• dr.siraj nawaj shaikh Ali Allana college of pharmacy Akkaklkuwa



Keywords: Keywords:Software Assisted, Bisoprolol Fumarate, Carbapol 940 P, Floating, Direct compression, Floating lag time, Characterization.

Author Biography

dr.siraj nawaj shaikh, Ali Allana college of pharmacy Akkaklkuwa

Dept.Pharmaceutics HOD


1. Prinderre, P., Sauzet, C. and Fuxen, C.. Advances in gastro retentive drug-delivery systems. Expert Opin. Drug Dev, 2011, 8(9), 1189-1203.
2. Sathiyaraj S, Ramya DD, Vedha BNH. Lornoxicam gastro retentive floating matrix
tablets: Design and in vitro evaluation. J Adv Pharm Technol Res. 2011;2(3):156-1623. 3.Hoffman, A., Stepensky, D., Lavy, E., Eyal, S., Klausner, E. and Friedman, M.,
Pharmacokinetic and pharmacodynamic aspects of gastroretentive dosage forms. Int.J. Pharm., 2004. 277(1-2),141-153.
4. Padmavathy J, Saravanan D, Rajesh D. Formulation and evaluation of ofloxacin
floating tablets using HPMC. Int J Pharm Pharma Sci. 2011;3(1):170-173.
5.Tort S, Han D, Steckl AJ. Self-Inflating Floating Nanofiber Membranes for Controlled Drug Delivery. Int J. Pharma. 2020 ; 17:119164.
6. Arora, S., Ali, J., Ahuja, A., Khar, R.K., Baboota, S.,. Floating drug delivery system: a
review. AAPS Pharm. Sci. Tech, 2005, 6, 372–390.
7. Davis, S.S., Stockwel, A.F., Taylor, M.J., Hardy, J.G., Whalley, D.R.,Wilson, C.G.,. The
effect of density on the gastric emptying of single and multiple unit dosage forms. Pharm. Res, 1986, 3, 208–213.
8. Patel DM, Patel NM, Pandya NM, Jogani PD. Formulation and optimization of
carbamazepine floating tablets. Indian J Pharm Sci. 2007;69(6):763-7.
9. Auriemma, G., Cerciello, A., Sansone, F., Pinto, A., Morello, S. and Aquino, R.P., Polysaccharides based gastroretentive system to sustain piroxicam release: Development and in vivo prolonged anti-inflammatory effect.Int.J.Bio.Macro, 2018, 120,2303-2312.
10. Gökbulut E, Vural ?, A??ko?lu M, Özdemir N. Floating drug delivery system of itraconazole: Formulation, in vitro and in vivo studies. J. Drug Dev.Sci.Tech,. 2019, 1;49:491-501.
11. Baumgartner, S., Kristl, J., Vrecer, F., Vodopivec, P., Zorko, B., Optimization of floating matrix tablets and evaluation of their gastric residence time. Int. J. Pharm. 2000,195, 125–135.
12. Li, S., Lin, S., Daggy, B.P., Mirchandani, H.L. and Chien, Y.W. Effect of HPMC and
carbopol on the release and floating properties of gastric floating drug delivery system using factorial design. Int.J. Pharm. 2003 , 253(1-2), 13-22.
13. Chueh, H.R., Zia, H., Rhodes, C.T. Optimization of sotalol floating and bioadhesive
extended release tablet formulation. Drug Dev. Ind. Pharm. 1995 21,1725–1747.
14. Sathiyaraj S, Ramya DD, Vedha BNH. Lornoxicam gastro retentive floating matrix
tablets: Design and in vitro evaluation. J Adv Pharm Technol Res. 2011;2(3):156-162.
15. Patil, H., Tiwari, R.V. and Repka, M.A., Recent advancements in mucoadhesive floating drug delivery systems: A mini-review. J. Drug Dev.Sci.Tech , 2016 ;31:65-71
16. Biswas, N. and Sahoo, R.K. Tapioca starch blended alginate mucoadhesive-floating beads for intragastric delivery of Metoprolol Tartrate.Int.J.Bio.Macro, 2016; 83:61-70.
17. Jagdale, S.C., Bari, N.A., Kuchekar, B.S. and Chabukswar, A.R., Optimization studies on compression coated floating-pulsatile drug delivery of bisoprolol. BioMed research Int, 2013:1-23.
18. Mahmoud, D.B., Shukr, M.H. and ElMeshad, A.N., Gastroretentive Cosolvent-Based In Situ Gel as a Promising Approach for Simultaneous Extended Delivery and Enhanced Bioavailability of Mitiglinide Calcium. J. Pharm. Sci. 2018;78(4):927-939
19. Klausner, E.A., Lavy, E., Friedman, M. and Hoffman, A., Expandable gastroretentive
dosage forms. J. Control Release, 2003, 90(2),143-162.
20. Chaturvedi K, Umadevi S, Vaghani S. Floating Matrix Dosage Form for Propranolol
Hydrochloride Based on Gas Formation Technique: Development and In Vitro
Evaluation. Sci Pharm. 2010;78(4):927-939
.21. Rosa M, Zia H, Rhodes T. Dosing and testing in vitro of a bioadhesive and floating
