RECENT APPROACHES INVOLVED IN COLONIC DRUG TARGETING FOR THE TREATMENT OF INFLAMMATORY BOWEL DISEASE: A REVIEW

  • SWAMINATHAN V. PSG college of pharmacy
  • VAIYANA RAJESH C. PSG college of pharmacy

Abstract

The objective of the review is to present about the contemporary approaches involved in colonic drug targeting for the therapy of inflammatory bowel disease (IBD). The adverse reactions and side-effects of the conventional drug delivery systems are largely on account of the systemic absorption of the drugs from the small intestine. Moreover in current drug delivery systems, the drug has to be frequently administered and also in larger doses which greatly reduces the patient compliance. Various approaches which are being investigated here, mainly targets colonic region specifically for improved therapy of IBD, by increasing localization and accessibility of the drug to the target site. Also these approaches results in reduction of dose and minimization of adverse effects combined with the use of conventional drug delivery systems.

Keywords: Anti-inflammatory drugs, colonic drug targeting, Mesalamine, Curcumin, Nucleotide delivery vehicle
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V., S., & RAJESH C., V. (2021). RECENT APPROACHES INVOLVED IN COLONIC DRUG TARGETING FOR THE TREATMENT OF INFLAMMATORY BOWEL DISEASE: A REVIEW. International Journal of Applied Pharmaceutics, 13(4). https://doi.org/10.22159/ijap.2021v13i4.40893
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Review Article(s)