ZIPRASIDONE HYDROCHLORIDE LOADED NANOSTRUCTURED LIPID CARRIERS (NLCS) FOR INTRANASAL DELIVERY: OPTIMIZATION AND IN VIVO STUDIES

  • PRAVEEN SIVADASU Department of Pharmaceutics, JSS College of Pharmacy, JSSAHER, Mysuru 570015, India
  • GOWDA D. V. Department of Pharmaceutics, JSS College of Pharmacy, JSSAHER, Mysuru 570015, India
  • SIDDARAMAIAH H. Department of Polymer Science and Technology, Sri Jayachamarajendra College of Engineering, Mysuru 570006, India
  • HEMALATHA S. Department of Anaesthesiology, JSS Medical College, JSSAHER, Mysuru 570015, India

Abstract

Objective: The present study was an attempt to systemically deliver the most desirable schizophrenia drug, ziprasidone hydrochloride (ZRS) via the intranasal route using nanostructured lipid carrier (NLC) approach.


Methods: The desired ZRS loaded NLCs were developed using central composite statistical design and the developed formulation was monitored for improving ZRS bioavailability and their brain targeting efficacy.


Results: Pharmacokinetic studies revealed a 10 fold increase (ZRS blood-brain ratio) for NLCs administered through nasal route (in comparison to intravenous route). Similarly, the concentration of ZRS (in the brain) delivered via nasal route exhibits 4 fold increment at all-time points.


Conclusion: Therefore, the obtained results suggest a potential nose to brain transport of loaded ZRS by effective bypassing of the Blood-Brain Barrier (BBB).

Keywords: Ziprasidone hydrochloride, Nanostructured lipid carriers, Blood/Brain barrier, Intranasal delivery

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SIVADASU, P., D. V., G., H., S., & S., H. (2019). ZIPRASIDONE HYDROCHLORIDE LOADED NANOSTRUCTURED LIPID CARRIERS (NLCS) FOR INTRANASAL DELIVERY: OPTIMIZATION AND IN VIVO STUDIES. International Journal of Applied Pharmaceutics, 12(1), 31-41. https://doi.org/10.22159/ijap.2020v12i1.35683
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