SNEDDS AS LIPID-BASED NANOCARRIER SYSTEMS: CONCEPTS AND FORMULATION INSIGHTS

Authors

  • LAKSHMI DEVI GOTTEMUKKULA Gitam School of Pharmacy, GITAM (Deemed to Be University), Rudraram, Hyderabad campus, Telangana, India
  • SUNITHA SAMPATHI Gitam School of Pharmacy, GITAM (Deemed to Be University), Rudraram, Hyderabad campus, Telangana, India

DOI:

https://doi.org/10.22159/ijap.2022v14i2.42930

Keywords:

In-vitro assessment of self-emulsification, LBDDS, low bioavailability, low solubility, SEDDS, SMEDDS, and SNEDDS

Abstract

Approximately 40 % of newly discovered chemical entities have low solubility and possess low bioavailability after oral administration. Lipid-based drug delivery systems (LBDDS) have recently become very popular because of their remarkable ability to deliver drugs with poor absorption using lipids as carriers. Self-emulsifying drug delivery (SEDDS) systems are one type of LBDDS employed for the incorporation of hydrophobic drugs. SEDDS are classified into self-micro emulsifying drug delivery systems (SMEDDS) and self-nano emulsifying drug delivery systems (SNEDDS) based on the droplet size of the dispersed phase. The present review focus on the mechanism of drug absorption from lipid-based nanocarriers systems, in-vitro assessment of self-emulsification, insights of SNEDDS, factors affecting the formulation of SNEDDS, and its applications.

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Published

23-12-2021

How to Cite

GOTTEMUKKULA, L. D., & SAMPATHI, S. (2021). SNEDDS AS LIPID-BASED NANOCARRIER SYSTEMS: CONCEPTS AND FORMULATION INSIGHTS. International Journal of Applied Pharmaceutics, 14(2). https://doi.org/10.22159/ijap.2022v14i2.42930

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Review Article(s)