THE ANTI-INFLAMMATORY TABLET FORMULATION OF COLEUS (PLECTRANTHUS SCUTELLARIODES) LEAVES EXTRACT USING KOLLICOAT®PROTECT COATING

Authors

  • RESMI MUSTARICHIE Department of Pharmaceutical Analysis and Medicinal Chemistry, Faculty of Pharmacy, Universitas Padjadjaran, Jl Raya Bandung Sumedang km 21 Sumedang, Indonesia 45363
  • DANNI RAMDHANI Department of Pharmaceutical Analysis and Medicinal Chemistry, Faculty of Pharmacy, Universitas Padjadjaran, Jl Raya Bandung Sumedang km 21 Sumedang, Indonesia 45363
  • NYI MEKAR SAPTARINI Department of Pharmaceutical Analysis and Medicinal Chemistry, Faculty of Pharmacy, Universitas Padjadjaran, Jl Raya Bandung Sumedang km 21 Sumedang, Indonesia 45363

DOI:

https://doi.org/10.22159/ijap.2022.v14s4.PP40

Keywords:

Coleus leaves, Film-Coated Tablet, Flavonoids, Kollicoat® Protect

Abstract

Objective: The purpose of this study was to find the concentration of weight gain on the use of Kollicoat®Protect to produce coleus leaf extract film-coated tablets with good physical properties.

Methods: Coleus extract was obtained by maceration using 70% ethanol. Tablet cores were prepared using the wet granulation method, then evaluated (uniformity of weight, size, hardness, friability, and disintegration time). Coated tablets were made in four variations of polymer weight gain, i.e. 5, 6, 7, and 8%. To determine the effect of the weight gain concentration of Kollicoat®Protect an evaluation of the coated tablets was carried out, i.e. the uniformity of weight, size, hardness, disintegration time, and physical appearance of the film-coated tablets.

Results: The four variations (Film Coated Tablet, FCT 5, 6, 7, and 8%) in weight gain of film-coated tablets showed the physical appearance results per the applicable requirements. However, the physical observation test at room temperature showed the instability of the film-coated tablet. The qualitative analysis of thin-layer chromatography showed that the productive substances in the extracts, tablet cores, and film-coated tablets were still contained even though they had undergone several formulation stages.

Conclusion: Film-coated tablets met the standards of the Indonesian Pharmacopoeia and the United States Pharmacopeia. After two weeks, there was slight instability in film-coated tablets at room temperature storage. The extract, tablet core, and film-coated tablet contain flavonoids.

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References

Dalimartha S. Atlas tumbuhan obat Indonesia. Jilid Ke-2. Jakarta: Trubus Agriwidya; 2003. p. 65-70.

Sudjarwo SA. Efek hambatan dari quercetin terhadap siklooksigenase dan produksi prostaglandin pada udem telapak kaki tikus yang disebabkan oleh karagenan [thesis]. Surabaya: Universitas Airlangga; 2006.

Syafrudin PS. Analisis kandungan flavonoid total ekstrak daun coleus plectranthus scutellarioides (L.) R. Br.) dihitung sebagai kuersetin dengan metode kromatografi cair kinerja tinggi. Thesis. Jatinangor: Fakultas Farmasi. Universitas Padjadjaran; 2008.

Allen LV, Popovich NG, Ansel HC, Ansel HC. Ansel’s pharmaceutical dosage form and drug delivery systems. Philadelphia: Lippincott Williams & Wilkins; 2005. p. 244-99.

BASF. Technical information of Kollicoat®protect. Germany: BASF; 2004.

Depkes RI. Farmakope Indonesia. Edisi VI. Jakarta: Departemen Kesehatan Republik Indonesia; 2020. p. 1087.

Mustarichie R, Priambodo D. Tablet formulation from Meniran (Phyllanthus niruri L.) extract with direct compression method. Int J App Pharm. 2018;10(4):98-102. doi: 10.22159/ijap.2018v10i4.26795.

Levita J, Sumiwi SA, Pratiwi TI, Ilham E, Sidiq SP, Moektiwardoyo M. Pharmacological activities of Plectranthus scutellarioides (L.) R. Br. leaves extract on cyclooxygenase and xanthine oxidase enzymes. J Med Plants Res. 2016;10(20):261-9.

Fakhriati SG, Musfiroh I, Moektiwardoyo M, Akmarina Citra AAC. Inhibition of nitric oxide production in lipopolysaccharide-induced macrophages cell by plectranthus scutellarioides (L.) R. br leaves. Res J Chem Environ. 2018;22Special Issue I:38-42.

Su WC. Philippine’s medicinal plant mayana plectranthus scutellarioides (L.); March 2021. Available from: http://www.stuartxchange.org/Badiara.HTML. [Last accessed on 22 Oct 2022]

Saptarini NM, Hadisoebroto G. Formulation and evaluation of lotion and cream of nanosized chitosan-mangosteen (Garcinia mangostana L.) pericarp extract. Rasayan J Chem. 2020;13(2):789-95. doi: 10.31788/RJC.2020.1325533.

Aulton ME. Pharmaceutics: the science of dosage form design. New York: Longman Group. Churchill Livingstone; 2002. p. 612-4.

Lachman L, Lieberman HA, Kanig JL. Teori dan praktek farmasi Industri II [The theory and practice of industrial pharmacy by Lachman and Lieberman]. Uipress, Jakarta Suyatmia Siti, translator; 1994. p. 645, 680-90, 701-3.

