CO-CRYSTALS OF CARVEDILOL: PREPARATION, CHARACTERIZATION AND EVALUATION
CO-CRYSTALS OF CARVEDILOL
Carvedilol an antihypertensive drug, exhibit poor solubility and dissolution rate. Hence an attempt has been made to prepare the Co-crystals of Carvedilol to increase the solubility and dissolution rate by solvent evaporation method using coformer such as succinic acid, fumaric acid and oxalic acid. The prepared Co-crystals were evaluated for solubility, dissolution rate and micromeritic properties. The Co-crystals were characterized by scanning electronic Microscopy (SEM), FT-Infrared Spectroscopy (FTIR), Differential Scanning Calorimetry (DSC) and X-ray Diffractometry (XRD). The CAR-SA Co-crystal, CAR-FA Co-crystals and CAR-OA Co-crystals showed increased in solubility and dissolution rate compared to pure Carvedilol. The Co-crystals formed with coformer have showed improved micromeritic properties. SEM clearly showed the formation of new solid phase with the coformer. The FT-IR spectra indicate the shifting of characteristic peak in the Co-crystals but does not showed any interaction between the coformer used. DSC data showed the change in the endotherm with the melting points of Co-crystals. XRD spectra indicate the notified difference in the 2θ and the intensity of the peaks. Hence the Co-crystal formation could be helpful to improve the solubility, dissolution and micromeritic properties of Carvedilol.
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