• ANGGA WIRATAMA LOKESWARA Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia
  • KEVIN AFARATU Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia
  • RAFINDHRA ADHITYA PRIHASTAMA Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia
  • SITI FARIDA Department of Medical Pharmacy, Universitas Indonesia, Jakarta, Indonesia


Objective: Hypertension causes 7.5 million deaths annually worldwide. Antihypertensive drugs cause side effects, potentially leading to non-adherence, hence uncontrolled hypertension and increased risk of cardiovascular morbidity and mortality. Therefore, there has been increasing interest in alternative pharmacological treatments for hypertension, one of which is black cumin, or Nigella sativa, a traditional medicine that has been empirically used. This evidence-based case report aims to evaluate the current evidence for the effectiveness of Nigella sativa in reducing blood pressure in a mildly hypertensive patient.

Methods: A literature search was performed on MEDLINE, TRIP Database, Clinical Key, ScienceDirect, and DynaMed, using the keywords “nigella sativa”, “hypertension”, and “blood pressure” with all their synonyms and related terms. The included studies were two systematic reviews and two clinical trials, which were then critically appraised.

Results: Out of the four studies, three were considered valid. In terms of importance, Sahebkar et al. showed a reduction of the weighted mean difference (WMD) by Nigella sativa: −3.26 mmHg, 95% CI: −5.10, −1.42, I2 = 59% for systolic blood pressure and WMD: −2.80 mmHg, 95% CI: −4.28, −1.32, I2 = 60% for diastolic blood pressure. Badar et al. concluded that Nigella sativa significantly reduced systolic and diastolic blood pressure compared with the control group. Two studies were considered applicable to our patient in question.

Conclusion: The current evidence for the effect of Nigella sativa in lowering blood pressure is limited. However, one study gives strong evidence for significant antihypertensive effects of Nigella sativa. In mild hypertension, Nigella sativa could be one of the therapeutic options.

