DEVELOPMENT OF NOVEL MICROSTRUCTURED LIPID CARRIERS FOR DISSOLUTION RATE ENHANCEMENT OF ALBENDAZOLE

  • CASTRO ALPIZAR J. A. Faculty of Pharmacy, University of Costa Rica, San Jose, Costa Rica
  • PACHECO MOLINA J. Laboratory of Pharmaceutical Technology, Faculty of Pharmacy, University of Costa Rica, San Jose, Costa Rica
  • VARGAS MONGE R. Laboratory of Pharmaceutical Technology, Faculty of Pharmacy, University of Costa Rica, San Jose, Costa Rica
  • MADRIGAL REDONDO G. Laboratory of Biopharmacy and Pharmacokinetics (LABIOFAR), Institute of Pharmaceutical Research (INIFAR), Faculty of Pharmacy, University of Costa Rica, San José, Costa Rica https://orcid.org/0000-0002-9856-4044

Abstract

Objective: This study aimed to develop a microstructured lipid carrier that improves the rate of dissolution of the active pharmaceutical ingredient (API) Albendazole.


Methods: A solvent diffusion method was used for the development of microstructured lipid carriers. The developed carriers were characterized by optical microscopy, infrared spectroscopy, differential scanning calorimetry (DSC), X-ray diffractometry (XRD), and dissolution testing.


Results: The morphology of the carriers was irregular, and their size tends to decrease with the addition of modifiers. Furthermore, the diffractograms and the thermograms indicated a loss of crystallinity. The thermograms and infrared spectra showed that there are not chemical incompatibilities between the API and the excipients. When the lipid carrier particles were modified with Aerosil® 200 (specifically when using this excipient at a level of 6% w/w), dissolution was increased up to 85.96±1.17 % of the drug content as per USP test for Albendazole tablets in comparison with 36.13±0.52 % for a lipid carrier formulation without modifiers.


Conclusion: It was demonstrated that it is possible to develop a modified lipid carrier that improves the dissolution rate of an API with a low solubility, which was related to the amorphization of the API crystalline structure.

Keywords: Albendazole, Microstructured lipid carrier, Dissolution, Crystalline structure

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J. A., C. A., J., P. M., R., V. M., & G., M. R. (2020). DEVELOPMENT OF NOVEL MICROSTRUCTURED LIPID CARRIERS FOR DISSOLUTION RATE ENHANCEMENT OF ALBENDAZOLE. International Journal of Applied Pharmaceutics, 12(6), 173-178. https://doi.org/10.22159/ijap.2020v12i6.34782
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