ALOE VERA VS. SILVER SULFADIAZINE FOR TREATING SECOND-DEGREE BURN WOUNDS: EVIDENCE-BASED CASE REPORT

  • CLARA MENNA Undergraduate Program, Faculty of Medicine, Universitas Indonesia, Jakarta,
  • NABILLA CALISTA Undergraduate Program, Faculty of Medicine, Universitas Indonesia, Jakarta,
  • LEORCA AURINO Undergraduate Program, Faculty of Medicine, Universitas Indonesia, Jakarta
  • ADISTI DWIJAYANTI Department of Medical Pharmacy, Faculty of Medicine, Universitas Indonesia, Jakarta

Abstract

Objective: Current treatment for second-degree burn wounds, including silver sulfadiazine (SSD) application, may cause side effects such as delayed and incomplete wound healing, leaving a scar. Traditional plants empirically used for burn wounds, such as Aloe vera, seem to be a promising option with good safety profiles.


Methods: We therefore compared Aloe vera to SSD for second-degree burn wounds based on a review of clinical trials obtained by an organized search through the Cochrane, PubMed, and DynaMed databases. Three randomized clinical trials studies were selected, two of which were critically appraised. The third study, with a different outcome assessment, was analyzed separately.


Results: Two studies showed that Aloe vera was more effective in treating second-degree burn wounds than SSD 1% with an absolute risk reduction of 0.2, relative risk reduction of 0.83–1.0, and number needed to treat five patients. The Aloe vera group showed faster healing, earlier epithelialization, and earlier pain alleviation. The third study combined Aloe vera with other herbs, which showed better healing ability and restored skin hydration than those with SSD.


Conclusion: Each of the three articles stated that Aloe vera was more effective than SSD for treating second-degree burn wounds. Nevertheless, each of the studies lacked methodology and comprehensive data reporting.

Keywords: Aloe vera, Second-degree burn wounds, Silver sulfadiazine

References

1. Radha MH, Laxmipriya NP. Evaluation of biological properties and clinical effectiveness of Aloe vera: a systematic review. J Tradit Complement Med 2014;5:21–6.
2. Manvitha K, Bidya B. Aloe vera: a wonder plant: its history, cultivation and medicinal uses. J Pharmacogn Phytochem 2014;2:85–8.
3. Rajeswari R, Umadevi M, Sharmila Rahale C, Pushpa R, Selvavenkadesh S, Sampath Kumar KP, et al. Aloe vera: the miracle plant: its medicinal and traditional uses in India. J Pharmacogn Phytochem 2012;1:118–24.
4. Sahu PK, Giri DD, Singh R, Pandey P, Gupta S, Shrivastava AK, et al. Therapeutic and medicinal uses of aloe vera: a review. Pharmacol Pharm 2013;4:599–610.
5. Mitra R, Mitchell B, Gray C, Orbell J, Coulepis T, Muralitharan M. Medicinal plants of Indonesia. Asia Biotech 2007;11:726–8.
6. Christaki E, Florou Paneri P. Aloe vera: a plant for many uses. J Food Agric Environ 2010;8:245–9.
7. Akhoondinasab MR, Akhoondinasab M, Saberi M. Comparison of healing effect of aloe vera extract and silver sulfadiazine in burn injuries in experimental rat model. World J Plast Surg 2014;3:29–34.
8. Schmidt JM, Greenspoon JS. Aloe vera dermal wound gel is associated with a delay in wound healing. Obstet Gynecol 1991;78:115–7.
9. Hermans MH. Results of an internet survey on the treatment of partial thickness burns, full thickness burns, and donor sites. J Burn Care Res 2007;28:835-47.
10. Wardhana A. [Practical guidelines in Burn Wound Management.] (Indonesian) 1st ed. Jakarta: Lingkar Studi Bedah Plastik Foundation; 2014.
11. Shahzad MN, Ahmed N. Effectiveness of aloe vera gel compared with 1% silver sulphadiazine cream as burn wound dressing in second-degree burns. J Pak Med Assoc 2013;63:225-30.
12. Critical appraisal tools. CEBM; 2005. Available from: https://www.cebm.net/2014/06/critical-appraisal/ [Last accessed on 10 Oct 2018]
13. Khorasani G, Hosseinimehr S, Azadbakht M, Zamani A, Mahdavi MR. Aloe versus silver sulfadiazine creams for second-degree burns: a randomized controlled study. Surg Today 2009;39:587-91.
14. Panahi Y, Beiraghdar F, Akbari H, Bekhradi H, Taghizadeh M, Sahebkar A. A herbal cream consisting of Aloe vera, Lavandula stoechas, and Pelargonium roseum as an alternative for silver sulfadiazine in burn management. Asian Biomed 2012;6:273-8.
15. Dat AD, Poon F, Pham KBT, Doust J. Aloe vera for treating acute and chronic wounds. Cochrane Database Syst Rev 2010;CD00876.
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MENNA, C., CALISTA, N., AURINO, L., & DWIJAYANTI, A. (2019). ALOE VERA VS. SILVER SULFADIAZINE FOR TREATING SECOND-DEGREE BURN WOUNDS: EVIDENCE-BASED CASE REPORT. International Journal of Applied Pharmaceutics, 11(6). Retrieved from https://innovareacademics.in/journals/index.php/ijap/article/view/33580
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