drug delivery system for oral application. Int J Pharm. 1994;105:65-70.
22. Dasharath MP, Mehul JP, Ankit NP, Chhagan NP. Formulation and evaluation of
mixed matrix gastro-retentive drug delivery for famotidine. Int J Pharm Investig.2011;1(4):247-254.
23. Kim, S., Hwang, K.M., Park, Y.S., Nguyen, T.T. and Park, E.S., Preparation and evaluation of non-effervescent gastroretentive tablets containing pregabalin for once-daily administration and dose proportional pharmacokinetics. Int.J. Pharm. 2018, 550(1-2),160-169.
24. Raza, A., Bukhari, N.I., Karim, S., Hafiz, M.A. and Hayat, U. Floating tablets of
minocycline hydrochloride: Formulation, in-vitro evaluation and optimization. Future J. Pharm. Sci. 2017 , 3(2),131-139.
25. Gambhire, M.N., Ambade, K.W., Kurmi, S.D., Kadam, V.J. and Jadhav, K.R.,. Development and in vitro evaluation of an oral floating matrix tablet formulation of diltiazem hydrochloride. AAPS PharmSciTech, 2007 8(3), E166-E174.
26. Bertram, U. and Bodmeier, R.,. In situ gelling, bioadhesive nasal inserts for extended drug delivery: in vitro characterization of a new nasal dosage form. European J. Pharm. Sci 2006, 27(1),62-71 capsules. US Patent No. US, 4126672.
27. Thakar, K., Joshi, G. and Sawant, K.K., Bioavailability enhancement of baclofen by
gastroretentive floating formulation: statistical optimization, in vitro and in vivo
pharmacokinetic studies. Drug. Dev. Ind. Pharm, 2013, 39(6),880-888.
28. Hwang, S.J., Park, H., Park, K., Gastric retentive drug-delivery system. Crit. Rev. Ther
Drug Carrier Syst, 1998, 15, 243–284.
29. Leung, S.H.S. and Robinson, J.R., The contribution of anionic polymer structural features to mucoadhesion. J. Control Release, 1987, 5(3),223-231.
30. Nayak, A.K., Das, B. and Maji, R., Gastroretentive hydrodynamically balanced systems of ofloxacin: In vitro evaluation. Saudi Pharm. J, 2013, 21(1),113-117.
31. Deshpande, A.A., Shah, N.H., Rhodes, C.T., Malick, W. Development of a novel controlled-release system for gastric retention. Pharm. Res, 1997, 14, 815–819.
32. Khan, G.M. and Zhu, J.B. Studies on drug release kinetics from ibuprofen–carbomer
hydrophilic matrix tablets: influence of co-excipients on release rate of the drug. J. Control Release, 1999, 57(2),97-203.
33. Cvijic, S., Ibric, S., Parojcic, J. and Djuris, J. An in vitro-in silico approach for the
formulation and characterization of ranitidine gastroretentive delivery systems. J. Drug Dev.Sci.Tech, 2018, 45,1-10.
34. Santus G, Lazzarini G, Bottoni G. An in vitro-in vivo investigation of oral bioadhesive
controlled release furosemide formulations. Eur J Pharm Biopharm. 1997;44:39-52.
35. Pawar, V.K., Kansal, S., Asthana, S. and Chourasia, M.K. Industrial perspective of
gastroretentive drug delivery systems: physicochemical, biopharmaceutical, technological
and regulatory consideration. Expert Opin. Drug Deliv, 2012, 9(5),551-565.
36. Veerareddy PR, Bajjuri S, Sanka K, Jukanti R, Bandari S, Ajmeru RK, et al.
Formulation and evaluation of gastroretentive dosage form of ofloxacin. S J Pharm
Sci. 2011;4(1):9-18.
37. Menon A, Ritshel WA, Sakr A. Developement and evaluation of a monolithic floating
dosage form for furosemide. J Pharm Sci. 1994;83:239-45
38. Singh, B., Chakkal, S.K. and Ahuja, N. Formulation and optimization of controlled
release mucoadhesive tablets of atenolol using response surface methodology. AAPS
PharmSciTech, 2006. 7(1), E19-E28
39. Vemula, S.K., Venisetty, R.K. and Veerareddy, P.R.,. Valsartan floating bioadhesive
compression-coated mini-tablets: Formulation and Pharmacokinetics. J. Drug Dev.Sci.Tech, 2017, 40,66-72.
40.Patil P, Rao BS, Kulkarni SV, Basavaraj CS, Ammanage A. Formulation and in vitro
evaluation of floating matrix tablets of ofloxacin. Asian J Res Pharm Sci. 2011;1(1):17-
.41. Singh, B.M., Kim, K.H. Floating drug delivery system: an approach to oral controlled
drug delivery via gastric retention. J. Controlled Release, 2000. 63, 235–259
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