@article{Surini_Ariani_Putri_Hayun_Anwar_2018, title={COPROCESSED EXCIPIENTS OF CROSSLINKED AMYLOSE AND XANTHAN GUM FOR USE IN CONTROLLED RELEASE DOSAGE FORMS}, volume={10}, url={https://journals.innovareacademics.in/index.php/ijap/article/view/31423}, DOI={10.22159/ijap.2018.v10s1.13}, abstractNote={<p><strong>Objective</strong>: This study was aimed to obtain a new excipient that can be used as a polymer matrix for the formulation of controlled release dosage forms.<br /><strong>Methods</strong>: This study used coprocessing and crosslinking methods on amylose and xanthan gum (XG) to obtain a new excipient that can be used<br />for controlled release matrix of pharmaceutical dosage forms. The coprocessing step was conducted by drum drying, and the crosslinking step was<br />prepared using 6 and 12% sodium trimetaphosphate (STMP). The produced novel excipients were characterized in terms of infrared (IR) spectrum,<br />substitution degree, moisture content, swelling index, and gel strength.<br /><strong>Results</strong>: Our results showed that amylose–XG excipients crosslinked using 6% STMP have greater gel strength and better swelling indexes than<br />excipients crosslinked using 12% STMP. All coprocessed excipients exhibited no differences in their IR spectra, whereas the crosslinked excipients<br />did, indicating a structural change due to the addition of phosphate groups. Crosslinking amylose–xanthan-coprocessed excipients using 6% STMP<br />produced degrees of substitution (DSs) of 7–8 phosphates per 100 monomeric subunits. The excipients had a moisture content of 8.21–12.85%, and<br />the pH of a 1% solution of excipients was 6.21–6.43. In addition, the swelling index and gel strength of the excipient where both amylose and XG were<br />crosslinked together Were more than 1 where only amylose was crosslinked.<br /><strong>Conclusion</strong>: The crosslinking amylose–xanthan-coprocessed excipient using 6% STMP is more suitable for use in controlled release dosage forms,<br />particularly when the polymer ratio is 1:1.</p>}, number={1}, journal={International Journal of Applied Pharmaceutics}, author={Surini, Silvia and Ariani, Lusiana and Putri, Kurnia Ss and Hayun, Hayun and Anwar, Effionora}, year={2018}, month={Dec.}, pages={59–65} }