• RAJU THENGE School of Pharmacy, Dr. A. P. J. Abdul Kalam University, Indore (M. P), India
  • RAKESH PATEL School of Pharmacy, Dr. A. P. J. Abdul Kalam University, Indore (M. P), India
  • NANDU KAYANDE Thakur Shiv Kumar Singh Memorial Pharmacy College, Burhanpur, (M. P), India.
  • NILESH MAHAJAN Dadasaheb Balpande College of Pharmacy, Besa-Nagpur, Maharashtra, India


Carvedilol an antihypertensive drug, exhibit poor solubility and dissolution rate. Hence an attempt has been made to prepare the Co-crystals of Carvedilol to increase the solubility and dissolution rate by solvent evaporation method using coformer such as succinic acid, fumaric acid and oxalic acid. The prepared Co-crystals were evaluated for  solubility, dissolution rate and micromeritic properties. The Co-crystals were characterized by scanning electronic Microscopy (SEM), FT-Infrared Spectroscopy (FTIR), Differential Scanning Calorimetry (DSC) and X-ray Diffractometry (XRD). The CAR-SA Co-crystal, CAR-FA Co-crystals and CAR-OA Co-crystals showed increased in solubility and dissolution rate compared to pure Carvedilol. The Co-crystals formed with coformer have showed improved micromeritic properties. SEM clearly showed the formation of new solid phase with the coformer. The FT-IR spectra indicate the shifting of characteristic peak in the Co-crystals but does not showed any interaction between the coformer used. DSC data showed the change in the endotherm with the melting points of Co-crystals. XRD spectra indicate the notified difference in the 2θ and the intensity of the peaks. Hence the Co-crystal formation could be helpful to improve the solubility, dissolution and micromeritic properties of Carvedilol.

Keywords: Carvedilol, Co-crystals, Solubility, FT-IR, Dissolution rate, Micromeritic properties.

Author Biographies

NANDU KAYANDE, Thakur Shiv Kumar Singh Memorial Pharmacy College, Burhanpur, (M. P), India.


NILESH MAHAJAN, Dadasaheb Balpande College of Pharmacy, Besa-Nagpur, Maharashtra, India



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How to Cite
THENGE, R., PATEL, R., KAYANDE, N., & MAHAJAN, N. (2019). CO-CRYSTALS OF CARVEDILOL: PREPARATION, CHARACTERIZATION AND EVALUATION. International Journal of Applied Pharmaceutics, 12(1), 42-49.
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