@article{PATMAYUNI_SULAIMAN_ZULKARNAIN_2019, title={OPTIMIZATION OF PCL-PEG-PCL TRIBLOCK COPOLYMER MICELLES AS HYDROPHOBIC DRUG CARRIER WITH A 22 FULL FACTORIAL DESIGN}, volume={11}, url={https://innovareacademics.in/journals/index.php/ijap/article/view/35036}, DOI={10.22159/ijap.2019v11i6.35036}, abstractNote={<p><strong>Objective: </strong>This study aims to optimize PCL-PEG-PCL (PCEC) triblock copolymer micelles as a hydrophobic drug carrier, simvastatin (SV).</p> <p><strong>Method</strong><strong>s</strong><strong>:</strong> PCEC triblock copolymer was prepared by the ring-opening polymerization method (ROP) with different ɛCL/PEG ratio (2 and 5). SV was incorporated into the PCEC triblock copolymer micelles with a concentration of 2.5 and 10 % w/w by the solvent evaporation method (film formation). The influence of the ɛCL/PEG ratio and concentration of SV effect on the responses particle size (PS), polydispersity index (PI) and entrapment efficiency (EE) was assessed using 2<sup>2</sup> full factorial design method. The test results were analyzed using Design-Expert software to obtain the optimum formula.</p> <p><strong>Result: </strong>The selection of the optimum formula is based on the desirability value, the formula with the largest desirability value is chosen as the optimum formula. The results showed the optimum formula chosen had a desirability value of 0.860 consisting of a ɛCL/PEG ratio of 5 and SV concentration of 10 % w/w, with the PS<em>, </em>PI dan EE value was 322.1±3.51 nm, 0.471±0.09 and 87.08±1.17 %, respectively.</p> <p><strong>Conclusion: </strong>The 2<sup>2</sup> full factorial design has been proven to be used as an optimization method to determine the optimum formula of SV-loaded PCEC triblock copolymer micelles with a good result of the PS, PI and EE responses.</p>}, number={6}, journal={International Journal of Applied Pharmaceutics}, author={PATMAYUNI, DEWI and SULAIMAN, T. N. SAIFULLAH and ZULKARNAIN, ABDUL KARIM}, year={2019}, month={Nov.}, pages={42–47} }