POROUS PLASTIC MATRIX TABLETS OF LEVETIRACETAM FOR ZERO-ORDER CONTROLLED RELEASE: DEVELOPMENT AND FORMULATION OPTIMIZATION

  • RAVI PARIMI University College of Pharmaceutical Sciences, Acharya Nagarjuna University, Nagarjuna Nagar, Guntur 522510, Andhra Pradesh, India
  • RAMA RAO VADAPALLI K. E. PRAVALLIKA
  • K. E. PRAVALLIKA University College of Pharmaceutical Sciences, Acharya Nagarjuna University, Nagarjuna Nagar, Guntur 522510, Andhra Pradesh, India

Abstract

Objective:The prior objective of the current research work was to develop a once daily levetiracetam extended-release tablets having zero-order release kinetics with plastic matrix as the release retarding element. For a high water-soluble drug, the formulation of a dosage form so as to have an extended drug release has always been a difficult task. Methods:In the current work, levetiracetam which is a highly soluble drug was taken as the model drug for which extended-release matrix tablets were developed using varied plastic polymers like Polyvinyl acetate (PVAc), Polyvinyl chloride (PVC), Eudragit RSPO and Eudragit RLPO. PVP was considered as a pore forming agent and PEG 6000 was taken as water regulating agent. The porous plastic matrix tablets were prepared by embedding the drug in solvent-activated polymer dispersion followed bydrying, sieving, mixing with other excipients and finally compressed. Including physical characterization studies and drug release studies, the tablets were subjected to SEM studies before and after the dissolution studies to analyze the effect of the pore former. Results: The tablets were strong enough with good tensile strength and less friability. Drug release study results of all the formulations showed that the time of drug release was controlled for a period of 12 – 24hr. PVAc had shown better control release among all the plastic polymers taken.PVP and PEG 600 showed significant influence on the drug release. Conclusion:Thelevetiracetam porous plastic matrix tablets were developed with zero-order release of drug that was effectively controlled for a period of 24hr.

Keywords: Porous plastic matrix, Pore former, Highlysoluble drugs, Zero-order controlled release, Embedding

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PARIMI, R., VADAPALLI, R. R., & PRAVALLIKA, K. E. (2021). POROUS PLASTIC MATRIX TABLETS OF LEVETIRACETAM FOR ZERO-ORDER CONTROLLED RELEASE: DEVELOPMENT AND FORMULATION OPTIMIZATION. International Journal of Applied Pharmaceutics, 13(4). https://doi.org/10.22159/ijap.2021v13i4.41172
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