MASTIC-G-POLY (ACRYLAMIDE): MICROWAVE-ASSISTED SYNTHESIS AND CHARACTERISATION

Authors

  • MOHIT KUMAR School of Pharmaceutical Sciences, Lovely Professional University Phagwara, Jalandhar, Punjab, India
  • SURAJPAL School of Pharmaceutical Sciences, Lovely Professional University Phagwara, Jalandhar, Punjab, India

DOI:

https://doi.org/10.22159/ijap.2021v13i2.40551

Keywords:

Mastic Gum, Microwave-assisted grafting, Acrylamide, Box Behnken design

Abstract

Objective: The objective of the present investigation was the synthesis of grafted co-polymer gum mastic using acrylamide as the monomer.

Methods: 3-factor 3-level response surface Box-Behnken design, which requires 15 runs including three replicates of the central run, was used for the synthesis of graft copolymers of mastic gum with acrylamide using ceric ammonium nitrate as the free radical initiator. The critical synthesis and process parameters; CSPP (A = concentration of monomer, B = concentration of initiator and C= Temperature) to generate design space and optimize formulation with an aim to obtain critical quality attributes (CQA, Y1 =% Yield, Y2 =% Grafting, Y3 =% grafting efficiency).

Result: Formulation F14 having a maximum % yield of 75.89% with % grafting of 210% and % grafting efficiency 51.57% was selected as best.

Conclusion: The microwave-assisted grafted mastic gum was prepared successfully and optimized by using Box Behnken design.

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Published

2021-03-07

How to Cite

KUMAR, M., & SURAJPAL. (2021). MASTIC-G-POLY (ACRYLAMIDE): MICROWAVE-ASSISTED SYNTHESIS AND CHARACTERISATION. International Journal of Applied Pharmaceutics, 13(2), 228-234. https://doi.org/10.22159/ijap.2021v13i2.40551

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Original Article(s)