• DYAH SAPTARINI Department of Nutrition, Faculty of Medicine, Universitas Indonesia Cipto Mangunkusumo Hospital, Jakarta, Indonesia
  • FIASTUTI WITJAKSONO Department of Nutrition, Faculty of Medicine, Universitas Indonesia Cipto Mangunkusumo Hospital, Jakarta, Indonesia
  • IRMA BERNADETTE S. SITOHANG Department of Dermatology and Venereology Faculty of Medicine, Universitas Indonesia Cipto Mangunkusumo Hospital, Jakarta, Indonesia


Objective: Approximately 9.4% of the world population is affected by acne during adolescence. Several previous studies have shown a significant relationship between acne vulgaris (AV) and serum vitamin D levels. The purpose of this study was to determine the correlation between AV and serum vitamin D levels in adolescents.

Methods: This cross-sectional study included 60 healthy students with AV aged 15-18 y from three high schools in Depok, which were selected via simple random selection, and the selection of participants was based on consecutive sampling selection after screening with the inclusion criteria. Serum vitamin D levels were evaluated using a direct Chemiluminescence immunoassay (CLIA) method. The lesions of AV were counted by a dermatologist. Dietary vitamin D and fat intake were assessed using a semiquantitative Food Frequency Questionnaire and 24-hour dietary recall. The data were processed using SPSS Statistics 20.0 and analyzed using Pearson or Spearman correlation tests.

Results: The mean serum vitamin D level was 17.29±6.77 ng/ml. The mean number of non-inflammatory lesions was 20.5±12.08, and the median number of inflammatory lesions was 6 (range 0-28). The correlation between the number of non-inflammatory lesion and serum vitamin D levels was r = 0.25 (p = 0.052) and the correlation between the number of inflammatory lesions and serum vitamin D levels was r = 0.047 (p = 0.72).

Conclusion: Serum vitamin D levels are not significantly correlated with AV despite whether the lesions are inflammatory or non-inflammatory.

Keywords: Adolescent, Acne vulgaris, Serum vitamin D levels


1. Tahir CM. Pathogenesis of acne vulgaris: simplified. J Pakistan Assoc Dermatol 2010;20:93-7.
2. Ghodsi SZ, Orawa H ZC. Prevalence, severity, and severity risk factors of acne in high school pupils: a community-based study. J Invest Dermatol 2009;129:2136-41.
3. Nair R, Maseeh A. Vitamin D: the sunshine vitamin. J Pharmacol Pharmacother 2012;3:118-26.
4. Nimitphong HHM. Vitamin D status and sun exposure in Southeast Asia. Dermatoendocrinol 2013;1:34–7.
5. Quah SW, Majid HA, Al-Sadat N, Yahya A, Su TT, Jalaludin MY. Risk factors of Vitamin D deficiency among 15 y old adolescents participating in the Malaysian health and adolescents longitudinal research team study (MyHeARTs). PLoS One 2018;13:e200736.
6. Lim SK, Ha JM, Lee YH. Comparison of vitamin D levels in patients with and without acne: a case-control study combined with a randomized controlled trial. PLoS One 2016;11:e016.
7. Al-Taiar A, Alkhabbaz M, Rahman A, Al-Sabah R, Shaban L, Akhtar S. Plasma 25-hydroxy vitamin D is not associated with acne vulgaris. Nutrients 2018;10:1-9.
8. Yildizgören MT, Togral AK. Preliminary evidence for vitamin D deficiency in nodulocystic acne. Dermatoendocrinol 2014;6:e983687.
9. Toossi P, Azizian Z, Yavari H, Fakhim TH, Amini SHS, Enamzade R. Serum 25-hydroxy vitamin D levels in patients with acne vulgaris and its association with disease severity. Clin Cases Miner Bone Metab 2015;12:238-42.
10. Misra M, Pacaud D, Petryk A, Collett Solberg PF, Kappy M. Vitamin d deficiency in children and its management: a review of current knowledge and recommendations. Pediatrics 2008;122:398-417.
11. Bagatin E, Timpano DL, Guadanhim LR dos S. Acne vulgaris: prevalence and clinical forms in adolescents from sao paulo, Brazil. An Bras Dermatol 2014;89:428–35.
12. Yahya H. Acne vulgaris in nigerian adolescents-prevalence, severity, beliefs, perceptions, and practices. Int J Dermatol 2009;48:498-505.
13. Jain RB. Variability in the levels of vitamin d by age, gender, and race/ethnicity: data from National Health and Nutrition Examination Survey 2007-2010. J Nutr Heal Sci 2016;3:203.
14. Neupane S, Basnet B ST. Association between acne and body mass index: a hospital-based cross-sectional study. Nepal J Dermatol Venerol Leprol 2018;16:53-6.
15. Indonesia U, Manik TJ. Korelasi antara kadar vitamin d dengan fungsi kognitif pada siswa sma di depok, jawa barat tesis; 2018.
16. Stagi S, Bertini F, Cavalli L, Matucci Cerinic M, Brandi ML, Falcini F. Determinants of vitamin D levels in children, adolescents, and young adults with juvenile idiopathic arthritis. J Rheumatol 2014;41:1884.
17. Lang PO, Aspinall R. Can we translate vitamin D immunomodulating effect on innate and adaptive immunity to vaccine response? Nutrients 2015;7:2044-60.
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SAPTARINI, D., WITJAKSONO, F., & SITOHANG, I. B. S. (2020). CORRELATION STUDY OF ACNE VULGARIS AND SERUM VITAMIN D LEVELS IN ADOLESCENTS. International Journal of Applied Pharmaceutics, 12(3). Retrieved from
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