Enhancement of the Solubility of Famotidine Solid Dispersion Using Natural Polymer by Solvent Evaporation Method

  • hussein k.jawad university of thi_qar

Abstract

The aims of study to enhance solubility and dissolution rate  of famotidine using natural polymer. Solubility study of a drug is one of the contributing factor of its oral bioavailability. The formulation of poorly soluble drugs for oral delivery presents a challenge to the formulation technologists. The present study has shown that it is possible to rise the solubility for poorly soluble drugs like famotidine, by preparing solid dispersion using natural water soluble polymer  (xyloglucan and hyaluronic acid) as solubilizer through solvent evaporation method. Physical mixture and Solid Dispersion of famotidine with xyloglucan (XG) or hyaluronic acid in ratio of 1:1, 1:2, 1:3 were prepared. Solubility study, Drug content, Dissolution profile and compatibility study were performed for famotidine in Solid dispersions XS1, XS2, XS3, HS4, HS5, HS6  as well as in Physical mixtures at ratio 1:1 for both polymer (XG and hyaluronic acid). It was observed that solid dispersions of each drugs showed increase in dissolution rate in comparison with its pure drug in the ratio of 1:1 (Drug: carrier). It can be concluded that with the careful and proper use of xyloglucan, solubility of drugs poorly soluble can be improved.


The prepared natural solid dispersion showed improvement of drug solubility in all prepared formula. The best result was obtained with formula XS1 (famotidine : xyloglucan 1:1) that showed 8.07 and 5.38 fold increase in solubility compared to solubility of pure drug due to increased wettability and reduced crystallinity of the drug which leads to improving solubility and dissolution.

Keywords: Famotidine; Glacial acetic acid; Physical mixture; Solid dispersion; Solvent evaporation; Xyloglucan; Hyaluronic acid.

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k.jawad, hussein. (2021). Enhancement of the Solubility of Famotidine Solid Dispersion Using Natural Polymer by Solvent Evaporation Method. International Journal of Applied Pharmaceutics, 13(3). https://doi.org/10.22159/ijap.2021v13i3.40934
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