CO-CRYSTALS OF CARVEDILOL: PREPARATION, CHARACTERIZATION AND EVALUATION: CO-CRYSTALS OF CARVEDILOL

RAJU THENGE; RAKESH  PATEL; NANDU  KAYANDE; NILESH MAHAJAN

doi:10.22159/ijap.2020v12i1.35640

Authors

RAJU THENGE School of Pharmacy, Dr. A. P. J. Abdul Kalam University, Indore (M. P), India
RAKESH PATEL School of Pharmacy, Dr. A. P. J. Abdul Kalam University, Indore (M. P), India
NANDU KAYANDE Thakur Shiv Kumar Singh Memorial Pharmacy College, Burhanpur, (M. P), India.
NILESH MAHAJAN Dadasaheb Balpande College of Pharmacy, Besa-Nagpur, Maharashtra, India

DOI:

https://doi.org/10.22159/ijap.2020v12i1.35640

Keywords:

Carvedilol, Co-crystals, Solubility, FT-IR, Dissolution rate, Micromeritic properties

Abstract

Carvedilol an antihypertensive drug, exhibit poor solubility and dissolution rate. Hence an attempt has been made to prepare the Co-crystals of Carvedilol to increase the solubility and dissolution rate by solvent evaporation method using coformer such as succinic acid, fumaric acid and oxalic acid. The prepared Co-crystals were evaluated for solubility, dissolution rate and micromeritic properties. The Co-crystals were characterized by scanning electronic Microscopy (SEM), FT-Infrared Spectroscopy (FTIR), Differential Scanning Calorimetry (DSC) and X-ray Diffractometry (XRD). The CAR-SA Co-crystal, CAR-FA Co-crystals and CAR-OA Co-crystals showed increased in solubility and dissolution rate compared to pure Carvedilol. The Co-crystals formed with coformer have showed improved micromeritic properties. SEM clearly showed the formation of new solid phase with the coformer. The FT-IR spectra indicate the shifting of characteristic peak in the Co-crystals but does not showed any interaction between the coformer used. DSC data showed the change in the endotherm with the melting points of Co-crystals. XRD spectra indicate the notified difference in the 2θ and the intensity of the peaks. Hence the Co-crystal formation could be helpful to improve the solubility, dissolution and micromeritic properties of Carvedilol.

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Author Biographies

NANDU KAYANDE, Thakur Shiv Kumar Singh Memorial Pharmacy College, Burhanpur, (M. P), India.

Principal

NILESH MAHAJAN, Dadasaheb Balpande College of Pharmacy, Besa-Nagpur, Maharashtra, India

Professor

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