@article{BONG_SOEKANTO_IDRUS_2019, title={EFFECTS OF CENTELLA ASIATICA (L.) LEAF EXTRACT ON BONE CALCIUM AND PHOSPHATE LEVELS OF OVARIECTOMIZED RATS}, volume={11}, url={https://journals.innovareacademics.in/index.php/ijap/article/view/33364}, DOI={10.22159/ijap.2019.v11s1.AR169}, abstractNote={<p><strong>Objective</strong>: This study aimed to evaluate the efficacy of Centella asiatica leaf extract in maintaining calcium and phosphate levels in the bone for<br>preventing osteoporosis in postmenopausal women.<br><strong>Methods</strong>: The obtained C. asiatica leaf extract was administered to ovariectomized rats at the doses of 60, 120, and 180 mg/kg body weight (BW)<br>for 30 days. Subsequently, the rats were euthanized by ether overdose, and bone calcium and phosphate levels were determined by the wet ashing<br>technique and spectrophotometry.<br><strong>Results</strong>: The results showed no significant differences in the bone calcium and phosphate levels among rats administered with different doses of<br>C. asiatica leaf extract.<br><strong>Conclusion</strong>: Our results indicate that C. asiatica leaf extract cannot be used as a source of phytoestrogens to maintain calcium and phosphate levels<br>in the bones.</p>}, number={1}, journal={International Journal of Applied Pharmaceutics}, author={BONG, YULITA and SOEKANTO, SRI ANGKY and IDRUS, ERIK}, year={2019}, month={Apr.}, pages={67–70} }