Keywords: Hypertension, Blood pressure, Nigella sativa, Black seed, Black cumin


1. World Health Organization. WHO Raised blood pressure.; 2018. Available from: ncd/risk_factors/blood_pressure_prevalence_text/en/. [Last accessed on 02 Oct 2018]
2. Badan Penelitian dan Pengembangan Kesehatan. Riset Kesehatan Dasar 2013. Jakarta: Kementrian Kesehatan Republik Indonesia; 2013.
3. Kementrian Kesehatan Republik Indonesia. Sebagian Besar Penderita Hipertensi tidak Menyadarinya.; 2017. Available from: 17051800002/sebagian-besar-penderita-hipertensi-tidak-menyadarinya.html. [Last accessed on 02 Oct 2018]
4. Whelton PK, Carey RM, Aronow WS, Casey DE, Collins KJ, Himmelfarb CD, et al. 2017ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA Guideline for the prevention, detection, evaluation, and management of high blood pressure in adults: a report of the American College of Cardiology/American Heart Association Task Force on clinical practice guidelines. J Am Coll Cardiol 2018;71:e127.
5. Tedla YG, Bautista LE. Drug side effect symptoms and adherence to antihypertensive medication. Am J Hypertens 2016;29:772–9.
6. Morgado M, Rolo S, Macedo AF, Pereira L, Castelo-Branco M. Predictors of uncontrolled hypertension and antihypertensive medication nonadherence. J Cardiovasc Dis Res 2010;1:196–202.
7. Gu Q, Burt VL, Paulose Ram R, Yoon S, Gillum RF. High blood pressure and cardiovascular disease mortality risk among U. S. adults: the third National Health and Nutrition Examination Survey mortality follow-up study. Ann Epidemiol 2008;18:302–9.
8. Disi SS, Anwar MA, Eid AH. Anti-hypertensive herbs and their mechanisms of action: part I. Front Pharmacol 2015;6:323.
9. Salem ML. Immunomodulatory and therapeutic properties of the Nigella sativa L. seed. Int J Immunopharmacol 2005;5:1749–70.
10. Ubru U, Burak U, Yusuf S, Reyhan B, Arif K, Faruk TH. Cardioprotective effects of Nigella sativa oil on cyclosporine a-induced cardiotoxicity in rats. Basic Clin Pharmacol Toxicol 2008;103:574–80.
11. Mathur ML, Gaur J, Sharma R, Haldiya KR. Antidiabetic properties of a spice plant Nigella sativa. J Endocrinol Metab 2011;1:1–8.
12. Nader MA, El-Agami DS, Suddek GM. Protective effects of propolis and thymoquinone on development of atherosclerosis in cholesterol-fed rabbits. Arch Pharm Res 2010;337:637–43.
13. Badar A, Kaatabi H, Bamosa A, Al-Elq A, Abou-Hozaifa B, Lebda F, et al. Effect of Nigella sativa supplementation over a one-year period on lipid levels, blood pressure and heart rate in type-2 diabetic patients receiving oral hypoglycemic agents: nonrandomized clinical trial. Ann Saudi Med 2017;37:56–63.
14. Rizka A, Setiati S, Lydia A, Dewiasty E. Effect of Nigella sativa seed extract for hypertension in elderly: a double-blind, randomized controlled trial. Acta Med Indones 2017;49:7.
15. Sahebkar A, Soranna D, Liu X, Thomopoulos C, Simental Mendia LE, Derosa G, et al. A systematic review and meta-analysis of randomized controlled trials investigating the effects of supplementation with Nigella sativa (black seed) on blood pressure. J Hypertens 2016;34:2127–35.
16. Mohtashami A, Entezari M. Effects of nigella sativa supplementation on blood parameters and anthropometric indices in adults: a systematic review on clinical trials. J Res Med Sci 2016;21:3.
17. Herlina, Aziz SA, Kurniawati A, Faridah DN. Changes of thymoquinone, thymol, and malondialdehyde content of black cumin (Nigella sativa L.) in response to Indonesia tropical altitude variation. HAYATI J Biosci 2017;24:156–61.
18. Teres S, Barcelo Coblijn G, Benet M, Alvarez R, Bressani R, Halver JE, et al. Oleic acid content is responsible for the reduction in blood pressure induced by olive oil. Proc Natl Acad Sci 2008;105:13811–6.
19. Tahir KE, Ashour MM, Al-Harbi MM. The cardiovascular actions of the volatile oil of the black seed (Nigella sativa) in rats: elucidation of the mechanism of action. Gen Pharmacol 1993;24:1123–31.
20. Tahir KE, Ageel AM. Effect of volatile oil of Nigella sativa on the arterial blood pressure and heart rate of the guinea pig. Saudi Med J 1994;2:163–8.
21. Peixoto Neves D, Silva Alves KS, Gomes MD, Lima FC, Lahlou S, Magalhaes PJ, et al. Vasorelaxant effects of the monoterpenic phenolisomers, carvacrol and thymol, on rat isolated aorta. Fundam Clin Pharmacol 2010;24:341–50.
22. Andriambeloson E, Magnier C, Haan Archipoff G, Lobstein A, Anton R, Beretz A, et al. Natural dietary polyphenolic compounds cause endothelium-dependent vasorelaxation in rat thoracic aorta. J Nutr 1998;128:2324–33.
23. Zaoui A, Cherrah Y, Lacaille Dubois MA, Settaf A, Amarouch H, Hassar M. Diuretic and hypotensive effects of Nigella sativa in the spontaneously hypertensive rat. Therapie 2000;55:379–82.
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How to Cite
LOKESWARA, A. W., AFARATU, K., PRIHASTAMA, R. A., & FARIDA, S. (2019). ANTIHYPERTENSIVE EFFECTS OF NIGELLA SATIVA: WEIGHING THE EVIDENCE. International Journal of Applied Pharmaceutics, 11(6), 135-139.
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