@article{TRISNANINGRUM_ASTUTY_2019, title={EFFECTIVENESS OF PROPOLIS WITH ARTEMISININ COMBINATION THERAPY IN TREATING MICE INFECTED WITH PLASMODIUM BERGHEI}, volume={11}, url={https://journals.innovareacademics.in/index.php/ijap/article/view/33455}, DOI={10.22159/ijap.2019.v11s1.012}, abstractNote={<p><strong>Objective</strong>: This study aimed to ascertain the effectiveness of combination treatment with propolis and artemisinin-based combination therapy (ACT)<br>in avoiding further resistance to ACT.<br><strong>Methods</strong>: A total of 35 mice were injected with Plasmodium berghei and divided into six equal groups: No treatment (negative control), ACT alone<br>(positive control), 75-mg propolis/kg body weight (BW), 150-mg propolis/kg BW, ACT with 75-mg propolis/kg BW, and ACT with 150-mg propolis/<br>kg BW. After 7 days of therapy, parasite density was calculated using a thin blood smear.<br><strong>Results</strong>: Parasite density significantly declined after combination treatment with ACT and 150-mg propolis/kg BW.<br><strong>Conclusion</strong>: Therapy with propolis alone showed no inhibitory effect on parasites, although its 150-mg/kg-BW dose was effective as an ACT adjuvant<br>malaria therapy in mice.</p>}, number={1}, journal={International Journal of Applied Pharmaceutics}, author={TRISNANINGRUM, NURINDAH SALOKA and ASTUTY, HENDRI}, year={2019}, month={Apr.}, pages={262–264} }