Shah RB, Tawakkul MA, Khan MA. Comparative evaluation of flow for pharmaceutical powders and granules. AAPS PharmSciTech. 2008;9(1):250-8. doi: 10.1208/s12249-008-9046-8, PMID 18446489.

Ferreira ISB, Peruchi RS, Fernandes NJ, Rotella Junior P. Measurement system analysis in angle of repose of fertilizers with distinct granulometries. Measurement. 2021;170:108681. doi: 10.1016/j.measurement.2020.108681.

Madrid MA, Fuentes JM, Ayuga F, Gallego E. Determination of the angle of repose and coefficient of rolling friction for wood pellets. Agronomy. 2022;12(2):424. doi: 10.3390/ agronomy12020424.

Schüssele A, Bauer Brandl A. Note on the measurement of flowability according to the European pharmacopoeia. Int J Pharm. 2003;257(1-2):301-4. doi: 10.1016/s0378-5173(03)00142-x, PMID 12711185.

Crouter A, Briens L. The effect of moisture on the flowability of pharmaceutical excipients. AAPS PharmSciTech. 2014;15(1):65-74. doi: 10.1208/s12249-013-0036-0, PMID 24092523.

Sushma D. Formulation and evaluation of press-coated tablets for pulsatile drug delivery. J Biomed Syst Emerg Technol. 2021;8(5):1-3.

Elghnimi TY, Ammar AA, Saadawi S, Algeryani AM. Pharmaceutical evaluation of some commercial brands of metronidazole 500 mg tablets marketed in tripoli libya. Int J Sci Study. 2022;10(12):97-104.

Wang J, Hemenway J, Chen W, Desai D, Early W, Paruchuri S. An evaluation of process parameters to improve coating efficiency of an active tablet film-coating process. Int J Pharm. 2012;427(2):163-9. doi: 10.1016/j.ijpharm.2012.01.033, PMID 22301427.

Zaid AN, Al-Ramahi RJ, Ghoush AA, Qaddumi AQ, Zaaror YA. Weight and content uniformity of lorazepam half-tablets: A study of correlation of a low drug content product. Saudi Pharm J. 2013;21(1):71-5. doi: 10.1016/j.jsps.2011.12.009, PMID 23960821.

Yalkowsky SH, Bolton S. Particle size and content uniformity. Pharm Res. 1990;7(9):962-6. doi: 10.1023/a:1015958209643, PMID 2235898.

Cuitino A. Hardness testing of pharmaceutical tablets; 2022. Available from: http://www.acumenbiopharma.com/wp-content/uploads/2019/01/Hardness-of-Pharmaceutical-Tablets.pdf.

Nayak BK, Elchidana P, Dixit M, Sahu PK, Anusandhan SO, Bhub G. QbD approach: tablet compression process optimization using design of experiments. Int J Pharm Sci Rev Res. 2016;38(2):45-53.

USA Pharmacopeial Convention. Twin brook parkway Rockville MD, United States pharmacopeial convention. Inc. United States Pharmacopeia; 2005. p. 2745.

Gordon M. Process considerations in reducing tablet friability and their effect on in vitro dissolution. Drug Dev Ind Pharm. 2008;20(1):11-29.

Kulkarni I, Chimangude P, Wagha V, Kolatkar A. Formulation and evaluation of Triphalaguggulkalpa tablets for optimum disintegration time. Int J Pharm Sci Rev Res. 2015;34(1):270-5.

Markl D, Zeitler JA. A review of disintegration mechanisms and measurement techniques. Pharm Res. 2017;34(5):890-917. doi: 10.1007/s11095-017-2129-z, PMID 28251425.

Fussnegger B, Tawde V, Chivate A, Kolter K, Ali S. Kollicoat® IR: minimizing the risks for oxidative degradation of drugs. J Anal Pharm Res. 2016;2(3):00020.

Luke S, Ervina M, Hadisoewignyo L. Optimization of coating formula of white pomegranate peel extract (Punica granatum L.) film coated tablet using Kollicoat protect, Indo. J Pharm Res. 2021;1(1):1-9.

European pharmacopoeia. Ph Eur. 10th ed.

Wu XL, Wang MJ, Kuang Y, Zhang WJ, Ao QX. A clinical study of Naoxinqing tablet’s effects on blood fat and viscosity A clinical research of Naoxinqing tablet’s effects on blood fat and viscosity. Zhong Yao Cai. 2008;31(1):171-4. PMID 18589766.

Tadikonda RR, Sreemantula S. In vivo evaluation of theophylline sustained release matrix tablets containing low viscosity guar gum. IJPSRR. 2021;71(2):38-43. doi: 10.47583/ijpsrr.2021.v71i02.006.

Fathi Azarbayjani AF, Jouyban A, Chan SY. Impact of surface tension in pharmaceutical sciences. J Pharm Pharm Sci. 2009;12(2):218-28. doi: 10.18433/j32p40, PMID 19732499.

Bzdek BR, Reid JP, Malila J, Prisle NL. The surface tension of surfactant-containing, finite-volume droplets. Proc Natl Acad Sci USA. 2020;117(15):8335-43. doi: 10.1073/pnas. 1915660117, PMID 32238561.

Published

26-11-2022

How to Cite

MUSTARICHIE, R., RAMDHANI, D., & SAPTARINI, N. M. (2022). THE ANTI-INFLAMMATORY TABLET FORMULATION OF COLEUS (PLECTRANTHUS SCUTELLARIODES) LEAVES EXTRACT USING KOLLICOAT®PROTECT COATING. International Journal of Applied Pharmaceutics, 14(4), 159–162. https://doi.org/10.22159/ijap.2022.v14s4.PP40

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