@article{FIRMANSYAH_NUGRAHANI_WIRASUTISNA_IBRAHIM_2020, title={BORON-SILICA BASED MESOPOROUS FOR CURCUMINOID ISOLATION FROM TURMERIC EXTRACT}, volume={12}, url={https://journals.innovareacademics.in/index.php/ijap/article/view/37041}, DOI={10.22159/ijap.2020v12i5.37041}, abstractNote={<p><strong>Objective: </strong>The purpose of this study was to develop the isolation method for curcuminoid from turmeric extract using boron-silica based mesoporous as an adsorbent.</p> <p><strong>Methods: </strong>The formation of mesoporous materials were conducted using the sol-gel technique. The characterization of mesoporous materials was analyzed using a scanning electron microscope (SEM), transmission electron microscope (TEM), and Fourier transforms infrared spectrometry (FTIR). The extraction of turmeric was done by solvent extraction using ethanol 96 %. The isolation of curcuminoid was achieved by the adsorption method using mesoporous materials, both for silica-based mesoporous (MCM) and boron-silica based mesoporous (BMCM). The elution of curcuminoid-loaded mesoporous was conducted using various solvents. The concentration of total curcuminoid and its compounds was measured by visible spectrometry and high-performance liquid chromatography (HPLC).</p> <p><strong>Results: </strong>Morphology of MCM and BMCM shows the homogenous regular spherical shape, but having a different size. MCM has a smaller diameter particle size (500-600 nm) compared to BMCM (700-900 nm). On the other hand, BMCM has a smaller pore size (1-5 nm) compared to MCM (5-20 nm). The FTIR spectra of BMCM shows the additional vibration at 1400-1600 cm for B-O-H bond. Visible spectrometry measurement shows that the highest concentration of curcuminoid eluted from BMCM is 65.411±0.056 ppm by using ethyl acetate as a solvent, while the concentration of curcuminoid eluted from MCM is 11.503±0.054 ppm by using the same solvent. The results of curcuminoid adsorption and elution, indicating that ethyl acetate is the best solvent to elute curcuminoid due to its 98.83 % purity using HPLC analysis.</p> <p><strong>Conclusion: </strong>It was concluded that boron-silica based mesoporous showed stronger curcuminoid adsorption than silica-based mesoporous therefore found to be a potential adsorbent for curcuminoid isolation from turmeric extract.</p>}, number={5}, journal={International Journal of Applied Pharmaceutics}, author={FIRMANSYAH, ADANG and NUGRAHANI, ILMA and WIRASUTISNA, KOMAR RUSLAN and IBRAHIM, SLAMET}, year={2020}, month={Sep.}, pages={302–306} }