data, microwave irradiation during the synthesis of gamavuton-0 significantly saves energy consumption for synthesis.

Keywords: Cancer, Curcumine, Synthesis, Microwave, Energy savings

Author Biographies

Sabtanti Harimurti, School of Pharmacy, Faculty of Medicine and Health Sciences, Universitas Muhammadiyah Yogyakarta Jalan Brawijaya, Tamantirto, Kasihan, Bantul, Yogyakarta, Indonesia, 55183

School of Pharmacy, Faculty of Medicine and Health Sciences, Universitas Muhammadiyah Yogyakarta

Winny Setyo Nugroho, Medical Education, Faculty of Medicine and Health Sciences, Universitas Muhammadiyah Yogyakarta Jalan Brawijaya, Tamantirto, Kasihan, Bantul, Yogyakarta, Indonesia, 55183

Medical Education, Faculty of Medicine and Health Sciences, Universitas Muhammadiyah Yogyakarta

Ardi Pramono, Medical Education, Faculty of Medicine and Health Sciences, Universitas Muhammadiyah Yogyakarta Jalan Brawijaya, Tamantirto, Kasihan, Bantul, Yogyakarta, Indonesia, 55183

Medical Education, Faculty of Medicine and Health Sciences

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Harimurti, S., Nugroho, W. S., & Pramono, A. (2019). ENERGY SAVINGS ON CURCUMINE DERIVATIVE GAMAVUTON-0 SYNTHESIS USING MICROWAVE IRRADIATION. International Journal of Applied Pharmaceutics, 11(3), 155-158. https://doi.org/10.22159/ijap.2019v11i3.31979
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