@article{Wagh_Mutha_2018, title={DEVELOPMENT AND OPTIMIZATION OF RIZATRIPTAN BENZOATE ETHOSOMES}, volume={10}, url={https://journals.innovareacademics.in/index.php/ijap/article/view/24354}, DOI={10.22159/ijap.2018v10i2.24354}, abstractNote={<p><strong>Objective: </strong>The objective of this study was to assess the development of ethosomal drug delivery system for site-specific topical delivery of rizatriptan benzoate (RBZ) for sustained action.</p><p><strong>Methods: </strong>In the present study ethosomes were prepared using the cold method. The formulation was optimized using 3<sup>3</sup> full factorial designs. The lipid concentration (X<sub>1</sub>), ethanol concentration (X<sub>2</sub>) and stirring speed (X<sub>3</sub>) were selected as independent factors and the vesicle size (Y<sub>1</sub>) and % entrapment efficiency (Y<sub>2</sub>) were selected as dependent variables.</p><p><strong>Results: </strong>The equation of multiple regression revealed that there was no significant interaction among factors. The lipid concentration had a positive effect on vesicle size while ethanol concentration and stirring speed had a negative effect. For entrapment efficiency, all factors showed a positive effect while lipid concentrative found to be the main influencing factor. The formulation F4E459 (4% SPC, 45% v/v ethanol 900 RPM), which was characterized by optimum vesicle size (5.5 µm) and high entrapment efficiency (93.32%), was considered to be an optimal formulation. The scanning electron microscopy (SEM) results showed that RBZ ethosome have a smooth surface. The polydispersity index (PI) and zeta potential of the optimized formulation were found to be 0.493±0.021and–21.3 mV respectively. <em>In vitro</em> permeation through rat abdominal skin from the ethosomal gel followed Higuchi diffusion model over a period of 8 h.</p><p class="AbstractCxSpFirst"><strong>Conclusion: </strong>The results obtained in this research work clearly indicated a promising potential of ethosomal carrier system of RBZ for migraine treatment with a topical approach for sustained action.</p>}, number={2}, journal={International Journal of Applied Pharmaceutics}, author={Wagh, Milind P. and Mutha, Swati S.}, year={2018}, month={Mar.}, pages={83–90} }