@article{Wulansari_Jufri_Budianti_2017, title={STUDIES ON THE FORMULATION, PHYSICAL STABILITY, AND IN VITRO ANTIBACTERIAL ACTIVITY OF TEA TREE OIL (MELALEUCA ALTERNIFOLIA) NANOEMULSION GEL}, volume={9}, url={https://journals.innovareacademics.in/index.php/ijap/article/view/23327}, DOI={10.22159/ijap.2017.v9s1.73_80}, abstractNote={<p>Objective: This study aimed to formulate tea tree oil into a nanoemulsion gel dosage form and evaluate its physical stability and antibacterial activity.<br />Methods: Nanoemulsion gels were formulated with various concentrations of tea tree oil, namely, 5%, 7%, and 9%, using Tween-80 as a surfactant<br />and propylene glycol as a cosurfactant. The tea tree oil nanoemulsion gels showed a stable physical appearance over 8 weeks of storage at low<br />temperature (4±2°C) and room temperature (25±2°C), cycling test, and centrifugation test.<br />Results: The best formula was nanoemulsion gel formulation 1 (F1), which contained 5% tea tree oil, due to its good stability, smaller globule size,<br />and greater viscosity. The results for antibacterial activity, determined by in vitro study, showed that the tea tree oil nanoemulsion gels exhibited<br />antibacterial activity against Propionibacterium acnes through the formation of an inhibition zone.<br />Conclusion: Higher concentrations of tea tree oil in nanoemulsion gels (5%, 7%, and 9%) showed greater mean inhibition zones (28.33±0.88 mm,<br />30.33±0.33 mm, and 31.67±0.33 mm, respectively).</p>}, journal={International Journal of Applied Pharmaceutics}, author={Wulansari, Aprilla and Jufri, Mahdi and Budianti, Angky}, year={2017}, month={Oct.}, pages={135–139} }