• LING-YU LU Department of Pharmacy, Taoyuan Psychiatric Center, Taoyuan, Taiwan.
  • CHUN-CHIA TSAI Department of Pharmacy, Taoyuan Psychiatric Center, Taoyuan, Taiwan



Agomelatine, Melatonin, Insomnia, Chi-squared test, Logistic regression


Objective: Agomelatine is a new mechanism of antidepressants, which is approved by Taiwan Food and Drug Administration and available in Taiwan.
Agomelatine behaves both as a potent agonist at melatonin MT1 and MT2 receptors and as a neutral antagonist at 5-HT2C receptors. The structures
of agomelatine are similar to melatonin with not only the effects to maintain depression symptoms but also can help patients who have insomnia.
Methods: This is a retrospective study. In a mental hospital in Taoyuan, we analyzed the prescriptions of the outpatients who were prescribed
agomelatine to realize the effects of agomelatine and whether the prescriptions were prescribed appropriately.
Results: Catastrophic illnesses were found to be associated with significantly used multiple hypnotics (χ2 =22.02, p<0.001). When patients’ age
increased by 1 year, multiple hypnotics used increased by 1.013 times (Exp(B)=1.013, p<0.01). Catastrophic illnesses were found to be associated
with significantly used augmentation with other antidepressants (χ2=54.07, p<0.001).
Conclusions: Doctors should be evaluating the benefits and risks when they prescribe a medicine to patients, and they should be written in medical
record. This study is the hope to provide relevant units as a reference for formulating health policies.


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How to Cite

LU, L.-Y., & TSAI, C.-C. (2021). ANALYSIS OF AGOMELATINE TREATMENT WITH DEPRESSIVE SYMPTOMS. International Journal of Applied Pharmaceutics, 13(1), 63–66.



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