THE ANTI-INFLAMMATORY ACTIVITY OF ESSENTIAL OIL OF CLOVE (Syzygium aromaticum) IN ABSORPTION BASE OINTMENT WITH ADDITION OF OLEIC ACID AND PROPYLENE GLYCOL AS ENHANCER

  • NINING SUGIHARTINI Department of Pharmaceutical Technology, Faculty of Pharmacy at Ahmad Dahlan University, Yogyakarta, Indonesia.
  • RANI PRABANDARI Department of Pharmaceutical Technology, Faculty of Health at Harapan Bangsa University, Purwokerto, Indonesia.
  • TEDJO YUWONO Department of Pharmaceutical Technology, Faculty of Pharmacy at Ahmad Dahlan University, Yogyakarta, Indonesia.
  • DESTY RESTIA RAHMAWATI Undergraduate Program Study of Pharmacy, Faculty of Pharmacy at Ahmad Dahlan University, Yogyakarta, Indonesia.

Abstract

Background : The optimal concentration of essential oil of clove in absorption base ointment as anti-inflammatory has been studied. The development
of formulations can be done by adding oleic acid and propylene glycol as enhancers. The purpose of this study was to determine the anti-inflammatory
activity of the essential oil of clove in absorption base ointment formula by adding a mixture of oleic acid and propylene glycol as enhancers.
Methods: In this study, the composition of oleic acid and propylene glycol was 100% oleic acid (FI), 50% oleic acid and propylene glycol (FII), and
100% propylene glycol (FIII). The profile of the anti-inflammatory activity essential oil of clove was carried out using male of mice Balb/C strain which
was induced inflammatory with croton oil on back of skin. After treatment, it was sacrificed and then was taken the back of skin to get histopathological
preparation. After that, the epidermal thickness, number of inflammatory cells, and cyclooxygenase (COX)-2 expression can be measured.
Results : Based on the results of the test, it shows that FIII has the smallest of the amount of COX-2 expression, the number of inflammatory cells, and
the epidermal thickness so the addition of the composition enhancer provides good anti-inflammatory activity.
Conclusion: The increasing concentration of propylene glycol caused the raising activity of essential oil of clove as anti-inflammatory.

Keywords: Absorption base, Anti-inflammatory, Enhancer, Essential oil of clove

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SUGIHARTINI, N., PRABANDARI, R., YUWONO, T., & RAHMAWATI, D. R. (2019). THE ANTI-INFLAMMATORY ACTIVITY OF ESSENTIAL OIL OF CLOVE (Syzygium aromaticum) IN ABSORPTION BASE OINTMENT WITH ADDITION OF OLEIC ACID AND PROPYLENE GLYCOL AS ENHANCER. International Journal of Applied Pharmaceutics, 11(5), 106-109. https://doi.org/10.22159/ijap.2019.v11s5.T0081
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