@article{Anwar_Ramadon_Ardi_2018, title={NOVEL TRANSETHOSOME CONTAINING GREEN TEA (CAMELLIA SINENSIS L. KUNTZE) LEAF EXTRACT FOR ENHANCED SKIN DELIVERY OF EPIGALLOCATECHIN GALLATE: FORMULATION AND IN VITRO PENETRATION TEST}, volume={10}, url={https://journals.innovareacademics.in/index.php/ijap/article/view/31526}, DOI={10.22159/ijap.2018.v10s1.66}, abstractNote={<p><strong>Objective</strong>: This study aimed to formulate a transethosome cream (TEC) to increase skin penetration of epigallocatechin gallate (EGCG) in green tea<br />leaf extract and evaluate their physicochemical characteristics and skin penetration capacity.<br /><strong>Methods</strong>: Transethosomes were prepared through thin-layer hydration method in three formulations (F1−F3) with different Span 80 and ethanol concentrations.<br />Transethosome morphology was characterized using transmission electron microscopy, particle size, polydispersity (PDI), and zeta potential using a particle<br />size analyzer and entrapment efficiency (EE). Penetration was tested using an in vitro Franz diffusion cell with female Sprague-Dawley rat skin as the<br />membrane.<br /><strong>Results</strong>: Transethosome F2 containing green tea extract equivalent to 3% EGCG, 4% Lipoid P30, 0.75% Span 80, and 30% ethanol had the best<br />characteristic including spherical shape, smallest particle size (35.35 nm), 0.319 PDI, zeta potential of −29.97±3.05 mV, and highest EE of<br />45.26%±8.15%. TEC permitted greater flux than non-TEC (first phase: 60.56±4.52 vs. 25.69±0.83 μg•cm−2•h−1 and second phase: 23.13±1.38 vs.<br />7.36±1.59 μg•cm−2•h−1).<br /><strong>Conclusion</strong>: Transethosome can increase the skin penetration of green tea leaf extract.</p>}, number={1}, journal={International Journal of Applied Pharmaceutics}, author={Anwar, Effionora and Ramadon, Delly and Ardi, Ghina Desviyanti}, year={2018}, month={Dec.}, pages={299–302} }