@article{Azizah_Sagita_Iskandarsyah_2017, title={IN VITRO PENETRATION TESTS OF TRANSETHOSOME GEL PREPARATIONS CONTAINING CAPSAICIN}, volume={9}, url={https://journals.innovareacademics.in/index.php/ijap/article/view/23309}, DOI={10.22159/ijap.2017.v9s1.68_75}, abstractNote={<p>Objective: Capsaicin is an active compound found in chili pepper and has been shown to have analgesic, antioxidant, anticancer, and anti-obesity<br />properties. To improve its penetration into the skin, capsaicin was prepared in a transethosome vesicle. Importantly, transethosomes are vesicles that<br />consist of phosphatidylcholine, surfactant, and ethanol. In this study, capsaicin was prepared in a transethosome vesicle using two different methods:<br />Direct transethosome formation and thin layer hydration. The aims of this study were to determine the effects of various methods of transethosome<br />formation on capsaicin characteristics and to evaluate the penetration capabilities of transethosome capsaicin gel.<br />Methods: Ultimately, transethosome formation via the thin layer method yielded more favorable characteristics; these formations had particle sizes<br />of 174.9±2.02 nm and an entrapment efficiency of 84.85±1.15%. The transethosome suspension was then developed into a gel formulation using 1%<br />carbomer. An in vitro penetration test was performed using a Franz diffusion cell of mice abdomen skin, and the performance of the transethosome<br />capsaicin gel was compared to that of the standard capsaicin gel.<br />Results: Penetration rate of capsaicin from either the transethosome gel preparation and the standard gel substance was 1549.68±49.6 and<br />846.05±10.1 μg/cm2, respectively.<br />Conclusions: According to these results, it can be concluded that gel preparations containing transethosome increase capsaicin penetration into the<br />skin.</p>}, journal={International Journal of Applied Pharmaceutics}, author={Azizah, Nuraini and Sagita, Erny and Iskandarsyah, Iskandarsyah}, year={2017}, month={Oct.}, pages={116–119} }