@article{Wei_Ascobat_Rohsiswatmo_Instiaty_2018, title={QUALITATIVE REVIEW OF ANTIBIOTIC USE FOR NEONATAL SEPSIS}, volume={10}, url={https://journals.innovareacademics.in/index.php/ijap/article/view/31544}, DOI={10.22159/ijap.2018.v10s1.80}, abstractNote={<p><strong>Objective</strong>: The aim of this study is to evaluate the antibiotic use in neonates with sepsis.<br /><strong>Methods</strong>: An observational retrospective study was conducted using medical records of neonates diagnosed with early-/late-onset sepsis who were<br />prescribed antibiotics and who were treated in the neonatal intensive care unit (NICU) at the Dr. Cipto Mangunkusumo Hospital between January 1 and<br />December 31, 2015. Patient records were screened for antibiotic use; qualitative analyses were performed using the Gyssens algorithm. Concordance<br />of empirical antibiotic prescriptions with subsequent blood culture and sensitivity tests was evaluated.<br /><strong>Results</strong>: A total of 176 sepsis cases included 80 and 96 neonates with normal and low birth weights (LBWs), respectively. Ampicillinsulbactam+<br />gentamycin, which is indicated in local guidelines as the first-line antibiotic combination for neonatal sepsis, was most frequently<br />prescribed. In the normal birth weight group, appropriate antibiotic use (Gyssens Category I) was found in 89.7% of cases, whereas Gyssens Category V<br />(no indication) was found in 4.54% of cases. In the LBW group, 88.1% and 6.2% of cases were included in Gyssens Categories I and V, respectively.<br />Only 17.5% and 13.5% cultured blood specimens from normal and LBW groups, respectively, yielded positive results; the most commonly identified<br />bacteria were Acinetobacter baumannii and Klebsiella pneumonia. All isolates were resistant to ampicillin-sulbactam; only 7.4% were sensitive to<br />gentamicin.<br /><strong>Conclusion</strong>: Antibiotic use for neonatal sepsis in NICU in this study can be considered appropriate, suggesting proper implementation of antimicrobial<br />guidelines. However, high rates of resistance to the first-line antibiotics for neonatal sepsis are concerning.</p>}, number={1}, journal={International Journal of Applied Pharmaceutics}, author={Wei, Tjio Ie and Ascobat, Purwantyastuti and Rohsiswatmo, Rinawati and Instiaty, Insti}, year={2018}, month={Dec.}, pages={364–366} }