@article{PURNAMASARI_SAPUTRA_2020, title={EVALUATION OF ORALLY DISINTEGRATING TABLET OF IBUPROFEN-β-CYCLODEXTRIN INCLUSION COMPLEX}, volume={12}, url={https://journals.innovareacademics.in/index.php/ijap/article/view/34848}, DOI={10.22159/ijap.2020v12i2.34848}, abstractNote={<p><strong>Objective: </strong>This study aims to determine the effect of the inclusion complex formation of ibuprofen (IB) with β-cyclodextrin (β-CD) in improving water solubility and taste masking as well as to study the effect of the combined use of super disintegrants in IB-β-CD ODT (Orally disintegrating tablet).</p> <p><strong>Methods: </strong>IB-β-CD inclusion complex was prepared by spray drying technique with a 1:1 molar ratio. ODTs were prepared by the direct compression method using various ratios of Ac-Di-Sol® and Kollidon® CL as super disintegrant. The inclusion complex was characterized using spectroscopy FT-IR (Fourier-transform infrared) and DSC (Differential Scanning Calorimetry). The physical properties and dissolution rate of ODTs were evaluated. Dissolved drug concentration at 60 min (Q<sub>60</sub>) and Dissolution Efficiency (DE<sub>60</sub>) was calculated using the dissolution test result.</p> <p><strong>Results: </strong>The unpleasant taste of IB had been successfully masked by IB-β-CD. Formula 1 was observed having 14.5 sec of disintegration, fastest compared to the other formulas. Moreover DE<sub>60 </sub>value of formula I was higher than the other formulas (113.45).</p> <p><strong>Conclusion: </strong>IB-β-CD Inclusion complex prepared by spray drying method (1: 1) increased the water solubility and masked the unpleasant taste compared to IB moreover combination of Ac-Di-Sol® and Kollidon® CL increased ODT dissolution rate.</p>}, number={2}, journal={International Journal of Applied Pharmaceutics}, author={PURNAMASARI, NUR AINI DEWI and SAPUTRA, PRATAMA ANGGI}, year={2020}, month={Mar.}, pages={60–64} }