Enhancement of the Solubility of Famotidine Solid Dispersion Using Natural Polymer by Solvent Evaporation Method
The aims of study to enhance solubility and dissolution rate of famotidine using natural polymer. Solubility study of a drug is one of the contributing factor of its oral bioavailability. The formulation of poorly soluble drugs for oral delivery presents a challenge to the formulation technologists. The present study has shown that it is possible to rise the solubility for poorly soluble drugs like famotidine, by preparing solid dispersion using natural water soluble polymer (xyloglucan and hyaluronic acid) as solubilizer through solvent evaporation method. Physical mixture and Solid Dispersion of famotidine with xyloglucan (XG) or hyaluronic acid in ratio of 1:1, 1:2, 1:3 were prepared. Solubility study, Drug content, Dissolution profile and compatibility study were performed for famotidine in Solid dispersions XS1, XS2, XS3, HS4, HS5, HS6 as well as in Physical mixtures at ratio 1:1 for both polymer (XG and hyaluronic acid). It was observed that solid dispersions of each drugs showed increase in dissolution rate in comparison with its pure drug in the ratio of 1:1 (Drug: carrier). It can be concluded that with the careful and proper use of xyloglucan, solubility of drugs poorly soluble can be improved.
The prepared natural solid dispersion showed improvement of drug solubility in all prepared formula. The best result was obtained with formula XS1 (famotidine : xyloglucan 1:1) that showed 8.07 and 5.38 fold increase in solubility compared to solubility of pure drug due to increased wettability and reduced crystallinity of the drug which leads to improving solubility and dissolution.
2. Bakatselou V, Oppenheim RC, Dressman JBJPr. Solubilization and wetting effects of bile salts on the dissolution of steroids. 1991;8(12):1461-1469.
3. Chiou WL, Riegelman SJJops. Pharmaceutical applications of solid dispersion systems. 1971;60(9):1281-1302.
4. Noyes AA, Whitney WRJJotACS. The rate of solution of solid substances in their own solutions. 1897;19(12):930-934.
5. Anamika S, Shikha AJIJoP, Archives B. Solubility enhancement potential of tamarind seed polysaccharide as pharmaceutical excipient. 2012;3(3):456-459.
6. Alkufi H, Kassab Hanan. Formulation and Evaluation of Sustained Release Sumatriptan Mucoadhesive Intranasal in-Situ Gel. 2019;28(2):95-104.
7. Shafique M, Khan MA, Khan WS, Ahmad W, Khan SJJoN. Fabrication, characterization, and in vivo evaluation of famotidine loaded solid lipid nanoparticles for boosting oral bioavailability. 2017;2017.
8. Verma U, Naik J, Mokale V, editors. Preparation and Characterisation of the Inclusion Complex of Famotidine with (2-Hydroxy Propyl)–?-Cyclodextrin & PVP K-30: Effects on Solubility and Bitter Taste Mask. Int Conf Adv Chem Eng Technol; 2014.
9. Uddin R, Ali F, Biswas SKJSJoPS. Water solubility enhancement of atorvastatin by solid dispersion method. 2010;3(2):43-46.
10. USP29-NF24 UPJR, MD. US Pharmacopoeial Convention. 2006.
11. Jouyban A. Handbook of solubility data for pharmaceuticals: Crc Press; 2009.
12. Das A, Nayak AK, Mohanty B, Panda SJIp. Solubility and dissolution enhancement of etoricoxib by solid dispersion technique using sugar carriers. 2011;2011.
13. Shete AS, Yadav AV, Murthy SMJDJoPS. Chitosan and chitosan chlorhydrate based various approaches for enhancement of dissolution rate of carvedilol. 2012;20(1):93.
14. Afifi SJIjoprI. Solid dispersion approach improving dissolution rate of Stiripentol: a novel antiepileptic drug. 2015;14(4):1001.
15. Jaimini M, Rana A, Tanwar YJCdd. Formulation and evaluation of famotidine floating tablets. 2007;4(1):51-55.
16. PITCHESWARA RAO T, SATYANARAYANA V, VIJAYA KUMAR B, SRINIVASA BABU PJTIp. ENHANCEMENT OF SOLUBILITY AND DISSOLUTION RATE OF IRBESARTAN BY SOLID DISPERSION TECHNIQUE. 2010;9(6):73-76.
17. Kalra K, Sharma S, Jain DJIJoP, Sciences L. Enhancement of solubility and dissolution rate of rifapentine by melt granulation technique. 2012;3(3).
18. Moffat AC, Osselton MD, Widdop B, Watts J. Clarke's analysis of drugs and poisons: Pharmaceutical press London; 2011.
19. Mohite M, Shet S, Shaikh S, Aaidya V, Karodi RJIJRAP. Analytical method development of famotidine USP in bulk and single component formulation. 2010;1(2):475-479.
20. Cartwright AC. The British pharmacopoeia, 1864 to 2014: medicines, international standards and the state: Routledge; 2016.
21. Sarada A, Lohithasu D, Chamundeswari V, Midhun Kumar D, Ramya SJGJP. Enhancement of dissolution rate of Ritonavir: a comparative study using various carriers and Techniques. 2015;9(4):326-340.
22. Sharma A, Jain CP, Tanwar YSJJotCCS. Preparation and characterization of solid dispersions of carvedilol with poloxamer 188. 2013;58(1):1553-1557.
23. Farias MD, Albuquerque PB, Soares PA, de Sá DM, Vicente AA, Carneiro-da-Cunha MGJIjobm. Xyloglucan from Hymenaea courbaril var. courbaril seeds as encapsulating agent of L-ascorbic acid. 2018;107:1559-1566.
24. Sharma AJDPL. Preparation and characterization of solid dispersions of Valsartan with Poloxamer 188. 2010;2:54-63.
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