FUNDAMENTAL ASPECTS OF A THIRD COMPONENT USED IN TERNARY SOLID DISPERSION: A REVIEW
Ternary solid dispersion (TSD) is one of the promising approaches used in recent studies, to address the issues encountered by the poorly water-soluble drugs. The binary solid dispersion (BSD) with the drug and the single polymer is inadequate to satisfy all the criteria such as improved solubility, dissolution, stability, supersaturation and recrystallization inhibition. Hence, the ternary solid dispersion with the third component/ternary agent aids in overcoming the limitations, thereby enhancing the solubility and bioavailability to a greater extent when compared to the binary solid dispersion. Excipients that can be used as a third component includes surfactants, pH modulator, polymer and adsorbents. All these excipients have distinct benefits in improving the efficiency of the final dosage form. However, care must be taken in selecting the suitable excipients for the research. This review highlights the impact of these excipients in improving the formulation complications and the therapeutic potential of the ternary solid dispersion.
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